2003
Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
Afiatpour P, Latifpour J, Takahashi W, Yono M, Foster HE, Ikeda K, Pouresmail M, Weiss RM. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 2003, 367: 462-472. PMID: 12700883, DOI: 10.1007/s00210-003-0715-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyBinding SitesEndothelin-1Gene ExpressionIodine RadioisotopesMuscle ContractionMuscle, SmoothRadioligand AssayRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsUrinary BladderConceptsETA receptor subtypeSmooth muscle layerReceptor subtypesRat detrusorEndothelin receptorsET receptorsET-1Muscle layerSelective ETA receptor antagonistET receptor systemLarger contractile responsesTotal ET receptorsReceptor subtype mRNAsETA receptor antagonistETB receptor subtypesReal-time reverse transcription-polymerase chain reactionMuscle bath techniqueBladder smooth muscleReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAge-dependent decreaseAge-dependent alterationsReal-time RT-PCRContractile responseSubtype mRNAs
1995
Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder
Mimata H, Wheeler M, Fukumoto Y, Takigawa H, Nishimoto T, Weiss R, Latifpour J. Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder. Molecular And Cellular Biochemistry 1995, 152: 71-76. PMID: 8609914, DOI: 10.1007/bf01076465.Peer-Reviewed Original ResearchConceptsDiabetic bladderRat bladderAltered functional responseControl rat bladdersCarbachol-induced increaseMuscarinic receptor densityPhosphatidyl inositol hydrolysisMuscarinic agonist stimulationSucrose-fed animalsRat detrusorContractile responseInositol phosphate productionMuscarinic receptorsMuscarinic agonistsReceptor densityBladderAgonist stimulationPhosphatidylinositol metabolismInositol uptakeEC50 valuesSignal transduction pathwaysPhosphate productionTransduction pathwaysDetrusorStreptozotocinAge-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705. PMID: 7715014, DOI: 10.1016/s0022-5347(01)67508-6.Peer-Reviewed Original ResearchConceptsElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsBladder detrusorAge-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705.. DOI: 10.1097/00005392-199505000-00105.Peer-Reviewed Original ResearchElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsCholera toxinMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractions