2007
Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra
Wada Y, Takahashi W, Latifpour J, Yamada, Kai N, Honda J, Nakanishi J, Weiss RM. Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra. BJU International 2007, 100: 430-437. PMID: 17559559, DOI: 10.1111/j.1464-410x.2007.07064.x.Peer-Reviewed Original ResearchConceptsContractile responseET receptor subtypesMaximum contractile responseProstatic urethraReceptor subtypesET-3ET receptorsET-1High-affinity binding sitesConcentration-dependent contractile responsesSubtype specificityEndothelin receptor subtypesSmooth muscle stripsReceptor-binding techniquesRegion-specific differencesEndothelin receptorsMuscle stripsRegional differencesDistal regionUrethraSubtypesReceptorsBQ123Low affinity constantInhibition experiments
1999
Developmental aspects of endothelin receptors in rabbit lower urinary tract
Saito M, Latifpour J, Weiss R. Developmental aspects of endothelin receptors in rabbit lower urinary tract. Neurourology And Urodynamics 1999, 19: 71-85. PMID: 10602249, DOI: 10.1002/(sici)1520-6777(2000)19:1<71::aid-nau8>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsLower urinary tractRabbit lower urinary tractEndothelin receptorsUrinary tractBladder baseBladder domeMale rabbitsEndothelin receptor subtypesAge-related alterationsOld male rabbitsET receptorsReceptor subtypesPharmacological characterizationPharmacological profileAged rabbitsSubtype specificityReceptorsTractDevelopment-related changesSimilar proportionsWeeksReceptor compoundsUrethraRabbitsRank order
1998
CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA
NISHI K, LATIFPOUR J, SAITO M, FOSTER H, YOSHIDA M, WEISS R. CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA. Journal Of Urology 1998, 160: 196-205. PMID: 9628650, DOI: 10.1016/s0022-5347(01)63090-8.Peer-Reviewed Original ResearchConceptsAlpha1 adrenoceptorsRabbit urethraMale rabbit urethraSelective alpha1-adrenoceptor antagonistAnti-alpha smooth muscle actinAlpha1-adrenoceptor antagonistRabbit urethral smooth muscleUrethral smooth muscleRadioligand receptor bindingSmooth muscle actinSmooth muscle fibersLight microscopic autoradiographySingle high-affinity binding siteAdrenoceptor antagonistBMY 7378Distal urethraWB 4101Immunohistochemical studyPharmacological characterizationSmooth musclePharmacological profileAdrenoceptorsUrethraMuscle actinHigh-affinity binding sitesCHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA
NISHI K, LATIFPOUR J, SAITO M, FOSTER H, YOSHIDA M, WEISS R. CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA. Journal Of Urology 1998, 160: 196-205.. DOI: 10.1097/00005392-199807000-00084.Peer-Reviewed Original ResearchAlpha1 adrenoceptorsMale rabbit urethraRabbit urethraSelective alpha1-adrenoceptor antagonistAnti-alpha smooth muscle actinAlpha1-adrenoceptor antagonistRadioligand receptor bindingSmooth muscle actinLight microscopic autoradiographySingle high-affinity binding siteAdrenoceptor antagonistPharmacological profileAbstract PurposeMuscle actinHigh-affinity binding sitesUrethraSubtype specificityAdrenoceptorsAffinity binding sitesReceptor bindingActin antibodyMicroscopic autoradiographySaturation experimentsInhibition experimentsRank order
1997
Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle
Wheeler M, Pontari M, Dokita S, Nishimoto T, Cho Y, Hong K, Weiss R. Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle. Molecular And Cellular Biochemistry 1997, 169: 115-124. PMID: 9089638, DOI: 10.1023/a:1006823611864.Peer-Reviewed Original ResearchConceptsSoluble guanylyl cyclase activityAdult guinea pigsGuanylyl cyclase activityCyclase activityBladder domeSodium nitroprussideGuinea pigsUrinary tract smooth muscleGuanylyl cyclaseAtrial natriuretic factorParticulate guanylyl cyclaseAge-dependent changesAge-specific differencesUrinary tractNatriuretic factorSmooth muscleUreterUrethraRelaxation responseBladderInduced activationNitroprussideTissueRank orderAgeEvidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721. PMID: 8996405, DOI: 10.1016/s0022-5347(01)65257-1.Peer-Reviewed Original ResearchConceptsCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethraEvidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721.. DOI: 10.1097/00005392-199702000-00095.Peer-Reviewed Original ResearchCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethra
1995
Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract
Latifpour J, Fukumoto Y, Weiss R. Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract. Naunyn-Schmiedeberg's Archives Of Pharmacology 1995, 352: 459-468. PMID: 8751073, DOI: 10.1007/bf00169378.Peer-Reviewed Original ResearchConceptsBladder baseSarafotoxin S6cBladder domeUrinary tractETB receptorsET-3Rabbit urinary tractSubtype specificityBQ-123Endothelin receptorsET receptorsReceptor subtypesET-1Human ETASelective ETA receptor antagonistSelective ETB agonistETA receptor antagonistETB receptor subtypesSingle receptor subtypeETA receptorsETB agonistChinese hamster ovary KReceptor antagonistSimilar binding studiesUrethraEffect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract
Wheeler M, Martin T, Weiss R. Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract. Journal Of Urology 1995, 153: 2044-2049. PMID: 7752391, DOI: 10.1016/s0022-5347(01)67399-3.Peer-Reviewed Original ResearchConceptsPhosphatidyl inositol hydrolysisPI hydrolysisCyclic AMP levelsCAMP levelsBladder domeAMP levelsUrinary tract functionEffect of carbacholGuinea-pig ureterAgonist-induced changesBasal cAMP levelsUrinary tractMuscarinic cholinergicTract functionSecond messenger systemsCarbacholNorepinephrinePig ureterSustained increaseUreterUrethraSecond messenger levelsMessenger systemsForskolinTransitory increaseEffect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract
Wheeler M, Martin T, Weiss R. Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract. Journal Of Urology 1995, 153: 2044-2049.. DOI: 10.1097/00005392-199506000-00100.Peer-Reviewed Original ResearchPhosphatidyl inositol hydrolysisPI hydrolysisCyclic AMP levelsCAMP levelsBladder domeAMP levelsUrinary tract functionEffect of carbacholGuinea-pig ureterAgonist-induced changesBasal cAMP levelsUrinary tractMuscarinic cholinergicSecond messenger systemsTract functionCarbacholNorepinephrinePig ureterSustained increaseUreterUrethraSecond messenger levelsMessenger systemsForskolinMessenger levels
1994
Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation
Dokita S, Smith S, Nishimoto T, Wheeler M, Weiss R. Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation. European Journal Of Pharmacology 1994, 266: 269-275. PMID: 7513645, DOI: 10.1016/0922-4106(94)90136-8.Peer-Reviewed Original ResearchConceptsNitric oxide synthase activityTransmural nerve stimulationOxide synthase activityRabbit urethraNerve stimulationNOS activityL-arginineSoluble nitric oxide synthaseNitric oxide synthase inhibitorRelaxation responseNitric oxideCyclic GMPOxide synthase inhibitorNitric oxide synthaseCyclic GMP levelsUrethral relaxationNG-nitroRank orderOxide synthaseSynthase activityNG-methylSynthase inhibitorElectrical stimulationUrethraSame rank order
1993
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract
Yoshida M, Latifpour J, Weiss R. Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract. European Journal Of Pharmacology 1993, 232: 159-167. PMID: 8385616, DOI: 10.1016/0014-2999(93)90769-e.Peer-Reviewed Original ResearchConceptsLower urinary tractBladder baseBladder domeUrinary tractChannel antagonistsRabbit lower urinary tractBay K 8644Channel antagonist receptorsAge-dependent changesDensity of Ca2Age-related changesAntagonist binding sitesReceptor densityPharmacological profileAntagonist receptorsRabbit urethraUrethraAge groupsBmax valuesDays rabbitsAntagonistTractWeeksRank orderBinding sites
1987
Sex differences in function and distribution of alpha 1- and alpha 2-adrenoceptors in rabbit urethra
Morita T, Latifpour J, O'Hollaren B, Wheeler M, Weiss R. Sex differences in function and distribution of alpha 1- and alpha 2-adrenoceptors in rabbit urethra. American Journal Of Physiology 1987, 252: f1124-f1128. PMID: 3035945, DOI: 10.1152/ajprenal.1987.252.6.f1124.Peer-Reviewed Original ResearchConceptsContractile responseFemale urethraMale urethraAlpha 1Rabbit urethraRadioligand receptor binding techniquesFemale rabbit urethraLarger contractile responsesSmall contractile responseAlpha-adrenergic agonistsUrethral smooth muscleReceptor binding techniquesReceptor binding studiesIsolated urethraSmooth muscleContractile propertiesUrethraFemale rabbitsContractile forceAgonistsInduced increasesAlpha 2Binding techniquesNorepinephrineAlpha