2004
The C10/CCL6 Chemokine and CCR1 Play Critical Roles in the Pathogenesis of IL-13-Induced Inflammation and Remodeling
Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA. The C10/CCL6 Chemokine and CCR1 Play Critical Roles in the Pathogenesis of IL-13-Induced Inflammation and Remodeling. The Journal Of Immunology 2004, 172: 1872-1881. PMID: 14734772, DOI: 10.4049/jimmunol.172.3.1872.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCathepsinsChemokine CCL2Chemokines, CCDown-RegulationImmune SeraInflammationInterleukin-13LungLung ComplianceLung Volume MeasurementsMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicProtease InhibitorsPulmonary AlveoliReceptors, CCR1Receptors, ChemokineUp-RegulationConceptsIL-13-induced inflammationMatrix metalloproteinase-2IL-13Potent stimulatorMMP-9Alveolar remodelingMonocyte chemoattractant protein-1Transgenic IL-13Inflammatory protein-1alphaChemoattractant protein-1Wild-type miceIL-13 stimulationPulmonary phenotypeLevels of mRNAMetalloproteinase-4Murine lungMetalloproteinase-2Tissue inhibitorInflammationTargeted null mutationCompliance alterationsPathogenesisCCL6ChemokinesProtein 1
2000
Airway Hyperresponsiveness and Airway Obstruction in Transgenic Mice
Kuhn C, Homer R, Zhu Z, Ward N, Flavell R, Geba G, Elias J. Airway Hyperresponsiveness and Airway Obstruction in Transgenic Mice. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 289-295. PMID: 10696065, DOI: 10.1165/ajrcmb.22.3.3690.Peer-Reviewed Original ResearchConceptsLittermate control miceTransgenic miceAirway obstructionControl miceIL-11Basal airway resistanceIL-6 (-/-) miceSubepithelial airway fibrosisObstructive lung diseasePathophysiology of asthmaAirway wall thicknessAirway fibrosisAirway hyperresponsivenessAirway reactivityMethacholine responsivenessAirway physiologyAirway responsesAirspace enlargementAirway resistanceCaliber changeIL-6Lung diseaseMononuclear cellsPulmonary disordersLuminal diameter