2000
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
Herrick C, MacLeod H, Glusac E, Tigelaar R, Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. Journal Of Clinical Investigation 2000, 105: 765-775. PMID: 10727445, PMCID: PMC377464, DOI: 10.1172/jci8624.Peer-Reviewed Original ResearchConceptsTh2 responsesIL-13IL-4Th2-type immune responseIL-4-deficient miceTh2-promoting cytokinesOVA-specific IgG1Bronchoalveolar lavage fluidWild-type miceAllergen encounterTh2 sensitizationAirway challengeTh2 activationAllergen exposureAtopic individualsBAL fluidEnvironmental allergensWT miceLavage fluidPrimary exposureVivo depletionAnatomic sitesImmune responseAnimal modelsMice
1985
Conjugated avidin binds to mast cell granules.
Tharp M, Seelig L, Tigelaar R, Bergstresser P. Conjugated avidin binds to mast cell granules. Journal Of Histochemistry & Cytochemistry 1985, 33: 27-32. PMID: 2578142, DOI: 10.1177/33.1.2578142.Peer-Reviewed Original Research
1984
Conjugated Avidin Identifies Cutaneous Rodent and Human Mast Cells
Bergstresser P, Tigelaar R, Tharp M. Conjugated Avidin Identifies Cutaneous Rodent and Human Mast Cells. Journal Of Investigative Dermatology 1984, 83: 214-218. PMID: 6470526, DOI: 10.1111/1523-1747.ep12263584.Peer-Reviewed Original ResearchConceptsMast cellsMast cell granulesMast cell-deficient miceMetachromatic stainsCell-deficient miceRat peritoneal mast cellsDermal mast cellsMast cell distributionTissue mast cellsConjugated avidinHuman mast cellsPeritoneal mast cellsCell granulesSites of inflammationFluorescent dye rhodamineGuinea pig skinMethod of fixationMast cell identificationHypersensitivity reactionsHuman skin specimens