1999
Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule
Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule. Thrombosis And Haemostasis 1999, 82: 88-92. PMID: 10456459, DOI: 10.1055/s-0037-1614634.Peer-Reviewed Original ResearchConceptsCytoplasmic domainExtracellular domainTF-VIIa complexMetastatic effectsMelanoma cellsSerine residuesTF mutantsTF actsKey residuesMutant formsTissue factorMelanoma cell linesTransmembrane glycoproteinHuman melanoma cellsHuman melanoma cell linesVascularization of tumorsCell linesBlood coagulationPhosphorylationGrowth factorTF expressionVascular endothelial growth factorExpressionResiduesMelanoma lines
1994
Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model.
Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circulation Research 1994, 75: 268-277. PMID: 8033340, DOI: 10.1161/01.res.75.2.268.Peer-Reviewed Original ResearchConceptsAntibody-treated groupBalloon angioplastyPlatelet inhibitionLuminal diameterPlatelet glycoprotein IIb/IIIa receptorControl groupGlycoprotein IIb/IIIa receptorIIb/IIIa receptorMonoclonal antibodiesPlatelet glycoprotein IIb/IIIaPotent platelet inhibitionMinimum luminal diameterInhibits platelet functionPathogenesis of restenosisGlycoprotein IIb/IIIaInfusion of salineSignificant differencesDeposition of plateletsIIb/IIIaQuantitative histological analysisSingle infusionVascular injurySecond infusionExperimental atherosclerosisFemoral artery