2004
Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
Kang WS, Tamarkin FJ, Wheeler MA, Weiss RM. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation. Journal Of Pharmacology And Experimental Therapeutics 2004, 310: 452-458. PMID: 15082754, DOI: 10.1124/jpet.104.066506.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary cyclic GMPNitric oxide synthaseEscherichia coli lipopolysaccharideLPS treatmentNOS activityColi lipopolysaccharideNitric oxideEndothelial nitric oxide synthaseDependent NOS activityCyclic GMPInduction of inflammationPhosphorylation of eNOSBladder inflammationLPS injectionHuman eNOSENOS proteinIntraperitoneal injectionFemale miceBladder urotheliumInflammatory responseMolecule nitric oxideMouse modelInflammationENOS phosphorylation
1998
Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder.
Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 1203-8. PMID: 9495884.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary tract infectionIntravesical instillationLocalized inflammatory responseInflammatory responseRat bladderSystemic bacterial lipopolysaccharideInstillation of lipopolysaccharideRat urinary bladderNitric oxide synthaseIL-6 mRNATract infectionsBladder instillationIL-10Urinary nitrateRegulate cytokinesINOS activityIntraperitoneal injectionNOS activityOxide synthaseUrinary bladderImportance of lipopolysaccharideINOS proteinInstillationCGMP levels