2008
Acidic Mammalian Chitinase Is Secreted via an ADAM17/Epidermal Growth Factor Receptor-dependent Pathway and Stimulates Chemokine Production by Pulmonary Epithelial Cells*
Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG, Elias JA. Acidic Mammalian Chitinase Is Secreted via an ADAM17/Epidermal Growth Factor Receptor-dependent Pathway and Stimulates Chemokine Production by Pulmonary Epithelial Cells*. Journal Of Biological Chemistry 2008, 283: 33472-33482. PMID: 18824549, PMCID: PMC2586247, DOI: 10.1074/jbc.m805574200.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorLung epithelial cellsAcidic mammalian chitinaseChemokine productionEpithelial cellsT helper cell type 2 inflammationEpidermal growth factor receptor-dependent pathwayAsthma-like responsesType 2 inflammationMammalian chitinaseEpithelial cell productionReceptor-dependent pathwayPulmonary epithelial cellsEGFR-dependent pathwayGrowth factor receptorCotransfection experimentsEffector responsesParacrine fashionEGFR inhibitionSecretionFactor receptorA549 cellsAMCaseRecombinant AMCaseRegulatory effects
2001
Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1
Lee C, Homer R, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley J, Gotwals P, Noble P, Chen Q, Senior R, Elias J. Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1. Journal Of Experimental Medicine 2001, 194: 809-822. PMID: 11560996, PMCID: PMC2195954, DOI: 10.1084/jem.194.6.809.Peer-Reviewed Original ResearchConceptsIL-13Fibrogenic effectsT helper cell type 2 inflammationTissue fibrosisIL-13 overexpressionMMP-9 null miceType 2 inflammationTransforming Growth Factor-β1Wild-type miceGrowth factor-β1Pulmonary fibrosisTGF-beta pathwayFactor-β1Matrix metalloproteinasePotent stimulatorFibrosisNull miceTGFPlasminogen activatorDecreased levelsKey mediatorMiceGrowth factorUrinary plasminogen activatorProtein 1