1999
Induction of Nitric Oxide Synthase with Urinary Tract Infections
Wheeler M, Smith S, Weiss R. Induction of Nitric Oxide Synthase with Urinary Tract Infections. Advances In Experimental Medicine And Biology 1999, 462: 359-369. PMID: 10599439, DOI: 10.1007/978-1-4615-4737-2_28.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseOxide synthaseNitric oxideEnzyme nitric oxide synthaseUrinary tract infectionCyclic GMPNon-cholinergic neuronsGuanylyl cyclase enzymeTract infectionsL-arginineL-citrullineCyclase enzymeSecond messengerMammalian tissuesSynthaseFunctional responseNeutrophilsInfectionGMPMacrophagesNeurons
1997
Bacterial infection induces nitric oxide synthase in human neutrophils.
Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. Journal Of Clinical Investigation 1997, 99: 110-116. PMID: 9011564, PMCID: PMC507774, DOI: 10.1172/jci119121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsArginineBacterial InfectionsBlotting, WesternCanavanineCell MembraneCitrullineFemaleGuanidinesHumansImmunohistochemistryIsoenzymesLeukocyte Common AntigensMaleMiddle AgedNeutrophilsNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitroarginineOmega-N-MethylarginineOrnithinePolymerase Chain ReactionRNA, MessengerSulfonamidesThioureaTrifluoperazineUrinary Tract InfectionsConceptsInducible nitric oxide synthaseUrinary tract infectionNitric oxide synthaseNitric oxide synthase activityTract infectionsOxide synthase activityOxide synthaseInducible nitric oxide synthase activityNitric oxide synthase proteinNitric oxide synthase isoformsInduces nitric oxide synthaseMajor nitric oxide synthase isoformHuman inflammatory cellsHuman inducible nitric oxide synthaseExtended elevationInflammatory cellsProinflammatory functionsAntibiotic treatmentInflammatory processSynthase activityImmunocytochemical evidenceHuman neutrophilsInfectionCalcium independentSynthase isoforms
1994
Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine
Smith S, Wheeler M, Weiss R. Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine. Kidney International 1994, 45: 586-591. PMID: 7513034, DOI: 10.1038/ki.1994.76.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNon-infected urineTract infectionsL-arginineUrine nitriteInfected urineUrinary nitric oxide synthase activityNitric oxide synthase activityUrinary nitrite levelsEndogenous sourcesOxide synthase activitySynthase activityMin/Exogenous L-arginineNG-nitroNG-monomethylGriess methodParticulate fractionNitrite levelsUrine fractionsEndogenous productionNitrite productionUrineInfectionElevated nitrite