2008
Prostate expression of endothelins and their receptors in rat growth
Wada Y, Takahashi W, Latifpour J, Weiss RM, Matsumoto K, Matsui K, Yamada, Imamura T. Prostate expression of endothelins and their receptors in rat growth. Reproduction Fertility And Development 2008, 20: 750-759. PMID: 18842177, DOI: 10.1071/rd08052.Peer-Reviewed Original ResearchConceptsET-1Receptors ETAProstate growthProstate lobesET-3Role of ETAVentral prostate lobeReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMultiplex reverse transcription-polymerase chain reactionMRNA expression levelsProstate expressionEndothelinMitogenic effectProstate cellsMRNA expressionMembrane particulatesHigh expressionMonthsWeeksEnzyme 1Chain reactionExpression levelsRat growthRats
2006
Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract
Yono M, Foster HE, Weiss RM, Latifpour J. Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract. Journal Of Urology 2006, 176: 1214-1219. PMID: 16890728, DOI: 10.1016/j.juro.2006.04.038.Peer-Reviewed Original ResearchConceptsRat genitourinary tractLower urinary tract symptomsUrinary tract symptomsBenign prostatic hyperplasiaAdrenoceptor antagonistGenitourinary tractTract symptomsBladder baseProstatic hyperplasiaDorsolateral prostateYoung ratsIsolated muscle bathMaximum contractile responseTranscriptase-polymerase chain reaction techniqueRadioligand receptor bindingReverse transcriptase-polymerase chain reaction techniqueSignificant age-dependent differencesAge-dependent differencesAge related changesHigher body weightAge related differencesContractile responseAdrenoceptor densityAdrenoceptor subtypesBladder dome
2004
Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens
Yono M, Latifpour J, Takahashi W, Pouresmail M, Afiatpour P, Weiss RM. Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens. Journal Of Receptors And Signal Transduction 2004, 24: 53-66. PMID: 15344879, DOI: 10.1081/rrs-120034106.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAspartic Acid EndopeptidasesDNA PrimersDown-RegulationEndothelin-1Endothelin-3Endothelin-Converting EnzymesKineticsMaleMetalloendopeptidasesPolymerase Chain ReactionProtein BindingRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerVas DeferensConceptsEndothelin receptor systemET receptor systemAge-related changesWeek old ratsET receptorsMonth old ratsOld ratsET-1Receptor systemVas deferensReceptor subtypesRat vasET-3MRNA levelsAge groupsFunctional ET receptorsTotal ET receptorsReceptor subtype mRNAsReal-time reverse transcription-polymerase chain reactionRadioligand receptor bindingReverse transcription-polymerase chain reactionPredominant mRNA expressionRat vas deferensTranscription-polymerase chain reactionRadioligand receptor binding assays
2003
Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
Afiatpour P, Latifpour J, Takahashi W, Yono M, Foster HE, Ikeda K, Pouresmail M, Weiss RM. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 2003, 367: 462-472. PMID: 12700883, DOI: 10.1007/s00210-003-0715-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyBinding SitesEndothelin-1Gene ExpressionIodine RadioisotopesMuscle ContractionMuscle, SmoothRadioligand AssayRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsUrinary BladderConceptsETA receptor subtypeSmooth muscle layerReceptor subtypesRat detrusorEndothelin receptorsET receptorsET-1Muscle layerSelective ETA receptor antagonistET receptor systemLarger contractile responsesTotal ET receptorsReceptor subtype mRNAsETA receptor antagonistETB receptor subtypesReal-time reverse transcription-polymerase chain reactionMuscle bath techniqueBladder smooth muscleReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAge-dependent decreaseAge-dependent alterationsReal-time RT-PCRContractile responseSubtype mRNAs
2002
Quantification of endothelins, their receptors, and endothelin-converting enzyme mRNA in rat genitourinary tract using real-time RT-PCR
Yono M, Takahashi W, Pouresmail M, Johnson DR, Foster HE, Weiss RM, Latifpour J. Quantification of endothelins, their receptors, and endothelin-converting enzyme mRNA in rat genitourinary tract using real-time RT-PCR. Journal Of Pharmacological And Toxicological Methods 2002, 48: 87-95. PMID: 14565565, DOI: 10.1016/s1056-8719(03)00022-4.Peer-Reviewed Original ResearchConceptsRat genitourinary tractGenitourinary tractET-1MRNA expressionET-3Receptor subtype mRNA expressionReceptor subtype mRNAsETA receptor subtypeReal-time reverse transcription-polymerase chain reactionSubtype mRNA expressionReverse transcription-polymerase chain reactionReceptor-mediated mechanismTranscription-polymerase chain reactionReal-time RT-PCRSubtype mRNAsPolymerase chain reactionReceptor subtypesRat bladderReal-time PCRDorsolateral prostateReceptor mRNAVentral prostateECE-1Computer-assisted programVas deferens
1995
Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705. PMID: 7715014, DOI: 10.1016/s0022-5347(01)67508-6.Peer-Reviewed Original ResearchConceptsElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsBladder detrusor
1990
Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders.
Wheeler M, Pontari M, Nishimoto T, Weiss R. Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 277-83. PMID: 2366184.Peer-Reviewed Original Research