2003
Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
Afiatpour P, Latifpour J, Takahashi W, Yono M, Foster HE, Ikeda K, Pouresmail M, Weiss RM. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 2003, 367: 462-472. PMID: 12700883, DOI: 10.1007/s00210-003-0715-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyBinding SitesEndothelin-1Gene ExpressionIodine RadioisotopesMuscle ContractionMuscle, SmoothRadioligand AssayRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsUrinary BladderConceptsETA receptor subtypeSmooth muscle layerReceptor subtypesRat detrusorEndothelin receptorsET receptorsET-1Muscle layerSelective ETA receptor antagonistET receptor systemLarger contractile responsesTotal ET receptorsReceptor subtype mRNAsETA receptor antagonistETB receptor subtypesReal-time reverse transcription-polymerase chain reactionMuscle bath techniqueBladder smooth muscleReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAge-dependent decreaseAge-dependent alterationsReal-time RT-PCRContractile responseSubtype mRNAs
1991
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra.
Yoshida M, Latifpour J, Nishimoto T, Weiss R. Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 1100-8. PMID: 1675287.Peer-Reviewed Original ResearchConceptsConcentration-response curvesFemale rabbit urethraContractile responseAdrenergic receptorsRabbit urethraAge groupsAlpha-2 adrenergic receptorsED50 valuesEmax valuesConcentration-dependent contractionsMaximum contractile responsePhenylephrine-induced contractionAlpha-adrenergic receptorsAlpha 1B subtypeMuscle bath techniqueYounger age groupsAge-dependent differencesPharmacological characterizationClonidinePharmacological characteristicsOxymetazolinePhenylephrineNorepinephrineFree bufferAlpha 1