2012
Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2
Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA. Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2. American Journal Of Respiratory Cell And Molecular Biology 2012, 46: 668-676. PMID: 22227562, PMCID: PMC3359903, DOI: 10.1165/rcmb.2011-0074oc.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryNOS/nitric oxideNitric oxideLung injuryAngiopoietin-2Pathogenesis of HALIAlveolar-capillary protein leakAcute respiratory distress syndromeHyperoxia-Induced Lung InjuryAcute lung injuryRespiratory distress syndromeImportant protective roleCell deathBronchopulmonary dysplasiaDistress syndromeSupplemental oxygenNb miceProtein leakTissue injuryProtective roleNewbornsNull micePremature deathAdult controlsAng2
2005
Bcl-2–related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury
He CH, Waxman AB, Lee CG, Link H, Rabach ME, Ma B, Chen Q, Zhu Z, Zhong M, Nakayama K, Nakayama KI, Homer R, Elias JA. Bcl-2–related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. Journal Of Clinical Investigation 2005, 115: 1039-1048. PMID: 15841185, PMCID: PMC1070412, DOI: 10.1172/jci23004.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryAcute lung injuryLung injuryIL-11Bcl-2Alveolar protein leakBcl-xLToxic effectsEpithelial cell apoptosisWT miceProtein leakMurine survivalExpression of A1Survival advantageBfl-1/A1Protective responsePremature deathHyperoxiaA1 overexpressionBcl-2 proteinMiceCell apoptosisCritical mediatorInjuryNecrosis
2003
Pulmonary Expression of Leukemia Inhibitory Factor Induces B Cell Hyperplasia and Confers Protection in Hyperoxia*
Wang J, Chen Q, Corne J, Zhu Z, Lee CG, Bhandari V, Homer RJ, Elias JA. Pulmonary Expression of Leukemia Inhibitory Factor Induces B Cell Hyperplasia and Confers Protection in Hyperoxia*. Journal Of Biological Chemistry 2003, 278: 31226-31232. PMID: 12782633, DOI: 10.1074/jbc.m301820200.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorB-cell hyperplasiaCell hyperplasiaIL-6Protective effectTransgenic miceAlveolar-capillary protein leakB cell-mediated responsesInhibitory factorAdult respiratory distress syndromeHyperoxic acute lung injuryAcute lung injuryRespiratory distress syndromeCell-mediated responsesInduction of interleukinBronchoalveolar lavage cellularityHuman leukemia inhibitory factorLung injuryDistress syndromeLavage cellularityPulmonary expressionProtein leakRespiratory effectsOxidant injuryB lymphocytes
2000
Interleukin-6–Induced Protection in Hyperoxic Acute Lung Injury
Ward N, Waxman A, Homer R, Mantell L, Einarsson O, Du Y, Elias J. Interleukin-6–Induced Protection in Hyperoxic Acute Lung Injury. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 535-542. PMID: 10783124, DOI: 10.1165/ajrcmb.22.5.3808.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsApoptosisBcl-2-Associated X ProteinBronchoalveolar Lavage FluidCells, CulturedHyperoxiaIn Situ Nick-End LabelingInterleukin-6Lipid PeroxidationLungMiceMice, TransgenicMicroscopy, ElectronProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Superoxide DismutaseTissue Inhibitor of Metalloproteinase-1ConceptsIL-6Lung injuryTransgene (-) animalsAlveolar-capillary protein leakHyperoxic acute lung injurySuperoxide dismutaseAcute lung injuryLung lipid peroxidationHyperoxic lung injurySignificant alterationsBcl-2Cell deathDNA fragmentationProtein leakManganese superoxide dismutaseProtective effectMetalloproteinase-1TIMP-1Transgenic miceTissue inhibitorInjuryZinc superoxide dismutaseMarked diminutionLipid peroxidationCytopathic response
1998
Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Journal Of Clinical Investigation 1998, 101: 1970-1982. PMID: 9576762, PMCID: PMC508784, DOI: 10.1172/jci1337.Peer-Reviewed Original ResearchConceptsIL-11Lung injuryTransgene (-) animalsIL-1Alveolar-capillary protein leakPulmonary neutrophil recruitmentAcute lung injuryHyperoxic gas mixtureDNA fragmentationLevels of totalMurine toleranceLung expressionNeutrophil recruitmentProtein leakTNF productionLung antioxidantsTransgenic miceCopper-zinc superoxide dismutaseZinc superoxide dismutaseHyperoxiaGlutathione peroxidaseLipid peroxidationInjuryOxygen toxicityDismutase activity