2013
Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer
Martin DT, Hoimes CJ, Kaimakliotis HZ, Cheng CJ, Zhang K, Liu J, Wheeler MA, Kelly WK, Tew GN, Saltzman WM, Weiss RM. Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. Nanomedicine Nanotechnology Biology And Medicine 2013, 9: 1124-1134. PMID: 23764660, PMCID: PMC3815967, DOI: 10.1016/j.nano.2013.05.017.Peer-Reviewed Original ResearchConceptsHistone deacetylase inhibitor belinostatBladder cancerBladder permeability barrierNon-invasive bladder cancerCultured bladder cancer cellsBladder cancer cellsChemotherapy efficacyIntravesical drug deliveryXenograft tumorsMouse bladderMouse modelConvincing dataHuman ureterBelinostatCancerCancer cellsLower IC50TumorsAcetyl-H4Tissue penetrationCLINICAL EDITORIntracellular uptakeDeliveryCellsPatients
2005
Regulation of cyclic nucleotides in the urinary tract
Wheeler MA, Ayyagari RR, Wheeler GL, Weiss RM. Regulation of cyclic nucleotides in the urinary tract. Journal Of Smooth Muscle Research 2005, 41: 1. PMID: 15855736, DOI: 10.1540/jsmr.41.1.Peer-Reviewed Original ResearchConceptsUrinary tractRelaxation responseLow compliance bladderSmooth muscle functionG proteinsCyclic AMP productionStimulatory G proteinCyclic nucleotide levelsG protein isoformsUrge incontinenceTreatment optionsProstate cancerMuscle functionDisease processFamily of phosphodiesterasesSpecific PDE inhibitorsAMP productionPDE inhibitorsBladderAdenylyl cyclasePDE isoformsTractPharmacological potentialCancerPDE expression