2006
Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract
Yono M, Foster HE, Weiss RM, Latifpour J. Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract. Journal Of Urology 2006, 176: 1214-1219. PMID: 16890728, DOI: 10.1016/j.juro.2006.04.038.Peer-Reviewed Original ResearchConceptsRat genitourinary tractLower urinary tract symptomsUrinary tract symptomsBenign prostatic hyperplasiaAdrenoceptor antagonistGenitourinary tractTract symptomsBladder baseProstatic hyperplasiaDorsolateral prostateYoung ratsIsolated muscle bathMaximum contractile responseTranscriptase-polymerase chain reaction techniqueRadioligand receptor bindingReverse transcriptase-polymerase chain reaction techniqueSignificant age-dependent differencesAge-dependent differencesAge related changesHigher body weightAge related differencesContractile responseAdrenoceptor densityAdrenoceptor subtypesBladder domeAge‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract
Yono M, Foster H, Yoshida M, Ueda S, Weiss R, Latifpour J. Age‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract. The FASEB Journal 2006, 20: a254-a254. DOI: 10.1096/fasebj.20.4.a254-a.Peer-Reviewed Original ResearchLower urinary tract symptomsRat genitourinary tractBenign prostatic hyperplasiaΑ1-AR antagonistsAge-related changesMonth old ratsGenitourinary tractOld ratsBladder baseBladder domeDorsolateral prostateVentral prostateUrinary tract symptomsMaximum contractile responseLow testosterone levelsRadioligand receptor bindingSignificant age-dependent differencesReal-time RT-PCR techniqueAge-dependent differencesHigher body weightRT-PCR techniqueTract symptomsContractile responseOlder patientsSubtype mRNAs
1999
Developmental aspects of endothelin receptors in rabbit lower urinary tract
Saito M, Latifpour J, Weiss R. Developmental aspects of endothelin receptors in rabbit lower urinary tract. Neurourology And Urodynamics 1999, 19: 71-85. PMID: 10602249, DOI: 10.1002/(sici)1520-6777(2000)19:1<71::aid-nau8>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsLower urinary tractRabbit lower urinary tractEndothelin receptorsUrinary tractBladder baseBladder domeMale rabbitsEndothelin receptor subtypesAge-related alterationsOld male rabbitsET receptorsReceptor subtypesPharmacological characterizationPharmacological profileAged rabbitsSubtype specificityReceptorsTractDevelopment-related changesSimilar proportionsWeeksReceptor compoundsUrethraRabbitsRank order
1997
Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721. PMID: 8996405, DOI: 10.1016/s0022-5347(01)65257-1.Peer-Reviewed Original ResearchConceptsCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethraEvidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721.. DOI: 10.1097/00005392-199702000-00095.Peer-Reviewed Original ResearchCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethra
1995
Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract
Latifpour J, Fukumoto Y, Weiss R. Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract. Naunyn-Schmiedeberg's Archives Of Pharmacology 1995, 352: 459-468. PMID: 8751073, DOI: 10.1007/bf00169378.Peer-Reviewed Original ResearchConceptsBladder baseSarafotoxin S6cBladder domeUrinary tractETB receptorsET-3Rabbit urinary tractSubtype specificityBQ-123Endothelin receptorsET receptorsReceptor subtypesET-1Human ETASelective ETA receptor antagonistSelective ETB agonistETA receptor antagonistETB receptor subtypesSingle receptor subtypeETA receptorsETB agonistChinese hamster ovary KReceptor antagonistSimilar binding studiesUrethra
1993
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract
Yoshida M, Latifpour J, Weiss R. Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract. European Journal Of Pharmacology 1993, 232: 159-167. PMID: 8385616, DOI: 10.1016/0014-2999(93)90769-e.Peer-Reviewed Original ResearchConceptsLower urinary tractBladder baseBladder domeUrinary tractChannel antagonistsRabbit lower urinary tractBay K 8644Channel antagonist receptorsAge-dependent changesDensity of Ca2Age-related changesAntagonist binding sitesReceptor densityPharmacological profileAntagonist receptorsRabbit urethraUrethraAge groupsBmax valuesDays rabbitsAntagonistTractWeeksRank orderBinding sites
1990
Autonomic receptors in urinary tract: sex and age differences.
Latifpour J, Kondo S, O'Hollaren B, Morita T, Weiss R. Autonomic receptors in urinary tract: sex and age differences. Journal Of Pharmacology And Experimental Therapeutics 1990, 253: 661-7. PMID: 2338651.Peer-Reviewed Original ResearchConceptsAlpha-2 adrenergic receptorsBladder domeBladder baseBeta-adrenergic receptorsAdrenergic receptorsCholinergic receptorsMuscarinic receptorsUrinary tractAlpha-2 adrenergic receptor densityLower urinary tract smooth muscleUrinary tract smooth muscleRabbit bladder baseAlpha 2A subtypeMuscarinic cholinergic receptorsAdrenergic receptor densityLower urinary tractSelective adrenergic agonistsAdult rat cortexNeonatal rat lungBeta-2 adrenergic receptorsAutonomic receptorsAge-related differencesRat cortexAdrenergic agonistsMale urethra
1989
Characterization of Autonomic Receptors in Neonatal Urinary Tract Smooth Muscle
Latifpour J, Morita T, O'Hollaren B, Kondo S, Weiss R. Characterization of Autonomic Receptors in Neonatal Urinary Tract Smooth Muscle. Neonatology 1989, 13: 1-10. PMID: 2570683, DOI: 10.1159/000457575.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic AgonistsAnimalsAnimals, NewbornCarbacholClonidineDihydroalprenololDose-Response Relationship, DrugIn Vitro TechniquesMuscle ContractionMuscle, SmoothPrazosinQuinuclidinyl BenzilateRabbitsReceptors, Adrenergic, alphaReceptors, Adrenergic, betaReceptors, MuscarinicUrinary TractYohimbineConceptsUrinary tract smooth muscleSmooth muscleAutonomic receptorsBeta-adrenergic receptor densityAlpha-1 adrenergic receptorsNeonatal urinary tractAlpha 2 receptorsAlpha 1 receptorsAlpha-adrenergic agonistsFunctional muscarinic receptorsRelaxant responsesBladder baseBladder domeMuscarinic receptorsUrinary tractReceptor densityAdult rabbitsAlpha 2ReceptorsMuscleAgonistsRank orderRabbitsHigher numberIsoproterenol