1995
Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells
Longley J, Ding T, Levin D, Lewis J, Edelson R, Tigelaar R, Flavell R. Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells. Journal Of Investigative Dermatology 1995, 104: 329-334. PMID: 7860996, DOI: 10.1111/1523-1747.ep12665365.Peer-Reviewed Original ResearchConceptsSplenic dendritic cellsEpidermal Langerhans cellsLangerhans cellsDendritic cellsE expressionClass II major histocompatibility complex moleculesLangerhans cells expressionMurine Langerhans cellsMajor histocompatibility complex moleculesNear-normal levelsB6 genetic backgroundHistocompatibility complex moleculesMajor histocompatibility complex class II gene expressionImmune functionClass II proteinsImmunoperoxidase stainingCell-specific regulatory sequencesClass II gene expressionTransgenic miceCell expressionImmunofluorescence cytometryIntact animalsDecrease expressionMajor histocompatibility genesHistocompatibility genes
1994
Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines
Tokura Y, Yagi J, O'Malley J, Lewis J, Takigawa M, Edelson R, Tigelaar R. Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines. Journal Of Investigative Dermatology 1994, 102: 31-38. PMID: 8288908, DOI: 10.1111/1523-1747.ep12371727.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialCell DivisionCells, CulturedCytokinesEnterotoxinsEnzyme-Linked Immunosorbent AssayEpidermal CellsEpidermisExfoliatinsFemaleHistocompatibility Antigens Class IIHumansInterferon-gammaInterleukin-1KeratinocytesLangerhans CellsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred CBASpleenStaphylococcus aureusSuperantigensT-LymphocytesThymus GlandTumor Necrosis Factor-alphaConceptsStaphylococcal enterotoxin BT cell responsesLangerhans cellsT cellsExfoliative toxinAccessory cellsEnterotoxin BTumor necrosisT-cell receptor V beta gene segmentsT cell-activating cytokinesMajor histocompatibility complex (MHC) class II moleculesSuperantigen staphylococcal enterotoxin BMajor histocompatibility complex classMurine epidermal Langerhans cellsT-cell proliferative activityEpidermal Langerhans cellsSplenic T cellsT cell proliferationMurine splenic T cellsHistocompatibility complex classClass II moleculesEnzyme-linked immunosorbentBeta gene segmentsImmunostimulatory moleculesImmunomodulatory cytokines
1991
Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells
Simon J, Cruz P, Tigelaar R, Sontheimer R, Bergstresser P. Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells. Journal Of Investigative Dermatology 1991, 96: 148-151. PMID: 1670950, DOI: 10.1111/1523-1747.ep12515946.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear leukocytesAdhesion molecules CD11aAlloreactive T cellsAntigen-presenting cellsLangerhans cellsT cellsICAM-1T cell activationAdhesion moleculesAccessory signalsAllogeneic peripheral blood mononuclear leukocytesHuman epidermal Langerhans cellsBlood mononuclear leukocytesEpidermal Langerhans cellsEpidermal cellsAdhesion molecule expressionTwo-color immunofluorescenceDependent T-cell activationRelevant adhesion moleculesEfficient T cell activationAllostimulatory capacityHuman epidermal cellsLC stimulationMolecule expressionMononuclear leukocytes
1990
TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue
Tigelaar R, Lewis J, Bergstresser P. TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue. Journal Of Investigative Dermatology 1990, 94: s58-s63. PMID: 1972173, DOI: 10.1111/1523-1747.ep12875138.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsGamma/delta cellsT cell antigen receptorEpidermal T cellsT cellsCD4-CD8Alpha/beta T cell antigen receptorGamma/delta typeSkin-Associated Lymphoid TissueBone marrow-derived cellsGamma/delta populationsClass II MHC moleculesDelta cellsMarrow-derived cellsTCR junctional regionsEarly fetal thymocytesMHC-like moleculesLangerhans cellsLymphoid tissueTCR heterogeneityNormal miceMHC moleculesThy-1Fetal thymocytesMHC typeLangerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity.
Cruz P, Tigelaar R, Bergstresser P. Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity. The Journal Of Immunology 1990, 144: 2486-92. PMID: 1969448, DOI: 10.4049/jimmunol.144.7.2486.Peer-Reviewed Original ResearchConceptsLow-dose UVB radiationContact hypersensitivityLangerhans cellsIntravenous infusionLow-dose ultraviolet B (UVB) radiationExposure of LCThy-1UVB radiationSuppressor signalsMesenteric lymph nodesLow-dose UVBEffector signalsSkin graft experimentsLC migrationImmunologic targetsLymph nodesAllogeneic transferCH responsesLymphoid tissueImmune responseSyngeneic miceImmunization modelImmunogenic propertiesInfusionUltraviolet B radiationUVB Radiation and DNFB Skin Painting Induce Suppressor Cells Universally in Mice
Glass M, Bergstresser P, Tigelaar R, Streilein J. UVB Radiation and DNFB Skin Painting Induce Suppressor Cells Universally in Mice. Journal Of Investigative Dermatology 1990, 94: 273-278. PMID: 1689757, DOI: 10.1111/1523-1747.ep12874117.Peer-Reviewed Original ResearchConceptsSuppressor T cellsStrains of miceContact hypersensitivityLangerhans cellsT cellsSuppressor cellsHapten-specific suppressor T cellsInduction of CHSUVB-susceptible strainsT suppressor cellsTreatment of miceAntigen-presenting cellsEpidermal Langerhans cellsEffects of UVBEffector mechanismsMurine skinMiceUVBUVB radiationSkinInductionDinitrofluorobenzeneCellsUVRApparent effect
1987
Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells
Kuziel W, Takashima A, Bonyhadi M, Bergstresser P, Allison J, Tigelaar R, Tucker P. Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells. Nature 1987, 328: 263-266. PMID: 2885757, DOI: 10.1038/328263a0.Peer-Reviewed Original ResearchConceptsEpidermal cellsT cell receptorDendritic epidermal cellsThy-1Steady-state levelsMurine Thy-1T lymphocytesCell differentiationT-cell lineageT cell differentiationDistinct populationsMost T lymphocytesRNA expressionMajor histocompatibility complexΔ complexNecessary eventΑ-chainΓ-chainMinor populationDendritic cellsLangerhans cellsExpressionCellsNormal miceHistocompatibility complex
1986
Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells.
Sullivan S, Bergstresser P, Tigelaar R, Streilein J. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. The Journal Of Immunology 1986, 137: 2460-7. PMID: 2876041, DOI: 10.4049/jimmunol.137.8.2460.Peer-Reviewed Original ResearchConceptsContact hypersensitivityBone marrow-derived populationLangerhans cellsThy-1Epicutaneous applicationInduction of CHSRegulation of CHSDendritic epidermal cellsRoute of immunizationEpidermal Langerhans cellsSpecific unresponsivenessAntigenic encounterCH responsesImmunogenic signalsSyngeneic miceImmunogenic capacityAntigenic signalIntact skinMouse skinCellular elementsEpidermal cellsHypersensitivityMiceCell typesInductionThy-1+ epidermal cells proliferate in response to concanavalin A and interleukin 2.
Nixon-Fulton J, Bergstresser P, Tigelaar R. Thy-1+ epidermal cells proliferate in response to concanavalin A and interleukin 2. The Journal Of Immunology 1986, 136: 2776-86. PMID: 2870120, DOI: 10.4049/jimmunol.136.8.2776.Peer-Reviewed Original ResearchConceptsPeripheral T cellsIL-2Langerhans cellsRat IL-2T cellsThy-1Con AAnti-T cell reagentsMature peripheral T cellsAKR/J miceComplement depletion studiesT-cell markersConcanavalin AFluorescence-activated cell sorterThy-1 antigenNK cellsMice 20Lyt-1Lyt-2J miceInterleukin-2Maximal responseMouse epidermal cellsAsialo GM1Day 5
1985
Origin and Function of Thy-1+ Dendritic Epidermal Cells in Mice
Bergstresser P, Sullivan S, Streilein J, Tigelaar R. Origin and Function of Thy-1+ Dendritic Epidermal Cells in Mice. Journal Of Investigative Dermatology 1985, 85: s85-s90. PMID: 2409184, DOI: 10.1111/1523-1747.ep12275516.Peer-Reviewed Original ResearchConceptsLangerhans cellsFluorescence Activated Cell SorterDendritic epidermal cellsNatural suppressor cellsNatural killer cellsAntigen-presenting cellsEpidermal Langerhans cellsCells/mm2Bone marrow originThy-1 antigenNormal mouse skinCell surface determinantsBone marrow cellsSuppressor cellsCutaneous sitesDendritic cellsKiller cellsMonoclonal antibody 20T lymphocytesLymphoreticular cellsMarrow originAsialo GM1Vascular sourceThy-1Marrow cells
1984
Thy-1 Antigen-Bearing Dendritic Cells in Murine Epidermis Are Derived from Bone Marrow Precursors
Bergstresser P, Tigelaar R, Streilein J. Thy-1 Antigen-Bearing Dendritic Cells in Murine Epidermis Are Derived from Bone Marrow Precursors. Journal Of Investigative Dermatology 1984, 83: 83-87. PMID: 6147381, DOI: 10.1111/1523-1747.ep12262587.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntigens, SurfaceBone MarrowBone Marrow CellsBone Marrow TransplantationCell MovementEpidermal CellsEpidermisFluorescent Antibody TechniqueHematopoietic Stem CellsIsoantibodiesLangerhans CellsMiceMice, Inbred AKRMice, Inbred DBARadiation ChimeraSkin TransplantationThy-1 AntigensConceptsLangerhans cellsBone marrow precursorsThy-1 antigenMurine epidermisThy-1Thy-1.2Anti-I-Ad antibodiesMarrow precursorsRecipient-derived cellsBone marrow chimerasDendritic Langerhans cellsNormal skin epidermisNormal murine epidermisAKR recipientsGraft epidermisDendritic cellsHematogenous cellsDonor originSystemic availabilityAKR miceSame graftLethal irradiationLymphoid cellsAbdominal skinGraft
1983
Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.
Elmets C, Bergstresser P, Tigelaar R, Wood P, Streilein J. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. Journal Of Experimental Medicine 1983, 158: 781-794. PMID: 6193234, PMCID: PMC2187099, DOI: 10.1084/jem.158.3.781.Peer-Reviewed Original ResearchConceptsTolerogenic signalsLow-dose ultraviolet B (UVB) radiationLow-dose ultraviolet radiationAntigen-presenting potentialAntigen-specific unresponsivenessResident Langerhans cellsMechanism of unresponsivenessSuppressor cellsContact hypersensitivityLyt-1Effector stageLangerhans cellsSystemic administrationT cellsLocal applicationUltraviolet B radiationInduction phaseB radiationUnresponsivenessSkinUltraviolet radiationCellsTolerogenDNFBHypersensitivityThy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis
Bergstresser P, Tigelaar R, Dees J, Streilein J. Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis. Journal Of Investigative Dermatology 1983, 81: 286-288. PMID: 6136547, DOI: 10.1111/1523-1747.ep12518332.Peer-Reviewed Original ResearchConceptsLangerhans cellsMurine epidermisCutaneous T-cell lymphomaEar epidermisDendritic cell populationsStrain BALB/cT-cell lymphomaEpidermal Langerhans cellsThy-1.2 antigenBALB/cCell populationsThy-1 antigenT lymphocytesIa antigensDistinct cell populationsMalignant counterpartsThy-1Monoclonal antibodiesStrain B10.AAntigenMelanocytesImmunofluorescence microscopySkin surfaceEpidermisMature melanocytes