Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra
Wada Y, Takahashi W, Latifpour J, Yamada, Kai N, Honda J, Nakanishi J, Weiss RM. Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra. BJU International 2007, 100: 430-437. PMID: 17559559, DOI: 10.1111/j.1464-410x.2007.07064.x.Peer-Reviewed Original ResearchConceptsContractile responseET receptor subtypesMaximum contractile responseProstatic urethraReceptor subtypesET-3ET receptorsET-1High-affinity binding sitesConcentration-dependent contractile responsesSubtype specificityEndothelin receptor subtypesSmooth muscle stripsReceptor-binding techniquesRegion-specific differencesEndothelin receptorsMuscle stripsRegional differencesDistal regionUrethraSubtypesReceptorsBQ123Low affinity constantInhibition experiments