2006
Pacemaker activity in the upper urinary tract
Weiss RM, Tamarkin FJ, Wheeler MA. Pacemaker activity in the upper urinary tract. Journal Of Smooth Muscle Research 2006, 42: 103. PMID: 17099294, DOI: 10.1540/jsmr.42.103.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBiological ClocksElectromyographyGene Expression RegulationHumansMuscle, SmoothNeurons, AfferentPeristalsisProto-Oncogene Proteins c-kitUrinary TractUrinary Tract Physiological PhenomenaConceptsSmooth muscle cellsTypical smooth muscle cellsMuscle cellsUreteral peristalsisCapsaicin-sensitive sensory afferentsAlpha-smooth muscle actinNormal ureteral peristalsisUpper urinary tractUreteral peristaltic activityUrinary collecting systemTyrosine kinase receptorsSensory afferentsUrinary tractEndogenous releasePeristaltic activityPacemaker activityMuscle actinAction potentialsPacemaker siteC-kitPacemaker cellsProximal portionCollecting systemSparse immunoreactivityElectrical activity
2005
Regulation of cyclic nucleotides in the urinary tract
Wheeler MA, Ayyagari RR, Wheeler GL, Weiss RM. Regulation of cyclic nucleotides in the urinary tract. Journal Of Smooth Muscle Research 2005, 41: 1. PMID: 15855736, DOI: 10.1540/jsmr.41.1.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAgingAnimalsGTP-Binding ProteinsHumansMuscle, SmoothNucleotides, CyclicPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesUrinary BladderUrinary Tract Physiological PhenomenaConceptsUrinary tractRelaxation responseLow compliance bladderSmooth muscle functionG proteinsCyclic AMP productionStimulatory G proteinCyclic nucleotide levelsG protein isoformsUrge incontinenceTreatment optionsProstate cancerMuscle functionDisease processFamily of phosphodiesterasesSpecific PDE inhibitorsAMP productionPDE inhibitorsBladderAdenylyl cyclasePDE isoformsTractPharmacological potentialCancerPDE expression