2005
Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes
Yono M, Pouresmail M, Takahashi W, Flanagan JF, Weiss RM, Latifpour J. Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes. Naunyn-Schmiedeberg's Archives Of Pharmacology 2005, 372: 251-255. PMID: 16235050, DOI: 10.1007/s00210-005-0010-9.Peer-Reviewed Original ResearchConceptsSTZ-induced diabetesBB ratsSpontaneous diabetesGenitourinary tractInsulin treatmentDiabetes-resistant BB ratsDiabetes-prone BB ratsHyperglycemic diabetic ratsStreptozotocin-induced diabetesSerum testosterone levelsSignificant decreaseGroups of ratsEuglycemic diabeticsEuglycemic groupTissue weight changesBladder weightDiabetic ratsSuboptimal doseAdrenal glandHyperglycemic groupDiabetic studyTestosterone levelsDiabetesControl groupVentral prostate
1998
Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes
Nishi K, Wada Y, Saito M, Foster H, Weiss R, Latifpour J. Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes. Urologia Internationalis 1998, 61: 147-153. PMID: 9933834, DOI: 10.1159/000030311.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AntagonistsAnalysis of VarianceAnimalsBinding SitesCulture TechniquesDiabetes Mellitus, ExperimentalDisease Models, AnimalDown-RegulationLinear ModelsMaleProstateRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReference ValuesSpleenStreptozocinSubmandibular GlandVas DeferensConceptsRat prostateAlpha-1 adrenergic receptorsInduction of diabetesSTZ-induced diabetesWeeks of streptozotocinDiabetic rat prostateSimilar pharmacological profileReceptor subtype specificityExperimental diabetesAlpha1A-subtypeRat submaxillary glandReceptor-binding experimentsRat vasPharmacological profileDiabetesProstateSubtype specificityPharmacological propertiesKi valuesSubmaxillary glandRat spleenPrazosinWB4101BMY7378Spiperone
1991
Muscarinic receptors in diabetic rat prostate
Latifpour J, Gousse A, Yoshida M, Weiss R. Muscarinic receptors in diabetic rat prostate. Biochemical Pharmacology 1991, 42: s113-s119. PMID: 1768268, DOI: 10.1016/0006-2952(91)90400-y.Peer-Reviewed Original ResearchConceptsMuscarinic receptorsRat prostateM3 muscarinic receptor subtypesMembrane particulatesAF-DX 116Injection of streptozotocinMuscarinic cholinergic receptorsMuscarinic receptor subtypesSTZ-induced diabetesM3 muscarinic receptorsDiabetic rat prostateLower body weightGroups of ratsInsulin-treated animalsVariety of abnormalitiesDiabetic insulinMuscarinic antagonistSmaller prostatesCholinergic receptorsReceptor subtypesPharmacological profileBody weightFmol/Myo-inositolDiabetesDifferential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes. Diabetes 1991, 40: 1150-1156. PMID: 1657672, DOI: 10.2337/diab.40.9.1150.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsSucrose-fed ratsBladder domeDetrusor stripsDiabetic ratsHigher serum glucose levelsLower serum insulin levelsLarger contractile responsesMuscarinic receptor upregulationHigher urine outputCarbachol-induced contractionDiabetes-induced alterationsMuscarinic cholinergic receptorsSerum insulin levelsSTZ-induced diabetesSerum glucose levelsIsoproterenol-induced relaxationAge-matched controlsLower body weightSucrose-fed animalsBladder hypertrophyContractile responseDiabetic bladderUrine outputRelaxed KCl