2007
Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra
Wada Y, Takahashi W, Latifpour J, Yamada, Kai N, Honda J, Nakanishi J, Weiss RM. Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra. BJU International 2007, 100: 430-437. PMID: 17559559, DOI: 10.1111/j.1464-410x.2007.07064.x.Peer-Reviewed Original ResearchConceptsContractile responseET receptor subtypesMaximum contractile responseProstatic urethraReceptor subtypesET-3ET receptorsET-1High-affinity binding sitesConcentration-dependent contractile responsesSubtype specificityEndothelin receptor subtypesSmooth muscle stripsReceptor-binding techniquesRegion-specific differencesEndothelin receptorsMuscle stripsRegional differencesDistal regionUrethraSubtypesReceptorsBQ123Low affinity constantInhibition experiments
2006
Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract
Yono M, Foster HE, Weiss RM, Latifpour J. Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract. Journal Of Urology 2006, 176: 1214-1219. PMID: 16890728, DOI: 10.1016/j.juro.2006.04.038.Peer-Reviewed Original ResearchConceptsRat genitourinary tractLower urinary tract symptomsUrinary tract symptomsBenign prostatic hyperplasiaAdrenoceptor antagonistGenitourinary tractTract symptomsBladder baseProstatic hyperplasiaDorsolateral prostateYoung ratsIsolated muscle bathMaximum contractile responseTranscriptase-polymerase chain reaction techniqueRadioligand receptor bindingReverse transcriptase-polymerase chain reaction techniqueSignificant age-dependent differencesAge-dependent differencesAge related changesHigher body weightAge related differencesContractile responseAdrenoceptor densityAdrenoceptor subtypesBladder domeAge‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract
Yono M, Foster H, Yoshida M, Ueda S, Weiss R, Latifpour J. Age‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract. The FASEB Journal 2006, 20: a254-a254. DOI: 10.1096/fasebj.20.4.a254-a.Peer-Reviewed Original ResearchLower urinary tract symptomsRat genitourinary tractBenign prostatic hyperplasiaΑ1-AR antagonistsAge-related changesMonth old ratsGenitourinary tractOld ratsBladder baseBladder domeDorsolateral prostateVentral prostateUrinary tract symptomsMaximum contractile responseLow testosterone levelsRadioligand receptor bindingSignificant age-dependent differencesReal-time RT-PCR techniqueAge-dependent differencesHigher body weightRT-PCR techniqueTract symptomsContractile responseOlder patientsSubtype mRNAs
2000
AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. PMID: 10953160, DOI: 10.1097/00005392-200009010-00054.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile responseAGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. DOI: 10.1016/s0022-5347(05)67319-3.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile response
1991
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra.
Yoshida M, Latifpour J, Nishimoto T, Weiss R. Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 1100-8. PMID: 1675287.Peer-Reviewed Original ResearchConceptsConcentration-response curvesFemale rabbit urethraContractile responseAdrenergic receptorsRabbit urethraAge groupsAlpha-2 adrenergic receptorsED50 valuesEmax valuesConcentration-dependent contractionsMaximum contractile responsePhenylephrine-induced contractionAlpha-adrenergic receptorsAlpha 1B subtypeMuscle bath techniqueYounger age groupsAge-dependent differencesPharmacological characterizationClonidinePharmacological characteristicsOxymetazolinePhenylephrineNorepinephrineFree bufferAlpha 1