2013
A novel polymer-coated nanoparticle (NP) for urothelium penetration and drug delivery.
Hoimes C, Martin D, Kaimakliotis H, Cheng C, Kelly W, Tew G, Wheeler M, Weiss R, Saltzman W. A novel polymer-coated nanoparticle (NP) for urothelium penetration and drug delivery. Journal Of Clinical Oncology 2013, 31: e15543-e15543. DOI: 10.1200/jco.2013.31.15_suppl.e15543.Peer-Reviewed Original ResearchBladder cancerUM-UC-3Human ureterProgression of BCNon-invasive bladder cancerInhibition of invasionHDAC inhibitor belinostatFlank xenograftsTumor sizeDisease progressionTumor regressionUrothelial barrierTumor volumeIntravesical drug deliveryMouse bladderBC cellsHDAC inhibitionMurine bladderCell cytotoxicityT24 lineFACS analysisSimilar IC50Three daysFinal treatmentUreterBrg1 Determines Urothelial Cell Fate during Ureter Development
Weiss RM, Guo S, Shan A, Shi H, Romano RA, Sinha S, Cantley LG, Guo JK. Brg1 Determines Urothelial Cell Fate during Ureter Development. Journal Of The American Society Of Nephrology 2013, 24: 618-626. PMID: 23449535, PMCID: PMC3609140, DOI: 10.1681/asn.2012090902.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsUreter developmentBasal cell populationUreteral smooth muscle cellsHoxb7-CreTerminal differentiationPPARγ expressionUreteral epitheliumMuscle cellsUrothelial cellsP63 expressionRole of BRG1Basal cellsUmbrella cellsCell populationsSonic hedgehog expressionEpithelial stratificationAdult ureterUreterCell developmentBRG1 expressionSmooth muscle cell developmentShh expressionCellsHedgehog expression
1999
Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter
Saito M, Weiss R, Latifpour J. Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter. International Journal Of Urology 1999, 6: 361-368. PMID: 10445306, DOI: 10.1046/j.1442-2042.1999.00074.x.Peer-Reviewed Original Research
1997
Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle
Wheeler M, Pontari M, Dokita S, Nishimoto T, Cho Y, Hong K, Weiss R. Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle. Molecular And Cellular Biochemistry 1997, 169: 115-124. PMID: 9089638, DOI: 10.1023/a:1006823611864.Peer-Reviewed Original ResearchConceptsSoluble guanylyl cyclase activityAdult guinea pigsGuanylyl cyclase activityCyclase activityBladder domeSodium nitroprussideGuinea pigsUrinary tract smooth muscleGuanylyl cyclaseAtrial natriuretic factorParticulate guanylyl cyclaseAge-dependent changesAge-specific differencesUrinary tractNatriuretic factorSmooth muscleUreterUrethraRelaxation responseBladderInduced activationNitroprussideTissueRank orderAgeExperimental Diabetes Upregulates the Expression of Uretereral Endothelin Receptors
Nakamura I, Saito M, Fukumoto Y, Yoshida M, Nishi K, Weiss R, Latifpour J. Experimental Diabetes Upregulates the Expression of Uretereral Endothelin Receptors. Peptides 1997, 18: 1091-1093. PMID: 9357071, DOI: 10.1016/s0196-9781(97)00026-0.Peer-Reviewed Original Research
1995
Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract
Wheeler M, Martin T, Weiss R. Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract. Journal Of Urology 1995, 153: 2044-2049. PMID: 7752391, DOI: 10.1016/s0022-5347(01)67399-3.Peer-Reviewed Original ResearchConceptsPhosphatidyl inositol hydrolysisPI hydrolysisCyclic AMP levelsCAMP levelsBladder domeAMP levelsUrinary tract functionEffect of carbacholGuinea-pig ureterAgonist-induced changesBasal cAMP levelsUrinary tractMuscarinic cholinergicTract functionSecond messenger systemsCarbacholNorepinephrinePig ureterSustained increaseUreterUrethraSecond messenger levelsMessenger systemsForskolinTransitory increaseEffect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract
Wheeler M, Martin T, Weiss R. Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract. Journal Of Urology 1995, 153: 2044-2049.. DOI: 10.1097/00005392-199506000-00100.Peer-Reviewed Original ResearchPhosphatidyl inositol hydrolysisPI hydrolysisCyclic AMP levelsCAMP levelsBladder domeAMP levelsUrinary tract functionEffect of carbacholGuinea-pig ureterAgonist-induced changesBasal cAMP levelsUrinary tractMuscarinic cholinergicSecond messenger systemsTract functionCarbacholNorepinephrinePig ureterSustained increaseUreterUrethraSecond messenger levelsMessenger systemsForskolinMessenger levels
1987
Complications of Ureteral Endoscopy
Lytton B, Weiss R, Green D. Complications of Ureteral Endoscopy. Journal Of Urology 1987, 137: 649-653. PMID: 3550147, DOI: 10.1016/s0022-5347(17)44165-6.Peer-Reviewed Original ResearchConceptsUreteral perforationUpper ureteral stonesVariety of indicationsIleal replacementMinor complicationsMajor complicationsUreteral lesionsUrinary extravasationAseptic necrosisSurgical correctionIntramural ureterUreteral endoscopyUreteral stonesBasket extractionUreteral calculiComplicationsUreteroscopic proceduresUreterPerforationRigid ureterorenoscopeIleusMorbidityUrinomaPainMarsupializationUreteral Urine Transport: Changes in Bolus Volume, Peristaltic Frequency, Intraluminal Pressure and Volume of Flow Resulting from Autonomic Drugs
Morita T, Wada I, Saeki H, Tsuchida S, Weiss R. Ureteral Urine Transport: Changes in Bolus Volume, Peristaltic Frequency, Intraluminal Pressure and Volume of Flow Resulting from Autonomic Drugs. Journal Of Urology 1987, 137: 132-135. PMID: 3795356, DOI: 10.1016/s0022-5347(17)43904-8.Peer-Reviewed Original ResearchConceptsUreteral peristaltic frequencyPeristaltic frequencyContractile pressureBolus volumeIntraluminal pressureAutonomic nervous systemAutonomic agonistsAutonomic drugsNervous systemBaseline pressureExperimental modelSmall decreaseUrine transportBaselineResultant decreaseBolus formationFlow volumeElevationFluid transportNorepinephrineAcetylcholineDecreaseUreterAgonistsIsoproterenol
1986
The Role of Ureteral Peristaltic Rate and Bolus Volume on Increasing Urine Flow
Saeki H, Morita T, Weiss R, Miyagawa I. The Role of Ureteral Peristaltic Rate and Bolus Volume on Increasing Urine Flow. Urologia Internationalis 1986, 41: 174-179. PMID: 3750577, DOI: 10.1159/000281192.Peer-Reviewed Original ResearchConceptsUreteral peristaltic ratePeristaltic rateUrine flowBolus volumeTransport of urineUrodynamic parametersMongrel dogsAcute diuresisUreteral peristalsisUrine increasesUrine secretionUreterElectromyogramRate alterationsFlow increasesOliguriaPolyuriaDiuresisConsequent increaseFurosemidePeristalsisSecretionDogsUrine
1985
"On" and "off" responses of guinea pig ureter
Hong K, Biancani P, Weiss R. "On" and "off" responses of guinea pig ureter. American Journal Of Physiology 1985, 248: c165-c169. PMID: 3917613, DOI: 10.1152/ajpcell.1985.248.1.c165.Peer-Reviewed Original Research
1982
Rationale for ureteral tapering
Weiss R, Biancani P. Rationale for ureteral tapering. Urology 1982, 20: 482-487. PMID: 7147526, DOI: 10.1016/0090-4295(82)90118-2.Peer-Reviewed Original ResearchConceptsUreteral taperingIntraluminal pressureContractile forceMuscle hypertrophyIntraluminal pressure wavesWeeks of obstructionLow intraluminal pressureUrine transportIntrarenal hemodynamicsUreteral dilatationParadoxical decreaseUreteral wallHypertrophyLaplace relationshipTaperingUreterHemodynamicsDilatationObstructionContractilityEffect of obstruction on ureteral circumferential force-length relations
Biancani P, Hausman M, Weiss R. Effect of obstruction on ureteral circumferential force-length relations. American Journal Of Physiology 1982, 243: f204-f210. PMID: 7114220, DOI: 10.1152/ajprenal.1982.243.2.f204.Peer-Reviewed Original ResearchConceptsMuscle hypertrophyIntraluminal pressureCross-sectional muscle areaControl uretersPeak active forceUreteral diameterUreteral segmentActive circumferential stressObstructionUreterObstructed uretersContractile forceHypertrophyContractilityMuscle areaContractility resultsEffects of obstructionForce-length relationLaplace relationshipWkCorresponding doubling
1978
Ureteral function
Weiss R. Ureteral function. Urology 1978, 12: 114-133. PMID: 211688, DOI: 10.1016/0090-4295(78)90321-7.Peer-Reviewed Original ResearchConceptsUreteral functionBeta-adrenergic receptor mechanismVesico-ureteral refluxElectrical activitySmooth muscle relaxationUreteral peristaltic activityBeta-adrenergic receptorsUrinary collecting systemExcitation-contraction couplingAge-dependent factorsUreteral contractionsUreteral lengthUreteral activityIntracellular storage sitesMuscle relaxationReceptor mechanismsPeristaltic activityAction potentialsUreterPacemaker siteProximal portionCollecting systemContractile proteinsCell membraneContractile process
1976
Management of Urinary Fistulas after Renal Transplantation
Schiff M, Mcguire E, Weiss R, Lytton B. Management of Urinary Fistulas after Renal Transplantation. Journal Of Urology 1976, 115: 251-256. PMID: 768526, DOI: 10.1016/s0022-5347(17)59160-0.Peer-Reviewed Original Research