1999
A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
KORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Journal Of Urology 1999, 161: 558-565. PMID: 9915448, DOI: 10.1016/s0022-5347(01)61950-5.Peer-Reviewed Original ResearchConceptsL-arginine groupOral L-arginineNitric oxide synthase activityInterstitial cystitis symptomsInterstitial cystitis patientsOxide synthase activityPlacebo groupInterstitial cystitisL-arginineCystitis symptomsCystitis patientsUrinary nitric oxide synthase activityRandomized double-blind trialDouble-blind trialFrequency of painL-arginine treatmentGreater global improvementNitric oxide synthaseUrine of patientsUrine of controlsPain intensityOxide synthaseSynthase activityGlobal improvementPatientsA RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
KORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Journal Of Urology 1999, 161: 558-565.. DOI: 10.1097/00005392-199902000-00055.Peer-Reviewed Original ResearchL-arginine groupOral L-arginineNitric oxide synthase activityInterstitial cystitis symptomsInterstitial cystitis patientsOxide synthase activityPlacebo groupInterstitial cystitisL-arginineCystitis symptomsCystitis patientsUrinary nitric oxide synthase activityRandomized double-blind trialDouble-blind trialFrequency of painL-arginine treatmentGreater global improvementNitric oxide synthaseUrine of patientsUrine of controlsPain intensityOxide synthaseSynthase activityGlobal improvementPatients
1997
EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITIS
Wheeler M, Smith S, Saito N, Foster H, Weiss R. EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITIS. Journal Of Urology 1997, 158: 2045-2050. PMID: 9366309, DOI: 10.1016/s0022-5347(01)68150-3.Peer-Reviewed Original ResearchConceptsInterstitial cystitis patientsNitric oxide synthase activityOral L-arginineOxide synthase activityInterstitial cystitisCystitis patientsL-arginineIL-8Oral L-arginine treatmentLong-term oral administrationInducible nitric oxide synthase (iNOS) proteinNitric oxideNitric oxide synthase proteinCyclic guanosine monophosphate levelsNitric oxide synthase pathwayUrinary nitric oxideInterstitial cystitis symptomsL-arginine treatmentInterleukin-8 levelsCytokine IL-8Nitric oxide synthaseSmooth muscle relaxationUrine of patientsGuanosine monophosphate levelsOxide synthase pathway
1996
Nitric oxide synthase induction with renal transplant rejection or infection
Smith S, Wheeler M, Zhang R, Weiss E, Lorber M, Sessa W, Weiss R. Nitric oxide synthase induction with renal transplant rejection or infection. Kidney International 1996, 50: 2088-2093. PMID: 8943494, DOI: 10.1038/ki.1996.533.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRenal transplant patientsNitric oxide synthaseCyclic GMP levelsTransplant patientsTract infectionsNOS activityPost-renal transplantation patientsGMP levelsInducible nitric oxide synthaseNitric oxideRenal allograft rejectionRenal transplant rejectionNitric oxide synthase inductionInducible NOS (iNOS) mRNAUrine of patientsRenal transplantationTransplantation patientsAllograft rejectionTransplant rejectionInducible NOSOxide synthaseNOS mRNAPatientsSynthase induction