2022
Development of an immunohistochemical assay for Siglec-15
Shafi S, Aung TN, Robbins C, Zugazagoitia J, Vathiotis I, Gavrielatou N, Yaghoobi V, Fernandez A, Niu S, Liu LN, Cusumano ZT, Leelatian N, Cole K, Wang H, Homer R, Herbst RS, Langermann S, Rimm DL. Development of an immunohistochemical assay for Siglec-15. Laboratory Investigation 2022, 102: 771-778. PMID: 35459795, PMCID: PMC9253057, DOI: 10.1038/s41374-022-00785-9.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalB7-H1 AntigenCarcinoma, Non-Small-Cell LungHumansImmunohistochemistryLung NeoplasmsSialic Acid Binding Immunoglobulin-like LectinsConceptsSiglec-15IHC assaysPD-L1PD-1/PD-L1 inhibitionPD-L1 blockadePD-L1 inhibitionHigh expressionFuture clinical trialsImmunoglobulin-type lectinsSiglec-15 expressionCompanion diagnostic assayPromising new targetTumor histologyImmunotherapeutic targetLung cancerImmune cellsClinical trialsNovel recombinant antibodiesCancer histologyImmunohistochemical assaysMyeloid cellsTumor typesScoring systemNew targetsHigh concordance
1994
Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model.
Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circulation Research 1994, 75: 268-277. PMID: 8033340, DOI: 10.1161/01.res.75.2.268.Peer-Reviewed Original ResearchConceptsAntibody-treated groupBalloon angioplastyPlatelet inhibitionLuminal diameterPlatelet glycoprotein IIb/IIIa receptorControl groupGlycoprotein IIb/IIIa receptorIIb/IIIa receptorMonoclonal antibodiesPlatelet glycoprotein IIb/IIIaPotent platelet inhibitionMinimum luminal diameterInhibits platelet functionPathogenesis of restenosisGlycoprotein IIb/IIIaInfusion of salineSignificant differencesDeposition of plateletsIIb/IIIaQuantitative histological analysisSingle infusionVascular injurySecond infusionExperimental atherosclerosisFemoral artery