2003
Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
Afiatpour P, Latifpour J, Takahashi W, Yono M, Foster HE, Ikeda K, Pouresmail M, Weiss RM. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 2003, 367: 462-472. PMID: 12700883, DOI: 10.1007/s00210-003-0715-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyBinding SitesEndothelin-1Gene ExpressionIodine RadioisotopesMuscle ContractionMuscle, SmoothRadioligand AssayRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsUrinary BladderConceptsETA receptor subtypeSmooth muscle layerReceptor subtypesRat detrusorEndothelin receptorsET receptorsET-1Muscle layerSelective ETA receptor antagonistET receptor systemLarger contractile responsesTotal ET receptorsReceptor subtype mRNAsETA receptor antagonistETB receptor subtypesReal-time reverse transcription-polymerase chain reactionMuscle bath techniqueBladder smooth muscleReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAge-dependent decreaseAge-dependent alterationsReal-time RT-PCRContractile responseSubtype mRNAs
2002
The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate
Takahashi W, Afiatpour P, Foster H, Ikeda K, Wada Y, Weiss RM, Latifpour J. The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate. Naunyn-Schmiedeberg's Archives Of Pharmacology 2002, 366: 166-176. PMID: 12122504, DOI: 10.1007/s00210-002-0575-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesAutoradiographyDiabetes Mellitus, ExperimentalDNA PrimersEndothelin-1Endothelin-3Endothelin-Converting EnzymesGene ExpressionMaleMetalloendopeptidasesMicroscopyOrchiectomyOrgan SizeProstateProtein BindingRadioligand AssayRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsReceptor subtype mRNAsET receptor subtypesSerum testosterone levelsET receptorsRat prostateEffects of castrationReceptor subtypesSubtype mRNAsDorsolateral regionTestosterone levelsET-1Three-month-old SpraguePharmacological propertiesDiabetes-induced reductionET receptor systemET-3 mRNAETB receptor subtypesPost-operative dayReverse transcription-polymerase chain reactionVentral regionECE-1 mRNATranscription-polymerase chain reactionLight microscopy autoradiographyEnzyme-1 mRNAMultiplex reverse transcription-polymerase chain reaction
2001
Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis
Wada Y, Latifpour J, Saito M, Afiatpour P, Weiss R. Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis. BJU International 2001, 88: 950-959. PMID: 11851620, DOI: 10.1046/j.1464-4096.2001.2441.x.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyEndothelin-1Kidney PelvisMaleMuscle ContractionRabbitsRadioligand AssayReceptors, EndothelinConceptsRabbit renal pelvisTotal ET receptorsETA receptor subtypeRenal pelvisET receptorsET-1Age groupsContractile responseEndothelin receptorsPelvic regionReceptor subtypesSpontaneous activityET-1-induced contractile responseOld rabbitsDensities of ETAYoung rabbitsPresence of ETASubtype-selective compoundsReceptor-binding techniquesConcentration-dependent mannerETB subtypeEffect of ageETA receptorsETB receptorsMuscle strips
2000
Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment
Saito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalEndothelin Receptor AntagonistsEndothelin-1InsulinIodine RadioisotopesMaleOrgan SizeProstateProtein IsoformsRadioligand AssayRandom AllocationRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneUp-RegulationConceptsInduction of diabetesET receptorsReverse transcription-polymerase chain reactionRat prostateInsulin treatmentDiabetic animalsReceptor subtypesDiabetes-induced upregulationET receptor densityEndothelin receptor subtypesET receptor subtypesSTZ-injected ratsSerum testosterone levelsRadioligand receptor bindingDiabetic rat prostateTranscription-polymerase chain reactionDiabetic ratsETB receptorsSmaller prostatesEndothelin receptorsProstatic stromaTestosterone levelsReceptor densityPharmacological profileAutoradiographic study
1995
Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract
Latifpour J, Fukumoto Y, Weiss R. Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract. Naunyn-Schmiedeberg's Archives Of Pharmacology 1995, 352: 459-468. PMID: 8751073, DOI: 10.1007/bf00169378.Peer-Reviewed Original ResearchConceptsBladder baseSarafotoxin S6cBladder domeUrinary tractETB receptorsET-3Rabbit urinary tractSubtype specificityBQ-123Endothelin receptorsET receptorsReceptor subtypesET-1Human ETASelective ETA receptor antagonistSelective ETB agonistETA receptor antagonistETB receptor subtypesSingle receptor subtypeETA receptorsETB agonistChinese hamster ovary KReceptor antagonistSimilar binding studiesUrethra
1993
The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate
Fukumoto Y, Yoshida M, Dokita S, Kamai T, Weiss R, Latifpour J. The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate. Journal Of Urology 1993, 149: 1602-1606. PMID: 8388963, DOI: 10.1016/s0022-5347(17)36459-5.Peer-Reviewed Original ResearchConceptsMuscarinic cholinergic receptorsBeta adrenergicRat prostateCholinergic receptorsInsulin treatmentMuscarinic receptorsInsulin-treated diabetic animalsEarly insulin treatmentDiabetes-induced alterationsInduction of diabetesInsulin-treated diabeticsOnset of diabetesAdministration of streptozotocinDiabetes-induced downregulationDiabetic rat prostateGroups of ratsBeta-adrenergic agonistsHigh-affinity agonistDiabetic animalsMuscarinic agonistsAdrenergic agonistsAdrenergicProstateDiabetesAgonists
1991
Beta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol
Gousse A, Yoshida M, Weiss R, Latifpour J. Beta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol. The Prostate 1991, 19: 121-131. PMID: 1681523, DOI: 10.1002/pros.2990190205.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDihydroalprenololDose-Response Relationship, DrugDrinkingInositolInsulinIsoproterenolMaleOrgan SizePropanolaminesPropranololProstateRadioligand AssayRatsRats, Inbred StrainsReceptors, Adrenergic, betaStreptozocinUrinationConceptsBeta-adrenergic receptorsAdrenergic receptorsInsulin levelsRadioligand receptor binding techniquesSelective beta-adrenergic antagonistsHigh blood glucose levelsLower serum insulin levelsAdrenergic receptor alterationsInduction of diabetesInsulin-treated diabeticsSerum insulin levelsBeta-adrenergic receptor alterationsAutonomic nervous systemBlood glucose levelsBeta-adrenergic antagonistsDiabetic rat prostateGroups of ratsReceptor binding techniquesEffect of insulinMale reproductive systemHigh water intakeDietary myoinositolDiabetes mellitusUrine outputDiabetic rats
1989
The Characterization of Beta-Adrenergic Receptor Subtypes of the Upper and Lower Renal Pelvis in Rabbits
Kondo S, Latifpour J, Morita T, Weiss R. The Characterization of Beta-Adrenergic Receptor Subtypes of the Upper and Lower Renal Pelvis in Rabbits. Journal Of Urology 1989, 142: 1099-1101. PMID: 2571737, DOI: 10.1016/s0022-5347(17)39004-3.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsBeta 2 subtypeRenal pelvisRabbit renal pelvisLower pelvisSelective antagonistBeta-2 selective antagonistBeta-adrenergic receptor subtypesUpper renal pelvisBeta 2 receptorsRadioligand binding techniquesBeta-1 selective antagonistReceptor subtypesBeta receptorsPelvisBeta 1ReceptorsSubtypesICIBinding techniquesSaturation studiesSignificant differencesSites BmaxAntagonistGreater proportion