2023
Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells.
Schupp J, Manning E, Chioccioli M, Kamp J, Christian L, Ryu C, Herzog E, Kühnel M, Prasse A, Kaminski N, Jonigk D, Homer R, Neubert L, Ius F, stringJustet A, Hariri L, Seeliger B, Welte T, Knipe R, Gottlieb J. Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 819-822. PMID: 37552025, PMCID: PMC10563189, DOI: 10.1164/rccm.202303-0544le.Peer-Reviewed Original Research
2013
Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection
Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R. Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection. Science 2013, 340: 1230-1234. PMID: 23618765, PMCID: PMC3933032, DOI: 10.1126/science.1233632.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 1CoinfectionDisease Models, AnimalHost-Pathogen InteractionsInterleukin-1betaLegionella pneumophilaLegionnaires' DiseaseLungMiceMice, Inbred C57BLOrthomyxoviridaeOrthomyxoviridae InfectionsPneumonia, BacterialToll-Like Receptor 2Toll-Like Receptor 3Toll-Like Receptor 4Tumor Necrosis Factor-alphaConceptsHost defenseInfluenza virusImmune resistance mechanismsSecondary bacterial pneumoniaInfluenza virus infectionViral-bacterial coinfectionsBacterial coinfectionBacterial pneumoniaVirus infectionMouse modelTissue protectionImmune systemTissue damagePathogen burdenDisease severityBacterial infectionsImpaired abilityInfectionCoinfectionResistance mechanismsVirusLegionella pneumophilaMorbidityPneumoniaFailure
2012
Identification Of An Inflammatory Variant Of Usual Interstitial Pneumonia ("Blue"-Interstitial Pneumonia): Implications For The Prognosis And Treatment Of Idiopathic Interstitial Pneumonia
Meltzer E, Sporn T, Pavlisko E, Homer R, Barry W, Morrison L, Tighe R, Seaman D, Washington L, D'Amico T, Ashley A, Moser B, Roggli V, McAdams H, Leslie K, Noble P. Identification Of An Inflammatory Variant Of Usual Interstitial Pneumonia ("Blue"-Interstitial Pneumonia): Implications For The Prognosis And Treatment Of Idiopathic Interstitial Pneumonia. 2012, a6847-a6847. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6847.Peer-Reviewed Original Research
2008
Cutting Edge: Engagement of NKG2A on CD8+ Effector T Cells Limits Immunopathology in Influenza Pneumonia
Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI. Cutting Edge: Engagement of NKG2A on CD8+ Effector T Cells Limits Immunopathology in Influenza Pneumonia. The Journal Of Immunology 2008, 180: 25-29. PMID: 18096998, DOI: 10.4049/jimmunol.180.1.25.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensCD8-Positive T-LymphocytesHistocompatibility Antigens Class IInfluenza A virusMiceMice, Inbred BALB CMice, Inbred C57BLNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DOrthomyxoviridae InfectionsPneumonia, ViralReceptors, ImmunologicReceptors, Natural Killer CellConceptsInfluenza pneumoniaT cellsLung injuryTNF productionT cell-mediated clearanceQa-1bAg-specific CD8Considerable lung injurySevere influenza infectionCD94/NKG2AT cell Ag recognitionEffector cell recognitionLimit immunopathologyNKG2A blockadeAntiviral CD8Distal airwaysInfluenza infectionPulmonary pathologyTNF-alphaCD8Infectious virusAg recognitionImmunopathologyPneumoniaCell recognition
2005
Case Study Review
Noble PW, Tanoue L, Homer R. Case Study Review. CHEST Journal 2005, 128: 540s-546s. PMID: 16304245, DOI: 10.1378/chest.128.5_suppl_1.540s.Peer-Reviewed Original Research
2004
Idiopathic pulmonary fibrosis: new insights into pathogenesis
Noble PW, Homer RJ. Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clinics In Chest Medicine 2004, 25: 749-758. PMID: 15564020, DOI: 10.1016/j.ccm.2004.04.003.Peer-Reviewed Original ResearchConceptsUsual interstitial pneumoniaInterstitial pneumoniaUncontrolled lung inflammationUnique pathologic featuresProgressive clinical courseAnti-inflammatory therapyIdiopathic pulmonary fibrosisLung inflammationClinical coursePathologic featuresPulmonary fibrosisCardinal manifestationsInflammatory responseNew therapiesFibroblast functionPneumoniaPathogenesisTherapyCurrent thoughtsRecent reviewBiopsyInflammationFibrosisIPF
2003
Nonspecific Interstitial Pneumonia
Homer R. Nonspecific Interstitial Pneumonia. AJSP Review And Reports 2003, 8: 257-266. DOI: 10.1097/01.pcr.0000101943.54233.3e.Peer-Reviewed Original ResearchInterstitial lung diseaseNonspecific interstitial pneumoniaLung diseaseInterstitial pneumoniaDiffuse parenchymal lung diseaseConsensus classification systemIndividual patient prognosticationIdiopathic interstitial pneumoniaParenchymal lung diseaseTailoring of therapyPathologic featuresClinical featuresPatient prognosticationIndividual patientsPneumoniaDiseaseEuropean SocietyDistinct subgroupsSubgroupsWide spectrumClassification systemYearsPatientsTherapyClinicians
1997
Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease
Trawick D, Kotch A, Matthay R, Homer RJ. Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease. European Respiratory Journal 1997, 10: 2166-2170. PMID: 9311521, DOI: 10.1183/09031936.97.10092166.Peer-Reviewed Original ResearchConceptsInvasive pulmonary aspergillosisChronic granulomatous diseaseAcute eosinophilic pneumoniaGranulomatous diseaseEosinophilic pneumoniaPulmonary aspergillosisSecond lung biopsyAcute lung diseaseHealthy young womenInvasive AspergillusLung histopathologyImmunocompetent patientsLung biopsyLung diseasePatientsPneumoniaYoung womenDiseaseAspergillosisPresentationImmunocompetentBiopsyGranulomasHistopathologySteroids