2007
Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra
Wada Y, Takahashi W, Latifpour J, Yamada, Kai N, Honda J, Nakanishi J, Weiss RM. Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra. BJU International 2007, 100: 430-437. PMID: 17559559, DOI: 10.1111/j.1464-410x.2007.07064.x.Peer-Reviewed Original ResearchConceptsContractile responseET receptor subtypesMaximum contractile responseProstatic urethraReceptor subtypesET-3ET receptorsET-1High-affinity binding sitesConcentration-dependent contractile responsesSubtype specificityEndothelin receptor subtypesSmooth muscle stripsReceptor-binding techniquesRegion-specific differencesEndothelin receptorsMuscle stripsRegional differencesDistal regionUrethraSubtypesReceptorsBQ123Low affinity constantInhibition experiments
2006
Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract
Yono M, Foster HE, Weiss RM, Latifpour J. Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract. Journal Of Urology 2006, 176: 1214-1219. PMID: 16890728, DOI: 10.1016/j.juro.2006.04.038.Peer-Reviewed Original ResearchConceptsRat genitourinary tractLower urinary tract symptomsUrinary tract symptomsBenign prostatic hyperplasiaAdrenoceptor antagonistGenitourinary tractTract symptomsBladder baseProstatic hyperplasiaDorsolateral prostateYoung ratsIsolated muscle bathMaximum contractile responseTranscriptase-polymerase chain reaction techniqueRadioligand receptor bindingReverse transcriptase-polymerase chain reaction techniqueSignificant age-dependent differencesAge-dependent differencesAge related changesHigher body weightAge related differencesContractile responseAdrenoceptor densityAdrenoceptor subtypesBladder domeAge‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract
Yono M, Foster H, Yoshida M, Ueda S, Weiss R, Latifpour J. Age‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract. The FASEB Journal 2006, 20: a254-a254. DOI: 10.1096/fasebj.20.4.a254-a.Peer-Reviewed Original ResearchLower urinary tract symptomsRat genitourinary tractBenign prostatic hyperplasiaΑ1-AR antagonistsAge-related changesMonth old ratsGenitourinary tractOld ratsBladder baseBladder domeDorsolateral prostateVentral prostateUrinary tract symptomsMaximum contractile responseLow testosterone levelsRadioligand receptor bindingSignificant age-dependent differencesReal-time RT-PCR techniqueAge-dependent differencesHigher body weightRT-PCR techniqueTract symptomsContractile responseOlder patientsSubtype mRNAs
2003
Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
Afiatpour P, Latifpour J, Takahashi W, Yono M, Foster HE, Ikeda K, Pouresmail M, Weiss RM. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 2003, 367: 462-472. PMID: 12700883, DOI: 10.1007/s00210-003-0715-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyBinding SitesEndothelin-1Gene ExpressionIodine RadioisotopesMuscle ContractionMuscle, SmoothRadioligand AssayRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsUrinary BladderConceptsETA receptor subtypeSmooth muscle layerReceptor subtypesRat detrusorEndothelin receptorsET receptorsET-1Muscle layerSelective ETA receptor antagonistET receptor systemLarger contractile responsesTotal ET receptorsReceptor subtype mRNAsETA receptor antagonistETB receptor subtypesReal-time reverse transcription-polymerase chain reactionMuscle bath techniqueBladder smooth muscleReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAge-dependent decreaseAge-dependent alterationsReal-time RT-PCRContractile responseSubtype mRNAs
2001
Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis
Wada Y, Latifpour J, Saito M, Afiatpour P, Weiss R. Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis. BJU International 2001, 88: 950-959. PMID: 11851620, DOI: 10.1046/j.1464-4096.2001.2441.x.Peer-Reviewed Original ResearchConceptsRabbit renal pelvisTotal ET receptorsETA receptor subtypeRenal pelvisET receptorsET-1Age groupsContractile responseEndothelin receptorsPelvic regionReceptor subtypesSpontaneous activityET-1-induced contractile responseOld rabbitsDensities of ETAYoung rabbitsPresence of ETASubtype-selective compoundsReceptor-binding techniquesConcentration-dependent mannerETB subtypeEffect of ageETA receptorsETB receptorsMuscle strips
2000
AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. PMID: 10953160, DOI: 10.1097/00005392-200009010-00054.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile responseAGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. DOI: 10.1016/s0022-5347(05)67319-3.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile response
1997
Muscarinic Receptor Subtypes and Receptor‐Coupled Phosphatidylinositol Hydrolysis in Rat Bladder Smooth Muscle
Mimata H, Nomura Y, Emoto A, Latifpour J, Wheeler M, Weiss R. Muscarinic Receptor Subtypes and Receptor‐Coupled Phosphatidylinositol Hydrolysis in Rat Bladder Smooth Muscle. International Journal Of Urology 1997, 4: 591-596. PMID: 9477190, DOI: 10.1111/j.1442-2042.1997.tb00315.x.Peer-Reviewed Original ResearchConceptsRat bladder smooth muscleBladder smooth muscleMuscarinic receptor subtypesSmooth muscleM3 receptorsReceptor subtypesPI hydrolysisCarbachol stimulationBladder smooth muscle contractionPhosphatidylinositol hydrolysisN-methylpiperidine methiodideRat urinary bladderSubtype-specific antagonistsSmooth muscle contractionProduction of IP3Expression of mRNAContractile responseUrinary bladderSpecific antagonistMuscle contractionBasal levelsInhibitory effectSubtypesReceptorsMuscleEvidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721. PMID: 8996405, DOI: 10.1016/s0022-5347(01)65257-1.Peer-Reviewed Original ResearchConceptsCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethraEvidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721.. DOI: 10.1097/00005392-199702000-00095.Peer-Reviewed Original ResearchCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethra
1995
Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder
Mimata H, Wheeler M, Fukumoto Y, Takigawa H, Nishimoto T, Weiss R, Latifpour J. Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder. Molecular And Cellular Biochemistry 1995, 152: 71-76. PMID: 8609914, DOI: 10.1007/bf01076465.Peer-Reviewed Original ResearchConceptsDiabetic bladderRat bladderAltered functional responseControl rat bladdersCarbachol-induced increaseMuscarinic receptor densityPhosphatidyl inositol hydrolysisMuscarinic agonist stimulationSucrose-fed animalsRat detrusorContractile responseInositol phosphate productionMuscarinic receptorsMuscarinic agonistsReceptor densityBladderAgonist stimulationPhosphatidylinositol metabolismInositol uptakeEC50 valuesSignal transduction pathwaysPhosphate productionTransduction pathwaysDetrusorStreptozotocin
1991
Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes. Diabetes 1991, 40: 1150-1156. PMID: 1657672, DOI: 10.2337/diab.40.9.1150.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsSucrose-fed ratsBladder domeDetrusor stripsDiabetic ratsHigher serum glucose levelsLower serum insulin levelsLarger contractile responsesMuscarinic receptor upregulationHigher urine outputCarbachol-induced contractionDiabetes-induced alterationsMuscarinic cholinergic receptorsSerum insulin levelsSTZ-induced diabetesSerum glucose levelsIsoproterenol-induced relaxationAge-matched controlsLower body weightSucrose-fed animalsBladder hypertrophyContractile responseDiabetic bladderUrine outputRelaxed KClPharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra.
Yoshida M, Latifpour J, Nishimoto T, Weiss R. Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 1100-8. PMID: 1675287.Peer-Reviewed Original ResearchConceptsConcentration-response curvesFemale rabbit urethraContractile responseAdrenergic receptorsRabbit urethraAge groupsAlpha-2 adrenergic receptorsED50 valuesEmax valuesConcentration-dependent contractionsMaximum contractile responsePhenylephrine-induced contractionAlpha-adrenergic receptorsAlpha 1B subtypeMuscle bath techniqueYounger age groupsAge-dependent differencesPharmacological characterizationClonidinePharmacological characteristicsOxymetazolinePhenylephrineNorepinephrineFree bufferAlpha 1
1989
Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors.
Latifpour J, Gousse A, Kondo S, Morita T, Weiss R. Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 81-8. PMID: 2913290.Peer-Reviewed Original ResearchConceptsMuscarinic receptorsBladder domeDiabetic animalsMuscarinic agonistsExperimental diabetesRat bladder smooth muscleED50 valuesHigher serum glucose levelsBladder muscarinic receptorsLarger contractile responsesMuscarinic receptor propertiesAF-DX 116Serum insulin levelsSerum glucose levelsBladder smooth muscleM2 muscarinic receptorsAge-matched controlsLower body weightReceptor binding studiesBladder dysfunctionContractile responseCommon complicationDiabetes mellitusPeripheral neuropathyUrine output
1987
Sex differences in function and distribution of alpha 1- and alpha 2-adrenoceptors in rabbit urethra
Morita T, Latifpour J, O'Hollaren B, Wheeler M, Weiss R. Sex differences in function and distribution of alpha 1- and alpha 2-adrenoceptors in rabbit urethra. American Journal Of Physiology 1987, 252: f1124-f1128. PMID: 3035945, DOI: 10.1152/ajprenal.1987.252.6.f1124.Peer-Reviewed Original ResearchConceptsContractile responseFemale urethraMale urethraAlpha 1Rabbit urethraRadioligand receptor binding techniquesFemale rabbit urethraLarger contractile responsesSmall contractile responseAlpha-adrenergic agonistsUrethral smooth muscleReceptor binding techniquesReceptor binding studiesIsolated urethraSmooth muscleContractile propertiesUrethraFemale rabbitsContractile forceAgonistsInduced increasesAlpha 2Binding techniquesNorepinephrineAlphaAge-Related Changes in Contractile Force of Rabbit Detrusor Muscle to Prostaglandin E1, E2 and F2α
Morita T, Wheeler M, Weiss R. Age-Related Changes in Contractile Force of Rabbit Detrusor Muscle to Prostaglandin E1, E2 and F2α. Urologia Internationalis 1987, 42: 44-48. PMID: 3473790, DOI: 10.1159/000281848.Peer-Reviewed Original Research