2005
Regulation of cyclic nucleotides in the urinary tract
Wheeler MA, Ayyagari RR, Wheeler GL, Weiss RM. Regulation of cyclic nucleotides in the urinary tract. Journal Of Smooth Muscle Research 2005, 41: 1. PMID: 15855736, DOI: 10.1540/jsmr.41.1.Peer-Reviewed Original ResearchConceptsUrinary tractRelaxation responseLow compliance bladderSmooth muscle functionG proteinsCyclic AMP productionStimulatory G proteinCyclic nucleotide levelsG protein isoformsUrge incontinenceTreatment optionsProstate cancerMuscle functionDisease processFamily of phosphodiesterasesSpecific PDE inhibitorsAMP productionPDE inhibitorsBladderAdenylyl cyclasePDE isoformsTractPharmacological potentialCancerPDE expression
1996
Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435.. DOI: 10.1097/00005392-199604000-00098.Peer-Reviewed Original ResearchUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityFemale controlsTract infectionsGMP levelsResults Female patientsCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityAbstract PurposeDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMP