2000
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Derweesh I, Wheeler M, Weiss R. Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 969-74. PMID: 10945848.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAdenylate Cyclase ToxinAdenylyl CyclasesAdrenergic beta-AgonistsAgingAnimalsBlotting, WesternCarbazolesColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsGTP-Binding ProteinsIndolesIsoproterenolMuscle, SmoothPertussis ToxinPyrrolesRatsReceptors, Adrenergic, betaUrinary BladderVirulence Factors, BordetellaConceptsPertussis toxin-catalyzed ADP-ribosylationToxin-catalyzed ADP-ribosylationRat bladderPertussis toxin-sensitive G proteinToxin-sensitive G proteinResponses of bladdersRat urinary bladderAdenylyl cyclaseTreatment of bladderBeta-adrenergic stimulationADP-ribosylationG proteinsAdenylyl cyclase activityResponsive adenylyl cyclaseAge-dependent declineWestern blot analysisG-protein contentUrinary bladderPertussis toxinBladderIsoproterenol stimulationRelaxation responseCyclase activityFunctional activityBlot analysis
1995
Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705. PMID: 7715014, DOI: 10.1016/s0022-5347(01)67508-6.Peer-Reviewed Original ResearchConceptsElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsBladder detrusor
1993
The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate
Fukumoto Y, Yoshida M, Dokita S, Kamai T, Weiss R, Latifpour J. The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate. Journal Of Urology 1993, 149: 1602-1606. PMID: 8388963, DOI: 10.1016/s0022-5347(17)36459-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesDiabetes Mellitus, ExperimentalDown-RegulationInsulinMaleProstateRadioligand AssayRatsRats, Sprague-DawleyReceptors, Adrenergic, betaReceptors, MuscarinicTime FactorsConceptsMuscarinic cholinergic receptorsBeta adrenergicRat prostateCholinergic receptorsInsulin treatmentMuscarinic receptorsInsulin-treated diabetic animalsEarly insulin treatmentDiabetes-induced alterationsInduction of diabetesInsulin-treated diabeticsOnset of diabetesAdministration of streptozotocinDiabetes-induced downregulationDiabetic rat prostateGroups of ratsBeta-adrenergic agonistsHigh-affinity agonistDiabetic animalsMuscarinic agonistsAdrenergic agonistsAdrenergicProstateDiabetesAgonists
1991
Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes. Diabetes 1991, 40: 1150-1156. PMID: 1657672, DOI: 10.2337/diab.40.9.1150.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsSucrose-fed ratsBladder domeDetrusor stripsDiabetic ratsHigher serum glucose levelsLower serum insulin levelsLarger contractile responsesMuscarinic receptor upregulationHigher urine outputCarbachol-induced contractionDiabetes-induced alterationsMuscarinic cholinergic receptorsSerum insulin levelsSTZ-induced diabetesSerum glucose levelsIsoproterenol-induced relaxationAge-matched controlsLower body weightSucrose-fed animalsBladder hypertrophyContractile responseDiabetic bladderUrine outputRelaxed KClDifferential regulation of bladder beta-adrenergic and muscarinic cholinergic receptors in experimental diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential regulation of bladder beta-adrenergic and muscarinic cholinergic receptors in experimental diabetes. Diabetes 1991, 40: 1150-1156. DOI: 10.2337/diabetes.40.9.1150.Peer-Reviewed Original ResearchBeta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol
Gousse A, Yoshida M, Weiss R, Latifpour J. Beta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol. The Prostate 1991, 19: 121-131. PMID: 1681523, DOI: 10.1002/pros.2990190205.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDihydroalprenololDose-Response Relationship, DrugDrinkingInositolInsulinIsoproterenolMaleOrgan SizePropanolaminesPropranololProstateRadioligand AssayRatsRats, Inbred StrainsReceptors, Adrenergic, betaStreptozocinUrinationConceptsBeta-adrenergic receptorsAdrenergic receptorsInsulin levelsRadioligand receptor binding techniquesSelective beta-adrenergic antagonistsHigh blood glucose levelsLower serum insulin levelsAdrenergic receptor alterationsInduction of diabetesInsulin-treated diabeticsSerum insulin levelsBeta-adrenergic receptor alterationsAutonomic nervous systemBlood glucose levelsBeta-adrenergic antagonistsDiabetic rat prostateGroups of ratsReceptor binding techniquesEffect of insulinMale reproductive systemHigh water intakeDietary myoinositolDiabetes mellitusUrine outputDiabetic rats
1989
The Characterization of Beta-Adrenergic Receptor Subtypes of the Upper and Lower Renal Pelvis in Rabbits
Kondo S, Latifpour J, Morita T, Weiss R. The Characterization of Beta-Adrenergic Receptor Subtypes of the Upper and Lower Renal Pelvis in Rabbits. Journal Of Urology 1989, 142: 1099-1101. PMID: 2571737, DOI: 10.1016/s0022-5347(17)39004-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAnimalsDihydroalprenololKidney PelvisMalePropanolaminesRabbitsRadioligand AssayReceptors, Adrenergic, betaTissue DistributionConceptsBeta-adrenergic receptorsBeta 2 subtypeRenal pelvisRabbit renal pelvisLower pelvisSelective antagonistBeta-2 selective antagonistBeta-adrenergic receptor subtypesUpper renal pelvisBeta 2 receptorsRadioligand binding techniquesBeta-1 selective antagonistReceptor subtypesBeta receptorsPelvisBeta 1ReceptorsSubtypesICIBinding techniquesSaturation studiesSignificant differencesSites BmaxAntagonistGreater proportionCharacterization of Autonomic Receptors in Neonatal Urinary Tract Smooth Muscle
Latifpour J, Morita T, O'Hollaren B, Kondo S, Weiss R. Characterization of Autonomic Receptors in Neonatal Urinary Tract Smooth Muscle. Neonatology 1989, 13: 1-10. PMID: 2570683, DOI: 10.1159/000457575.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic AgonistsAnimalsAnimals, NewbornCarbacholClonidineDihydroalprenololDose-Response Relationship, DrugIn Vitro TechniquesMuscle ContractionMuscle, SmoothPrazosinQuinuclidinyl BenzilateRabbitsReceptors, Adrenergic, alphaReceptors, Adrenergic, betaReceptors, MuscarinicUrinary TractYohimbineConceptsUrinary tract smooth muscleSmooth muscleAutonomic receptorsBeta-adrenergic receptor densityAlpha-1 adrenergic receptorsNeonatal urinary tractAlpha 2 receptorsAlpha 1 receptorsAlpha-adrenergic agonistsFunctional muscarinic receptorsRelaxant responsesBladder baseBladder domeMuscarinic receptorsUrinary tractReceptor densityAdult rabbitsAlpha 2ReceptorsMuscleAgonistsRank orderRabbitsHigher numberIsoproterenol
1986
Characterization of Functional Beta-Adrenoceptor Subtypes in Rabbit Urinary Bladder Smooth Muscle
MORITA T, KONDO S, TSUCHIDA S, WEISS R. Characterization of Functional Beta-Adrenoceptor Subtypes in Rabbit Urinary Bladder Smooth Muscle. The Tohoku Journal Of Experimental Medicine 1986, 149: 389. PMID: 3022421, DOI: 10.1620/tjem.149.389.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButoxamineDobutamineIsoproterenolMaleMetoprololMuscle ContractionMuscle, SmoothPropranololRabbitsReceptors, Adrenergic, betaTerbutalineUrinary BladderConceptsTrigonal muscleRelaxant responsesM isoproterenolRabbit urinary bladder smooth muscleUrinary bladder smooth muscleSignificant relaxant responseSpontaneous contractile forceUrinary bladder domeBeta-adrenoceptor subtypesBeta-adrenoceptor agonistsBeta-adrenoceptor stimulationMaximum relaxant responseBladder smooth muscleM butoxamineM metoprololSelective betaBladder domeMuscle stripsM propranololSpecific betaDetrusorSmooth muscleMale rabbitsIsoproterenolContractile force