1999
A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
KORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Journal Of Urology 1999, 161: 558-565. PMID: 9915448, DOI: 10.1016/s0022-5347(01)61950-5.Peer-Reviewed Original ResearchConceptsL-arginine groupOral L-arginineNitric oxide synthase activityInterstitial cystitis symptomsInterstitial cystitis patientsOxide synthase activityPlacebo groupInterstitial cystitisL-arginineCystitis symptomsCystitis patientsUrinary nitric oxide synthase activityRandomized double-blind trialDouble-blind trialFrequency of painL-arginine treatmentGreater global improvementNitric oxide synthaseUrine of patientsUrine of controlsPain intensityOxide synthaseSynthase activityGlobal improvementPatientsA RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
KORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Journal Of Urology 1999, 161: 558-565.. DOI: 10.1097/00005392-199902000-00055.Peer-Reviewed Original ResearchL-arginine groupOral L-arginineNitric oxide synthase activityInterstitial cystitis symptomsInterstitial cystitis patientsOxide synthase activityPlacebo groupInterstitial cystitisL-arginineCystitis symptomsCystitis patientsUrinary nitric oxide synthase activityRandomized double-blind trialDouble-blind trialFrequency of painL-arginine treatmentGreater global improvementNitric oxide synthaseUrine of patientsUrine of controlsPain intensityOxide synthaseSynthase activityGlobal improvementPatients
1997
Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine
Smith S, Wheeler M, Foster H, Weiss R. Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine. Journal Of Urology 1997, 158: 703-708.. PMID: 9258064, DOI: 10.1097/00005392-199709000-00005.Peer-Reviewed Original ResearchConceptsOral L-arginineL-arginineInterstitial cystitisUrinary nitric oxide synthase activityInterstitial Cystitis Symptom ScoreOral L-arginine treatmentNitric oxide synthase activityLower abdominal painInterstitial cystitis symptomsMethods Ten patientsL-arginine treatmentOxide synthase activityNitric oxide synthaseSelf-controlled studyAbdominal painTEN patientsUrethral painUrinary frequencyCystitis symptomsSymptom scoresOxide synthaseRelated symptomsImmunological responseNitric oxidePatients
1996
Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435.. DOI: 10.1097/00005392-199604000-00098.Peer-Reviewed Original ResearchUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityFemale controlsTract infectionsGMP levelsResults Female patientsCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityAbstract PurposeDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMP
1994
Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine
Smith S, Wheeler M, Weiss R. Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine. Kidney International 1994, 45: 586-591. PMID: 7513034, DOI: 10.1038/ki.1994.76.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNon-infected urineTract infectionsL-arginineUrine nitriteInfected urineUrinary nitric oxide synthase activityNitric oxide synthase activityUrinary nitrite levelsEndogenous sourcesOxide synthase activitySynthase activityMin/Exogenous L-arginineNG-nitroNG-monomethylGriess methodParticulate fractionNitrite levelsUrine fractionsEndogenous productionNitrite productionUrineInfectionElevated nitrite