2007
Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra
Wada Y, Takahashi W, Latifpour J, Yamada, Kai N, Honda J, Nakanishi J, Weiss RM. Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra. BJU International 2007, 100: 430-437. PMID: 17559559, DOI: 10.1111/j.1464-410x.2007.07064.x.Peer-Reviewed Original ResearchConceptsContractile responseET receptor subtypesMaximum contractile responseProstatic urethraReceptor subtypesET-3ET receptorsET-1High-affinity binding sitesConcentration-dependent contractile responsesSubtype specificityEndothelin receptor subtypesSmooth muscle stripsReceptor-binding techniquesRegion-specific differencesEndothelin receptorsMuscle stripsRegional differencesDistal regionUrethraSubtypesReceptorsBQ123Low affinity constantInhibition experiments
2001
Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis
Wada Y, Latifpour J, Saito M, Afiatpour P, Weiss R. Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis. BJU International 2001, 88: 950-959. PMID: 11851620, DOI: 10.1046/j.1464-4096.2001.2441.x.Peer-Reviewed Original ResearchConceptsRabbit renal pelvisTotal ET receptorsETA receptor subtypeRenal pelvisET receptorsET-1Age groupsContractile responseEndothelin receptorsPelvic regionReceptor subtypesSpontaneous activityET-1-induced contractile responseOld rabbitsDensities of ETAYoung rabbitsPresence of ETASubtype-selective compoundsReceptor-binding techniquesConcentration-dependent mannerETB subtypeEffect of ageETA receptorsETB receptorsMuscle strips
2000
AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. DOI: 10.1016/s0022-5347(05)67319-3.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile responseAGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. PMID: 10953160, DOI: 10.1097/00005392-200009010-00054.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile response
1995
Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705.. DOI: 10.1097/00005392-199505000-00105.Peer-Reviewed Original ResearchElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsCholera toxinMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsAge-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705. PMID: 7715014, DOI: 10.1016/s0022-5347(01)67508-6.Peer-Reviewed Original ResearchConceptsElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsBladder detrusor
1991
NG-nitro-L-arginine inhibits non-adrenergic, non-cholinergic relaxation in rabbit urethral smooth muscle
Dokita S, Morgan W, Wheeler M, Yoshida M, Latifpour J, Weiss R. NG-nitro-L-arginine inhibits non-adrenergic, non-cholinergic relaxation in rabbit urethral smooth muscle. Life Sciences 1991, 48: 2429-2436. PMID: 1675415, DOI: 10.1016/0024-3205(91)90377-n.Peer-Reviewed Original ResearchConceptsElectrical field stimulationRelaxation responseNG-nitroField stimulationL-arginineSelective cyclic GMP phosphodiesterase inhibitorNitric oxideNon-cholinergic relaxationRabbit urethral smooth muscleNon-cholinergic nervesUrethral smooth muscleUrethral smooth muscle stripsSmooth muscle stripsL-arginine inhibitsSoluble guanylate cyclaseNitric oxide biosynthesisCyclic GMP phosphodiesterase inhibitorMuscle stripsSmooth musclePhosphodiesterase inhibitorGuanylate cyclaseCyclic GMPStimulationInhibitorsResponse
1987
Age-Related Changes in Contractile Force of Rabbit Detrusor Muscle to Prostaglandin E1, E2 and F2α
Morita T, Wheeler M, Weiss R. Age-Related Changes in Contractile Force of Rabbit Detrusor Muscle to Prostaglandin E1, E2 and F2α. Urologia Internationalis 1987, 42: 44-48. PMID: 3473790, DOI: 10.1159/000281848.Peer-Reviewed Original Research
1986
Relaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP
Morita T, Wheeler M, Weiss R. Relaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP. Journal Of Urology 1986, 135: 1293-1295. PMID: 3012124, DOI: 10.1016/s0022-5347(17)46077-0.Peer-Reviewed Original ResearchConceptsDetrusor muscleRelaxant effectRabbit detrusor muscle stripsDetrusor muscle relaxationDetrusor muscle stripsRabbit detrusor muscleConcentration-dependent relaxationDetrusor smooth muscleRabbit detrusor smooth muscleBeta-adrenergic antagonistsBeta-adrenergic receptorsCyclic AMPCyclic AMP levelsAdenylate cyclase inhibitorRabbit detrusorMuscle stripsMuscle relaxationSmooth muscleCyclase inhibitorPhosphodiesterase inhibitorRelaxation responseAMP levelsAdenylate cyclaseDependent relaxationForskolinCharacterization of Functional Beta-Adrenoceptor Subtypes in Rabbit Urinary Bladder Smooth Muscle
MORITA T, KONDO S, TSUCHIDA S, WEISS R. Characterization of Functional Beta-Adrenoceptor Subtypes in Rabbit Urinary Bladder Smooth Muscle. The Tohoku Journal Of Experimental Medicine 1986, 149: 389. PMID: 3022421, DOI: 10.1620/tjem.149.389.Peer-Reviewed Original ResearchConceptsTrigonal muscleRelaxant responsesM isoproterenolRabbit urinary bladder smooth muscleUrinary bladder smooth muscleSignificant relaxant responseSpontaneous contractile forceUrinary bladder domeBeta-adrenoceptor subtypesBeta-adrenoceptor agonistsBeta-adrenoceptor stimulationMaximum relaxant responseBladder smooth muscleM butoxamineM metoprololSelective betaBladder domeMuscle stripsM propranololSpecific betaDetrusorSmooth muscleMale rabbitsIsoproterenolContractile force