2000
Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
Saito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.Peer-Reviewed Original ResearchConceptsRat bladder domeEndothelin receptorsBladder domeInsulin treatmentReceptor subtypesFunctional endothelin receptorsMammalian urinary tractEndothelin receptor subtypesInduction of diabetesAge-matched controlsReceptor alterationsExperimental diabetesUrinary tractPharmacological characterizationPharmacological profileMuscular layerMRNA upregulationAutoradiographic studyTranscription-polymerase chain reaction dataReceptorsExpression levelsDiabetesTissue componentsSubtypesTreatment
1994
Reversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors
Fukomoto Y, Yoshida M, Weiss R, Latifpour J. Reversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors. Diabetes 1994, 43: 819-826. PMID: 8194669, DOI: 10.2337/diab.43.6.819.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBody WeightCell MembraneDiabetes Mellitus, ExperimentalDiaminesDiuresisDrinking BehaviorInsulinKineticsMaleMyocardiumOrgan SizeParasympatholyticsPiperidinesPirenzepineProstateQuinuclidinyl BenzilateRatsRats, Sprague-DawleyReceptors, MuscarinicSucroseTestosteroneUp-RegulationUrinary BladderConceptsAge-matched control ratsMuscarinic receptorsRat bladder domeBladder domeDiuretic ratsDiabetic ratsControl ratsSTZ-induced diabetic ratsInsulin-treated diabetic ratsDiabetes-induced upregulationEarly insulin treatmentSucrose-fed ratsGroups of ratsIncreased water intakeBladder hypertrophyUrine outputInsulin treatmentRadioligand receptorRatsDiabetesDiuretic stateReceptorsWater intakeWeeksUpregulation