2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulation
1988
Phenotypic Heterogeneity and Cytotoxic Activity of Con A and IL-2-Stimulated Cultures of Mouse Thy-1+ Epidermal Cells
Nixon-Fulton J, Hackett J, Bergstresser P, Kumar V, Tigelaar R. Phenotypic Heterogeneity and Cytotoxic Activity of Con A and IL-2-Stimulated Cultures of Mouse Thy-1+ Epidermal Cells. Journal Of Investigative Dermatology 1988, 91: 62-68. PMID: 2898506, DOI: 10.1111/1523-1747.ep12463290.Peer-Reviewed Original ResearchConceptsAntibody-dependent cell-mediated cytotoxicityYAC-1 targetsLyt-2Thy-1Asialo GM1IL-2Con AMouse Thy-1IL-2-stimulated culturesCytotoxic activityDendritic Thy-1NK-sensitive targetsNK-resistant targetsCell-mediated cytotoxicityT-cell markersShort-term cultured cellsPhenotypic heterogeneityMaximum cytotoxic activityYAC-1Interleukin-2Flow cytometryL3T4Population of cellsMouse epidermisLong-term culture