2020
Drug Sensitivity and Allele‐specificity of First‐line Osimertinib Resistance EGFR Mutations
Starrett J, Guernet A, Cuomo M, Poels K, van Rosenburgh I, Nagelberg A, Farnsworth D, Price K, Khan H, Ashtekar K, Gaefele M, Ayeni D, Stewart T, Kuhlmann A, Kaech S, Unni A, Homer R, Lockwood W, Michor F, Goldberg S, Lemmon M, Smith P, Cross D, Politi K. Drug Sensitivity and Allele‐specificity of First‐line Osimertinib Resistance EGFR Mutations. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00612.Peer-Reviewed Original ResearchFirst-line osimertinibEGFR-mutant lung cancerMutant lung cancerOsimertinib treatmentEGFR-TKILung cancerEGFR mutationsTotal tumorsPreferred first-line therapySecondary mutationsThird-generation EGFR-TKIFirst-line osimertinib treatmentMichael Smith FoundationResistance EGFR mutationsFirst-line therapySecondary EGFR mutationGeneration EGFR-TKISubsequent treatment approachesTransgenic mouse modelLung cancer researchTumor volume changesCoronal MR imagesTumor volume measurementsNew Investigator AwardResistance mechanisms
2013
Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection
Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R. Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection. Science 2013, 340: 1230-1234. PMID: 23618765, PMCID: PMC3933032, DOI: 10.1126/science.1233632.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 1CoinfectionDisease Models, AnimalHost-Pathogen InteractionsInterleukin-1betaLegionella pneumophilaLegionnaires' DiseaseLungMiceMice, Inbred C57BLOrthomyxoviridaeOrthomyxoviridae InfectionsPneumonia, BacterialToll-Like Receptor 2Toll-Like Receptor 3Toll-Like Receptor 4Tumor Necrosis Factor-alphaConceptsHost defenseInfluenza virusImmune resistance mechanismsSecondary bacterial pneumoniaInfluenza virus infectionViral-bacterial coinfectionsBacterial coinfectionBacterial pneumoniaVirus infectionMouse modelTissue protectionImmune systemTissue damagePathogen burdenDisease severityBacterial infectionsImpaired abilityInfectionCoinfectionResistance mechanismsVirusLegionella pneumophilaMorbidityPneumoniaFailure