1995
Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder
Mimata H, Wheeler M, Fukumoto Y, Takigawa H, Nishimoto T, Weiss R, Latifpour J. Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder. Molecular And Cellular Biochemistry 1995, 152: 71-76. PMID: 8609914, DOI: 10.1007/bf01076465.Peer-Reviewed Original ResearchConceptsDiabetic bladderRat bladderAltered functional responseControl rat bladdersCarbachol-induced increaseMuscarinic receptor densityPhosphatidyl inositol hydrolysisMuscarinic agonist stimulationSucrose-fed animalsRat detrusorContractile responseInositol phosphate productionMuscarinic receptorsMuscarinic agonistsReceptor densityBladderAgonist stimulationPhosphatidylinositol metabolismInositol uptakeEC50 valuesSignal transduction pathwaysPhosphate productionTransduction pathwaysDetrusorStreptozotocin
1993
The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate
Fukumoto Y, Yoshida M, Dokita S, Kamai T, Weiss R, Latifpour J. The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate. Journal Of Urology 1993, 149: 1602-1606. PMID: 8388963, DOI: 10.1016/s0022-5347(17)36459-5.Peer-Reviewed Original ResearchConceptsMuscarinic cholinergic receptorsBeta adrenergicRat prostateCholinergic receptorsInsulin treatmentMuscarinic receptorsInsulin-treated diabetic animalsEarly insulin treatmentDiabetes-induced alterationsInduction of diabetesInsulin-treated diabeticsOnset of diabetesAdministration of streptozotocinDiabetes-induced downregulationDiabetic rat prostateGroups of ratsBeta-adrenergic agonistsHigh-affinity agonistDiabetic animalsMuscarinic agonistsAdrenergic agonistsAdrenergicProstateDiabetesAgonists
1989
Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors.
Latifpour J, Gousse A, Kondo S, Morita T, Weiss R. Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 81-8. PMID: 2913290.Peer-Reviewed Original ResearchConceptsMuscarinic receptorsBladder domeDiabetic animalsMuscarinic agonistsExperimental diabetesRat bladder smooth muscleED50 valuesHigher serum glucose levelsBladder muscarinic receptorsLarger contractile responsesMuscarinic receptor propertiesAF-DX 116Serum insulin levelsSerum glucose levelsBladder smooth muscleM2 muscarinic receptorsAge-matched controlsLower body weightReceptor binding studiesBladder dysfunctionContractile responseCommon complicationDiabetes mellitusPeripheral neuropathyUrine output