Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury
Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury. The Journal Of Immunology 2005, 175: 4834-4838. PMID: 16210584, DOI: 10.4049/jimmunol.175.8.4834.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisGene Transfer TechniquesGenetic Predisposition to DiseaseHeme Oxygenase-1HyperoxiaLungMiceMice, KnockoutOxidantsToll-Like Receptor 4ConceptsTLR4-deficient miceLung injuryAntioxidant gene heme oxygenase-1Gene heme oxygenase-1Oxidant lung injuryBcl-2Heme oxygenase-1Life-sustaining measuresPhospho-Akt levelsNovel mechanistic linkRespiratory failureIll patientsLung integrityMurine modelOxygenase-1Oxidant stressProtective roleHost responseInnate immunityInjuryPhospho-AktHyperoxiaConfer susceptibilityMiceMammalian TLR4Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury
Severgnini M, Takahashi S, Tu P, Perides G, Homer RJ, Jhung JW, Bhavsar D, Cochran BH, Simon AR. Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2005, 171: 858-867. PMID: 15665321, DOI: 10.1164/rccm.200407-981oc.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsCapillary Leak SyndromeEnzyme ActivationEnzyme InhibitorsEscherichia coliGene Expression RegulationGene Transfer TechniquesIndolesJanus Kinase 2LipopolysaccharidesLungMiceMice, Inbred BALB CProtein-Tyrosine KinasesProto-Oncogene ProteinsRespiratory Distress SyndromeSignal TransductionSrc-Family KinasesSulfonamidesTranscriptional ActivationTyrphostinsConceptsAcute lung injuryLung injuryCytokine productionLPS challengeSmall molecule inhibitorsLipopolysaccharide-induced acute lung injuryLethal LPS challengeLung cytokine productionSystemic cytokine productionSelective tyrosine kinase inhibitorLung vascular permeabilityMurine lung injuryTyrosine kinase inhibitorsNovel therapeutic agentsMolecule inhibitorsSuppressor of cytokineChemokine productionSystemic inhibitionAirway epitheliumVascular permeabilitySpecific small molecule inhibitorsInjurySrc kinaseTherapeutic agentsKinase inhibitors