1994
Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation
Dokita S, Smith S, Nishimoto T, Wheeler M, Weiss R. Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation. European Journal Of Pharmacology 1994, 266: 269-275. PMID: 7513645, DOI: 10.1016/0922-4106(94)90136-8.Peer-Reviewed Original ResearchConceptsNitric oxide synthase activityTransmural nerve stimulationOxide synthase activityRabbit urethraNerve stimulationNOS activityL-arginineSoluble nitric oxide synthaseNitric oxide synthase inhibitorRelaxation responseNitric oxideCyclic GMPOxide synthase inhibitorNitric oxide synthaseCyclic GMP levelsUrethral relaxationNG-nitroRank orderOxide synthaseSynthase activityNG-methylSynthase inhibitorElectrical stimulationUrethraSame rank orderNitric oxide synthase: An endogenous source of elevated nitrite in infected urine
Smith S, Wheeler M, Weiss R. Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine. Kidney International 1994, 45: 586-591. PMID: 7513034, DOI: 10.1038/ki.1994.76.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNon-infected urineTract infectionsL-arginineUrine nitriteInfected urineUrinary nitric oxide synthase activityNitric oxide synthase activityUrinary nitrite levelsEndogenous sourcesOxide synthase activitySynthase activityMin/Exogenous L-arginineNG-nitroNG-monomethylGriess methodParticulate fractionNitrite levelsUrine fractionsEndogenous productionNitrite productionUrineInfectionElevated nitrite
1991
NG-nitro-L-arginine inhibits non-adrenergic, non-cholinergic relaxation in rabbit urethral smooth muscle
Dokita S, Morgan W, Wheeler M, Yoshida M, Latifpour J, Weiss R. NG-nitro-L-arginine inhibits non-adrenergic, non-cholinergic relaxation in rabbit urethral smooth muscle. Life Sciences 1991, 48: 2429-2436. PMID: 1675415, DOI: 10.1016/0024-3205(91)90377-n.Peer-Reviewed Original ResearchConceptsElectrical field stimulationRelaxation responseNG-nitroField stimulationL-arginineSelective cyclic GMP phosphodiesterase inhibitorNitric oxideNon-cholinergic relaxationRabbit urethral smooth muscleNon-cholinergic nervesUrethral smooth muscleUrethral smooth muscle stripsSmooth muscle stripsL-arginine inhibitsSoluble guanylate cyclaseNitric oxide biosynthesisCyclic GMP phosphodiesterase inhibitorMuscle stripsSmooth musclePhosphodiesterase inhibitorGuanylate cyclaseCyclic GMPStimulationInhibitorsResponse