2013
Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer
Martin DT, Hoimes CJ, Kaimakliotis HZ, Cheng CJ, Zhang K, Liu J, Wheeler MA, Kelly WK, Tew GN, Saltzman WM, Weiss RM. Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. Nanomedicine Nanotechnology Biology And Medicine 2013, 9: 1124-1134. PMID: 23764660, PMCID: PMC3815967, DOI: 10.1016/j.nano.2013.05.017.Peer-Reviewed Original ResearchConceptsHistone deacetylase inhibitor belinostatBladder cancerBladder permeability barrierNon-invasive bladder cancerCultured bladder cancer cellsBladder cancer cellsChemotherapy efficacyIntravesical drug deliveryXenograft tumorsMouse bladderMouse modelConvincing dataHuman ureterBelinostatCancerCancer cellsLower IC50TumorsAcetyl-H4Tissue penetrationCLINICAL EDITORIntracellular uptakeDeliveryCellsPatients
2008
Initial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele
Reiner E, Pollak JS, Henderson KJ, Weiss RM, White RI. Initial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele. Journal Of Vascular And Interventional Radiology 2008, 19: 207-210. PMID: 18341950, DOI: 10.1016/j.jvir.2007.08.013.Peer-Reviewed Original ResearchConceptsInternal spermatic veinSodium tetradecyl sulfate foamSTS foamAdolescent patientsPampiniform plexusSI jointLeft internal spermatic veinRight femoral veinResults of treatmentSurgical recurrenceScrotal discomfortTesticular atrophyCollateral vesselsPhysical examinationFemoral veinSpermatic veinSacroiliac jointAdolescent varicoceleFibered coilsPatientsInitial experienceVaricoceleAdolescent subjectsDeliberate passagePlexus
2005
CLINICAL AND HISTOLOGICAL SIGNIFICANCE OF THE TESTICULAR REMNANT FOUND ON INGUINAL EXPLORATION AFTER DIAGNOSTIC LAPAROSCOPY IN THE ABSENCE OF A PATENT PROCESSUS VAGINALIS
RENZULLI JF, SHETTY R, MANGRAY S, ANDERSON KR, WEISS RM, CALDAMONE AA. CLINICAL AND HISTOLOGICAL SIGNIFICANCE OF THE TESTICULAR REMNANT FOUND ON INGUINAL EXPLORATION AFTER DIAGNOSTIC LAPAROSCOPY IN THE ABSENCE OF A PATENT PROCESSUS VAGINALIS. Journal Of Urology 2005, 174: 1584-1586. PMID: 16148657, DOI: 10.1097/01.ju.0000179541.92934.17.Peer-Reviewed Original ResearchConceptsGerm cell elementsPatent processus vaginalisInternal inguinal ringProcessus vaginalisClosed processus vaginalisInguinal explorationTesticular remnantsNonpalpable testisHistological findingsInguinal ringSpermatic vesselsClosed internal inguinal ringVas deferensClosed internal ringPresence of hemosiderinCell elementsDiagnostic laparoscopyLaparoscopic explorationRetrospective reviewHistological significancePatientsLeft sideCord structuresRight sideIncidence
2000
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients
Smith S, Wheeler M, Lorber M, Weiss R. Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients. Kidney International 2000, 58: 829-837. PMID: 10916108, DOI: 10.1046/j.1523-1755.2000.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultCreatinineCyclic GMPCytokinesFemaleFollow-Up StudiesGraft RejectionHumansInterleukin-10Interleukin-2Interleukin-6Interleukin-8Kidney Failure, ChronicKidney TransplantationMaleMiddle AgedNitratesNitric OxideNitritesPredictive Value of TestsTime FactorsTumor Necrosis Factor-alphaUrinary Tract InfectionsConceptsUrinary tract infectionRenal transplant patientsAcute rejectionTransplant patientsCyclic GMPIL-2Nitric oxideNitric oxide synthase activityAdditional urine specimensUrine cytokine levelsUrine nitrate levelsNitric oxide productsMonths of transplantationOxide synthase activityUrine nitrateSoluble interleukinCytokine levelsTract infectionsIL-10IL-6IL-8Tumor necrosisUrine specimensPatientsClinical diagnosis
1999
A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
KORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Journal Of Urology 1999, 161: 558-565. PMID: 9915448, DOI: 10.1016/s0022-5347(01)61950-5.Peer-Reviewed Original ResearchConceptsL-arginine groupOral L-arginineNitric oxide synthase activityInterstitial cystitis symptomsInterstitial cystitis patientsOxide synthase activityPlacebo groupInterstitial cystitisL-arginineCystitis symptomsCystitis patientsUrinary nitric oxide synthase activityRandomized double-blind trialDouble-blind trialFrequency of painL-arginine treatmentGreater global improvementNitric oxide synthaseUrine of patientsUrine of controlsPain intensityOxide synthaseSynthase activityGlobal improvementPatientsA RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
KORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Journal Of Urology 1999, 161: 558-565.. DOI: 10.1097/00005392-199902000-00055.Peer-Reviewed Original ResearchL-arginine groupOral L-arginineNitric oxide synthase activityInterstitial cystitis symptomsInterstitial cystitis patientsOxide synthase activityPlacebo groupInterstitial cystitisL-arginineCystitis symptomsCystitis patientsUrinary nitric oxide synthase activityRandomized double-blind trialDouble-blind trialFrequency of painL-arginine treatmentGreater global improvementNitric oxide synthaseUrine of patientsUrine of controlsPain intensityOxide synthaseSynthase activityGlobal improvementPatients
1997
Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine
Smith S, Wheeler M, Foster H, Weiss R. Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine. Journal Of Urology 1997, 158: 703-708. DOI: 10.1016/s0022-5347(01)64297-6.Peer-Reviewed Original ResearchConceptsOral L-arginineL-arginineInterstitial cystitisInterstitial Cystitis Symptom ScoreNitric oxide synthase activityLower abdominal painInterstitial cystitis symptomsL-arginine treatmentOxide synthase activityNitric oxide synthaseSelf-controlled studyAbdominal painUrethral painUrinary frequencyCystitis symptomsSymptom scoresMethodsTen patientsOxide synthaseRelated symptomsImmunological responseNitric oxidePatientsSymptomsSignificant decreaseCystitisImprovement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine
Smith S, Wheeler M, Foster H, Weiss R. Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine. Journal Of Urology 1997, 158: 703-708.. PMID: 9258064, DOI: 10.1097/00005392-199709000-00005.Peer-Reviewed Original ResearchConceptsOral L-arginineL-arginineInterstitial cystitisUrinary nitric oxide synthase activityInterstitial Cystitis Symptom ScoreOral L-arginine treatmentNitric oxide synthase activityLower abdominal painInterstitial cystitis symptomsMethods Ten patientsL-arginine treatmentOxide synthase activityNitric oxide synthaseSelf-controlled studyAbdominal painTEN patientsUrethral painUrinary frequencyCystitis symptomsSymptom scoresOxide synthaseRelated symptomsImmunological responseNitric oxidePatients
1996
Nitric oxide synthase induction with renal transplant rejection or infection
Smith S, Wheeler M, Zhang R, Weiss E, Lorber M, Sessa W, Weiss R. Nitric oxide synthase induction with renal transplant rejection or infection. Kidney International 1996, 50: 2088-2093. PMID: 8943494, DOI: 10.1038/ki.1996.533.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRenal transplant patientsNitric oxide synthaseCyclic GMP levelsTransplant patientsTract infectionsNOS activityPost-renal transplantation patientsGMP levelsInducible nitric oxide synthaseNitric oxideRenal allograft rejectionRenal transplant rejectionNitric oxide synthase inductionInducible NOS (iNOS) mRNAUrine of patientsRenal transplantationTransplantation patientsAllograft rejectionTransplant rejectionInducible NOSOxide synthaseNOS mRNAPatientsSynthase inductionUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMPUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435.. DOI: 10.1097/00005392-199604000-00098.Peer-Reviewed Original ResearchUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityFemale controlsTract infectionsGMP levelsResults Female patientsCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityAbstract PurposeDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclase
1987
Preliminary Results with Aminophylline as Smooth-Muscle Relaxant in Percutaneous Renal Surgery
GREEN D, GLICKMAN M, WEISS R. Preliminary Results with Aminophylline as Smooth-Muscle Relaxant in Percutaneous Renal Surgery. Journal Of Endourology 1987, 1: 243-247. DOI: 10.1089/end.1987.1.243.Peer-Reviewed Case Reports and Technical NotesUreteropelvic junctionUpper urinary tractSmooth muscle relaxantSmooth muscle relaxationPercutaneous renal surgeryInfundibular spasmUrinary tractRenal surgeryRenal stonesSmooth muscleCaliceal stonesSpasmPhosphodiesterase inhibitorPatientsAminophyllineStrictureStonesRelaxantsSurgeryPyeloplastyScarringEndopyelotomyTractOcclusion
1982
Venography of the Undescended Testis
Weiss R, Glickman M. Venography of the Undescended Testis. Urologic Clinics Of North America 1982, 9: 387-395. PMID: 6128822, DOI: 10.1016/s0094-0143(21)01353-7.Peer-Reviewed Original Research
1981
Urinary undiversion in patients with myelodysplasia and neurogenic bladder dysfunction Report of a Workshop
Borden T, McGuire E, Woodside J, Allen T, Bauer S, Firlit C, Gonzales E, Kaplan W, King L, Klauber G, Perlmutter A, Thornbury J, Weiss R. Urinary undiversion in patients with myelodysplasia and neurogenic bladder dysfunction Report of a Workshop. Urology 1981, 18: 223-228. PMID: 7025417, DOI: 10.1016/0090-4295(81)90349-6.Peer-Reviewed Original ResearchConceptsUrinary undiversionReasonable surgical treatmentSuch reconstructive surgeryNeurogenic bladder dysfunctionBladder dysfunctionNeurogenic bladderAbsolute contraindicationSelect patientsMyelodysplastic patientsSurgical treatmentUrinary diversionReconstructive surgeryUndiversionPatientsRole of reconstructionContraindicationsBladderReportMyelodysplasiaSurgeryDysfunctionEvaluation
1979
Clinical Implications of Gonadal Venography in the Management of the Non-Palpable Undescended Testis
Weiss R, Glickman M, Lytton B. Clinical Implications of Gonadal Venography in the Management of the Non-Palpable Undescended Testis. Journal Of Urology 1979, 121: 745-749. PMID: 37348, DOI: 10.1016/s0022-5347(17)56977-3.Peer-Reviewed Original Research
1976
Urologic Complications of Inflammatory Bowel Disease
Shield D, Lytton B, Weiss R, Schiff M. Urologic Complications of Inflammatory Bowel Disease. Journal Of Urology 1976, 115: 701-706. PMID: 940206, DOI: 10.1016/s0022-5347(17)59341-6.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBowel diseaseUrologic complicationsPrimary bowel diseaseUrinary tract complicationsLong-term managementEnterovesical fistulaUrologic evaluationGastrointestinal disordersUreteral obstructionComplicationsDiseaseUrinary calculiPatientsCommon problemFistulaObstructionSymptomsManagement of Urinary Fistulas after Renal Transplantation
Schiff M, Mcguire E, Weiss R, Lytton B. Management of Urinary Fistulas after Renal Transplantation. Journal Of Urology 1976, 115: 251-256. PMID: 768526, DOI: 10.1016/s0022-5347(17)59160-0.Peer-Reviewed Original ResearchTreatment of Autonomic Dysreflexia with Phenoxybenz Amine
Mcguire E, Wagner F, Weiss R. Treatment of Autonomic Dysreflexia with Phenoxybenz Amine. Journal Of Urology 1976, 115: 53-55. PMID: 1246113, DOI: 10.1016/s0022-5347(17)59065-5.Peer-Reviewed Original Research
1975
Secondary bladder neck obstruction in patients with urethral valves Treatment with phenoxybenzamine
McGuire E, Weiss R. Secondary bladder neck obstruction in patients with urethral valves Treatment with phenoxybenzamine. Urology 1975, 5: 756-758. PMID: 1136085, DOI: 10.1016/0090-4295(75)90347-7.Peer-Reviewed Original ResearchConceptsBladder neck obstructionNeck obstructionSecondary bladder neck obstructionAlpha-adrenergic blocking agentAdministration of phenoxybenzamineBladder neck revisionTreatment of patientsValve fulgurationValve treatmentUrethral resistanceBlocking agentPatientsObstructionPhenoxybenzamineReversible methodTreatmentHarmful effectsFulgurationAgentsAdministrationPalliative Urinary Diversion for Pelvic Malignancy
Brin E, Schiff M, Weiss R. Palliative Urinary Diversion for Pelvic Malignancy. Journal Of Urology 1975, 113: 619-622. PMID: 47918, DOI: 10.1016/s0022-5347(17)59536-1.Peer-Reviewed Original Research