1994
Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines
Tokura Y, Yagi J, O'Malley J, Lewis J, Takigawa M, Edelson R, Tigelaar R. Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines. Journal Of Investigative Dermatology 1994, 102: 31-38. PMID: 8288908, DOI: 10.1111/1523-1747.ep12371727.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialCell DivisionCells, CulturedCytokinesEnterotoxinsEnzyme-Linked Immunosorbent AssayEpidermal CellsEpidermisExfoliatinsFemaleHistocompatibility Antigens Class IIHumansInterferon-gammaInterleukin-1KeratinocytesLangerhans CellsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred CBASpleenStaphylococcus aureusSuperantigensT-LymphocytesThymus GlandTumor Necrosis Factor-alphaConceptsStaphylococcal enterotoxin BT cell responsesLangerhans cellsT cellsExfoliative toxinAccessory cellsEnterotoxin BTumor necrosisT-cell receptor V beta gene segmentsT cell-activating cytokinesMajor histocompatibility complex (MHC) class II moleculesSuperantigen staphylococcal enterotoxin BMajor histocompatibility complex classMurine epidermal Langerhans cellsT-cell proliferative activityEpidermal Langerhans cellsSplenic T cellsT cell proliferationMurine splenic T cellsHistocompatibility complex classClass II moleculesEnzyme-linked immunosorbentBeta gene segmentsImmunostimulatory moleculesImmunomodulatory cytokines
1992
Expression of mouse Tla region class I genes in tissue enriched for γδ cells
Eghtesady P, Brorson K, Cheroutre H, Tigelaar R, Hood L, Kronenberg M. Expression of mouse Tla region class I genes in tissue enriched for γδ cells. Immunogenetics 1992, 36: 377-388. PMID: 1388139, DOI: 10.1007/bf00218045.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBase SequenceBlotting, NorthernDNA ProbesFetusGene ExpressionGenes, MHC Class IMiceMice, Inbred BALB CMice, Inbred C57BLMolecular Sequence DataMultigene FamilyPolymerase Chain ReactionReceptors, Antigen, T-Cell, gamma-deltaRepetitive Sequences, Nucleic AcidT-LymphocytesConceptsΓδ T cellsT cellsPolymerase chain reactionTla region genesClass IΓδ T lymphocytesPresentation of antigensThymus leukemia antigenMajor histocompatibility complexRegion gene productsΓδ cellsLeukemia antigenAntigen presentationT lymphocytesRegion genesFetal tissuesTL antigensMouse major histocompatibility complexMonoclonal antibodiesHistocompatibility complexPattern of expressionAntigenChain reactionRecent evidenceNorthern blot analysisPeptidergic Neurons and Vasoactive Intestinal Peptide Modulate Experimental Delayed‐Type Hypersensitivity Reactionsa
GIROLOMONI G, TIGELAAR R. Peptidergic Neurons and Vasoactive Intestinal Peptide Modulate Experimental Delayed‐Type Hypersensitivity Reactionsa. Annals Of The New York Academy Of Sciences 1992, 650: 9-12. PMID: 1605501, DOI: 10.1111/j.1749-6632.1992.tb49087.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapsaicinDermatitis, ContactHypersensitivity, DelayedMiceMice, Inbred BALB CNeuroimmunomodulationNeuropeptidesVasoactive Intestinal Peptide
1991
Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene
Kuziel W, Lewis J, Nixon‐Fulton J, Tigelaar R, Tucker P. Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene. European Journal Of Immunology 1991, 21: 1563-1566. PMID: 1828429, DOI: 10.1002/eji.1830210635.Peer-Reviewed Original ResearchConceptsAntibody-dependent cellular cytotoxicityNatural killer cellsT cellsKiller cellsCellular cytotoxicityReceptor IITcR gamma/delta T cellsGamma/delta T cellsLectin-dependent cellular cytotoxicityShort-term bulk culturesHuman natural killer cellsMouse natural killer (NK) cellsLong-term clonesR alphaEpidermal T cellsDelta T cellsFcγ receptor IIFc gamma receptor IIFc gamma RIICD16 expressionGamma RIIBulk culturesCell populationsNorthern blot analysisBlot analysis
1990
Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions.
Girolomoni G, Tigelaar R. Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions. The Journal Of Immunology 1990, 145: 1105-12. PMID: 2380551, DOI: 10.4049/jimmunol.145.4.1105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapsaicinDermatitis, ContactFemaleHypersensitivity, DelayedLymph NodesMast CellsMiceMice, Inbred BALB CNeurons, AfferentNeuropeptidesPainConceptsDelayed-type hypersensitivity reactionPrimary sensory neuronsHypersensitivity reactionsSensory neuronsCapsaicin-sensitive primary sensory neuronsBALB/c miceCapsaicin-pretreated miceEffector T cellsContact sensitivity reactionAdoptive transfer experimentsCutaneous inflammatory reactionsTopical capsaicinCapsaicin pretreatmentNeurogenic inflammationC miceNeuropeptide releaseHistologic studyInflammatory reactionT cellsPeptidergic neuronsIrritant reactionsSensitivity reactionsSuch neuronsCapsaicinPotent modulator
1989
Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody.
Havran W, Grell S, Duwe G, Kimura J, Wilson A, Kruisbeek A, O'Brien R, Born W, Tigelaar R, Allison J. Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 4185-4189. PMID: 2726770, PMCID: PMC287415, DOI: 10.1073/pnas.86.11.4185.Peer-Reviewed Original Research
1988
Thy-1+ epidermal cells in nude mice are distinct from their counterparts in thymus-bearing mice. A study of morphology, function, and T cell receptor expression.
Nixon-Fulton J, Kuziel W, Santerse B, Bergstresser P, Tucker P, Tigelaar R. Thy-1+ epidermal cells in nude mice are distinct from their counterparts in thymus-bearing mice. A study of morphology, function, and T cell receptor expression. The Journal Of Immunology 1988, 141: 1897-903. PMID: 2902136, DOI: 10.4049/jimmunol.141.6.1897.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBlotting, NorthernBlotting, SouthernCell DivisionConcanavalin ADendritic CellsEpidermal CellsEpidermisEthersFemaleInterleukin-2IonomycinMaleMiceMice, Inbred BALB CMice, Inbred CBAMice, NudeReceptors, Antigen, T-CellSpecies SpecificityTetradecanoylphorbol AcetateThy-1 AntigensThymus GlandConceptsIL-2Thy-1Nude miceNormal miceLow-dose IL-2BALB/c miceT cell receptor expressionModest proliferative responseThymus-bearing miceCell receptor expressionT cell differentiationTCR-gamma transcriptsC miceReceptor expressionAthymic miceProliferative responseNormal animalsTCR mRNACalcium ionophoreEpidermal cellsMiceNormal CBACon AFollicular epitheliumPopulation of cells
1985
Conjugated avidin binds to mast cell granules.
Tharp M, Seelig L, Tigelaar R, Bergstresser P. Conjugated avidin binds to mast cell granules. Journal Of Histochemistry & Cytochemistry 1985, 33: 27-32. PMID: 2578142, DOI: 10.1177/33.1.2578142.Peer-Reviewed Original Research
1984
The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes
Piepkorn M, Tigelaar R. The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes. Journal Of Investigative Dermatology 1984, 83: 281-285. PMID: 6237158, DOI: 10.1111/1523-1747.ep12340368.Peer-Reviewed Original ResearchConceptsMycosis fungoidesT cellsHelper/inducer T cellsCutaneous T-cell lymphomaT cell surface phenotypeInducer T cellsBALB/c originT-cell lymphomaMalignant T cellsLymphoid cell subsetsEosin-stained sectionsCenter of tumorT cell linesCytotoxic markersSézary syndromeCell subsetsBenign dermatosesDermal-epidermal junctionEpidermal necrosisParallel groupIntradermal injectionT lymphocytesSyngeneic miceSurface phenotypeLymphoid cellsConjugated Avidin Identifies Cutaneous Rodent and Human Mast Cells
Bergstresser P, Tigelaar R, Tharp M. Conjugated Avidin Identifies Cutaneous Rodent and Human Mast Cells. Journal Of Investigative Dermatology 1984, 83: 214-218. PMID: 6470526, DOI: 10.1111/1523-1747.ep12263584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAscitesAvidinFluorescent DyesGuinea PigsHumansMast CellsMiceMice, Inbred BALB COvalbuminRatsRats, Inbred StrainsSkinSpecies SpecificityConceptsMast cellsMast cell granulesMast cell-deficient miceMetachromatic stainsCell-deficient miceRat peritoneal mast cellsDermal mast cellsMast cell distributionTissue mast cellsConjugated avidinHuman mast cellsPeritoneal mast cellsCell granulesSites of inflammationFluorescent dye rhodamineGuinea pig skinMethod of fixationMast cell identificationHypersensitivity reactionsHuman skin specimens
1983
Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies.
Ray M, Tharp M, Sullivan T, Tigelaar R. Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies. The Journal Of Immunology 1983, 131: 1096-102. PMID: 6193174, DOI: 10.4049/jimmunol.131.3.1096.Peer-Reviewed Original ResearchConceptsContact hypersensitivity reactionHypersensitivity reactionsDNFB challengeUnsensitized controlsAntigen challengeReactive haptenMonoclonal IgE anti-DNP antibodyIgE anti-DNP antibodyIgE anti-hapten antibodyBALB/c miceAllergic contact dermatitis reactionsBiphasic patternIgE-sensitized miceEars of miceCutaneous hypersensitivity reactionsCutaneous hypersensitivity responseCutaneous inflammatory reactionsContact dermatitis reactionsFailure of miceAnti-hapten antibodiesAnti-DNP antibodiesEar challengeEar swellingHypersensitivity responseIgE antibodiesThy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis
Bergstresser P, Tigelaar R, Dees J, Streilein J. Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis. Journal Of Investigative Dermatology 1983, 81: 286-288. PMID: 6136547, DOI: 10.1111/1523-1747.ep12518332.Peer-Reviewed Original ResearchConceptsLangerhans cellsMurine epidermisCutaneous T-cell lymphomaEar epidermisDendritic cell populationsStrain BALB/cT-cell lymphomaEpidermal Langerhans cellsThy-1.2 antigenBALB/cCell populationsThy-1 antigenT lymphocytesIa antigensDistinct cell populationsMalignant counterpartsThy-1Monoclonal antibodiesStrain B10.AAntigenMelanocytesImmunofluorescence microscopySkin surfaceEpidermisMature melanocytes
1982
Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity.
Tigelaar R, Bergstresser P, Lonsberry L, Elmets C, Wood P, Streilen J. Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity. The Journal Of Immunology 1982, 129: 1898-904. PMID: 6749982, DOI: 10.4049/jimmunol.129.5.1898.Peer-Reviewed Original Research
1975
Graft-versus-host reactivity of mouse thymocytes: Effect of in vitro treatment with anti-TL serum
Tigelaar R, Gershon R, Asofsky R. Graft-versus-host reactivity of mouse thymocytes: Effect of in vitro treatment with anti-TL serum. Cellular Immunology 1975, 19: 58-64. PMID: 241492, DOI: 10.1016/0008-8749(75)90291-9.Peer-Reviewed Original ResearchConceptsNormal mouse serumGVH reactionHost reactivityThymus-derived cellsCapacity of thymocytesPeripheral blood leukocytesSpleen weightMechanism of synergyPeripheral lymphocytesF1 miceBlood leukocytesMouse serumThymocytesSerumMouse thymocytesGraftSpecific eliminationReactivity presentTreatmentCellsLymphocytesLeukocytesMice
1973
SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Tigelaar R, Asofsky R. SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE. Journal Of Experimental Medicine 1973, 137: 239-253. PMID: 4405532, PMCID: PMC2139477, DOI: 10.1084/jem.137.2.239.Peer-Reviewed Original ResearchConceptsThymus-derived cellsAdult syngeneic recipientsAnti-theta antibodyPeripheral lymph nodesNormal adult miceNormal lymphoid tissuesElicit graftGraft-VersusGVH reactionGVH reactivityLymph nodesRecipient spleensSpleen weightSyngeneic recipientsLymphoid tissueSpleen cellsLymphoid cellsAdult miceHost reactionHost responseNormal populationDistinct subpopulationsSubpopulationsFunctional heterogeneitySpleenGraft-vs-host reactivity of mouse thymocytes: effect of cortisone pretreatment of donors.
Tigelaar R, Asofsky R. Graft-vs-host reactivity of mouse thymocytes: effect of cortisone pretreatment of donors. The Journal Of Immunology 1973, 110: 567-74. PMID: 4405321, DOI: 10.4049/jimmunol.110.2.567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCortisoneGraft vs Host ReactionImmunity, CellularLymph NodesMiceMice, Inbred BALB COrgan SizeRadiation ChimeraSpleenT-LymphocytesConceptsSpleen weightNormal thymocytesPeripheral lymph node cellsCell-mediated immune reactionsBALB/c miceLymph node cellsThymus-derived cellsCortisone-resistant thymocytesLymphoid cell populationsCortisone pretreatmentGVH reactivityHost reactivityC miceNode cellsNormal donorsImmune reactionsThymus cellsCortisone acetateCumulative mortalityThymocytesMortalityUnique populationCell populationsMouse thymocytesDistinct cell types