2016
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science 2016, 352: 463-466. PMID: 27102485, PMCID: PMC5465864, DOI: 10.1126/science.aaf3926.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAged, 80 and overAnimalsBacterial InfectionsCaspase 1CaspasesCaspases, InitiatorFemaleHumansImmunity, InnateInfluenza A virusInfluenza, HumanInterferon-betaMaleMembrane GlycoproteinsMiceMonocytesMyxovirus Resistance ProteinsNeutrophilsOrthomyxoviridae InfectionsRespiratory Tract InfectionsToll-Like Receptor 7Viral LoadYoung AdultConceptsBacterial burdenAntiviral resistanceNeutrophil-dependent tissue damageMyD88-dependent signalingAntiviral interferon productionCaspase-1/11IAV diseaseViral loadInfluenza diseaseOlder humansTissue damageInterferon productionInflammasome responseOlder adultsTLR7Vivo consequencesDiseaseMiceIAVBurdenMx geneHumansMonocytesMortalityInfluenza
2008
Enhanced Innate Immune Responsiveness to Pulmonary Cryptococcus neoformans Infection Is Associated with Resistance to Progressive Infection
Guillot L, Carroll SF, Homer R, Qureshi ST. Enhanced Innate Immune Responsiveness to Pulmonary Cryptococcus neoformans Infection Is Associated with Resistance to Progressive Infection. Infection And Immunity 2008, 76: 4745-4756. PMID: 18678664, PMCID: PMC2546841, DOI: 10.1128/iai.00341-08.Peer-Reviewed Original ResearchConceptsSJL/J miceKC/CXCL1Cryptococcus neoformans infectionC. neoformans infectionKeratinocyte-derived chemokineNeoformans infectionJ miceInnate immune responseTNF-alphaProgressive infectionImmune responseResistant SJL/J miceMIP-2/CXCL2Pulmonary C. neoformans infectionPulmonary Cryptococcus neoformans infectionPulmonary innate immune responseSJL/J macrophagesC. neoformansInflammatory cytokine tumor necrosis factor alphaEnhanced innate immune responseMIP-1alpha/CCL3IL-12/ILMCP-1/CCL2Cytokine tumor necrosis factor alphaTumor necrosis factor alpha