Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
Kang WS, Tamarkin FJ, Wheeler MA, Weiss RM. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation. Journal Of Pharmacology And Experimental Therapeutics 2004, 310: 452-458. PMID: 15082754, DOI: 10.1124/jpet.104.066506.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary cyclic GMPNitric oxide synthaseEscherichia coli lipopolysaccharideLPS treatmentNOS activityColi lipopolysaccharideNitric oxideEndothelial nitric oxide synthaseDependent NOS activityCyclic GMPInduction of inflammationPhosphorylation of eNOSBladder inflammationLPS injectionHuman eNOSENOS proteinIntraperitoneal injectionFemale miceBladder urotheliumInflammatory responseMolecule nitric oxideMouse modelInflammationENOS phosphorylation