2021
Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis
He S, Li G, Schätzlein AG, Humphrey PA, Weiss RM, Uchegbu IF, Martin DT. Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis. Cellular Signalling 2021, 81: 109931. PMID: 33529758, DOI: 10.1016/j.cellsig.2021.109931.Peer-Reviewed Original ResearchConceptsBladder cancer cellsCancer cellsHuman bladder cancer specimensCisplatin-based chemotherapyBladder cancer treatmentBladder cancer specimensChemoresistant bladder cancer cellsBreast cancer cellsCell viabilityBladder cancerCancer specimensSmall molecule inhibitorsLevels of Ku70Cancer treatmentKu70 expression
2015
Blocking Glycoprotein‐130 Pathway Decreases Bladder Cancer Growth
Martin D, Steinbach J, Saltzman W, Weiss R. Blocking Glycoprotein‐130 Pathway Decreases Bladder Cancer Growth. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.889.11.Peer-Reviewed Original ResearchBacillus Calmette-GuerinExpression of gp130Bladder cancer cellsBladder cancerCancer specimensNon-muscle invasive bladder cancerCancer cellsEffective adjuvant agentInvasive bladder cancerWeeks of treatmentBladder cancer tissue microarrayBladder cancer growthComprehensive cancer centerBladder cancer specimensCancer tissue microarrayHuman bladder cancerAdjuvant agentBladder tumorsCancer CenterCytokeratin 20Signal transduction pathwaysCalmette-GuerinTumor gradeTissue microarrayCarcinoma markers