1991
Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene
Kuziel W, Lewis J, Nixon‐Fulton J, Tigelaar R, Tucker P. Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene. European Journal Of Immunology 1991, 21: 1563-1566. PMID: 1828429, DOI: 10.1002/eji.1830210635.Peer-Reviewed Original ResearchConceptsAntibody-dependent cellular cytotoxicityNatural killer cellsT cellsKiller cellsCellular cytotoxicityReceptor IITcR gamma/delta T cellsGamma/delta T cellsLectin-dependent cellular cytotoxicityShort-term bulk culturesHuman natural killer cellsMouse natural killer (NK) cellsLong-term clonesR alphaEpidermal T cellsDelta T cellsFcγ receptor IIFc gamma receptor IIFc gamma RIICD16 expressionGamma RIIBulk culturesCell populationsNorthern blot analysisBlot analysis
1989
Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody.
Havran W, Grell S, Duwe G, Kimura J, Wilson A, Kruisbeek A, O'Brien R, Born W, Tigelaar R, Allison J. Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 4185-4189. PMID: 2726770, PMCID: PMC287415, DOI: 10.1073/pnas.86.11.4185.Peer-Reviewed Original ResearchPhenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones.
Havran W, Poenie M, Tigelaar R, Tsien R, Allison J. Phenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones. The Journal Of Immunology 1989, 142: 1422-8. PMID: 2783942, DOI: 10.4049/jimmunol.142.5.1422.Peer-Reviewed Original ResearchConceptsIL-2R expressionThy-1TCR complexSecretion of lymphokinesRelease of lymphokinesGamma delta TCRIntracellular free calciumEffect of antibodiesFunctional TCR complexDendritic cellsLy-6CPharmacologic agentsNormal miceT cellsCytolytic activityDelta TCRFree calciumGamma deltaAlpha betaDEC cellsCD3 complexEpidermal clonesProtein kinase CActivation signalsLymphokines
1988
Effect of Keratinocyte Cytokines on Thy‐1+ Dendritic Epidermal Cells
TIGELAAR R, NIXON‐FULTON J, TAKASHIMA A, KUZIEL W, TAKIJIRI C, LEWIS J, TUCKER P, BERGSTRESSER P. Effect of Keratinocyte Cytokines on Thy‐1+ Dendritic Epidermal Cells. Annals Of The New York Academy Of Sciences 1988, 548: 271-282. PMID: 2470301, DOI: 10.1111/j.1749-6632.1988.tb18815.x.Peer-Reviewed Original Research
1986
Thy-1+ epidermal cells proliferate in response to concanavalin A and interleukin 2.
Nixon-Fulton J, Bergstresser P, Tigelaar R. Thy-1+ epidermal cells proliferate in response to concanavalin A and interleukin 2. The Journal Of Immunology 1986, 136: 2776-86. PMID: 2870120, DOI: 10.4049/jimmunol.136.8.2776.Peer-Reviewed Original ResearchConceptsPeripheral T cellsIL-2Langerhans cellsRat IL-2T cellsThy-1Con AAnti-T cell reagentsMature peripheral T cellsAKR/J miceComplement depletion studiesT-cell markersConcanavalin AFluorescence-activated cell sorterThy-1 antigenNK cellsMice 20Lyt-1Lyt-2J miceInterleukin-2Maximal responseMouse epidermal cellsAsialo GM1Day 5
1985
Origin and Function of Thy-1+ Dendritic Epidermal Cells in Mice
Bergstresser P, Sullivan S, Streilein J, Tigelaar R. Origin and Function of Thy-1+ Dendritic Epidermal Cells in Mice. Journal Of Investigative Dermatology 1985, 85: s85-s90. PMID: 2409184, DOI: 10.1111/1523-1747.ep12275516.Peer-Reviewed Original ResearchConceptsLangerhans cellsFluorescence Activated Cell SorterDendritic epidermal cellsNatural suppressor cellsNatural killer cellsAntigen-presenting cellsEpidermal Langerhans cellsCells/mm2Bone marrow originThy-1 antigenNormal mouse skinCell surface determinantsBone marrow cellsSuppressor cellsCutaneous sitesDendritic cellsKiller cellsMonoclonal antibody 20T lymphocytesLymphoreticular cellsMarrow originAsialo GM1Vascular sourceThy-1Marrow cells
1984
Thy-1 Antigen-Bearing Dendritic Cells in Murine Epidermis Are Derived from Bone Marrow Precursors
Bergstresser P, Tigelaar R, Streilein J. Thy-1 Antigen-Bearing Dendritic Cells in Murine Epidermis Are Derived from Bone Marrow Precursors. Journal Of Investigative Dermatology 1984, 83: 83-87. PMID: 6147381, DOI: 10.1111/1523-1747.ep12262587.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntigens, SurfaceBone MarrowBone Marrow CellsBone Marrow TransplantationCell MovementEpidermal CellsEpidermisFluorescent Antibody TechniqueHematopoietic Stem CellsIsoantibodiesLangerhans CellsMiceMice, Inbred AKRMice, Inbred DBARadiation ChimeraSkin TransplantationThy-1 AntigensConceptsLangerhans cellsBone marrow precursorsThy-1 antigenMurine epidermisThy-1Thy-1.2Anti-I-Ad antibodiesMarrow precursorsRecipient-derived cellsBone marrow chimerasDendritic Langerhans cellsNormal skin epidermisNormal murine epidermisAKR recipientsGraft epidermisDendritic cellsHematogenous cellsDonor originSystemic availabilityAKR miceSame graftLethal irradiationLymphoid cellsAbdominal skinGraft
1973
SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Tigelaar R, Asofsky R. SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE. Journal Of Experimental Medicine 1973, 137: 239-253. PMID: 4405532, PMCID: PMC2139477, DOI: 10.1084/jem.137.2.239.Peer-Reviewed Original ResearchConceptsThymus-derived cellsAdult syngeneic recipientsAnti-theta antibodyPeripheral lymph nodesNormal adult miceNormal lymphoid tissuesElicit graftGraft-VersusGVH reactionGVH reactivityLymph nodesRecipient spleensSpleen weightSyngeneic recipientsLymphoid tissueSpleen cellsLymphoid cellsAdult miceHost reactionHost responseNormal populationDistinct subpopulationsSubpopulationsFunctional heterogeneitySpleen