2019
Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target
Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM. Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target. Molecular Cancer Therapeutics 2019, 18: molcanther.1079.2017. PMID: 30381445, PMCID: PMC6363894, DOI: 10.1158/1535-7163.mct-17-1079.Peer-Reviewed Original ResearchConceptsBladder cancer cell linesBladder tumorsBladder cancerCancer cell linesHigh-grade bladder cancer cell linesCancer xenograft mouse modelBladder cancer growthAggressive bladder cancerPotential therapeutic targetHuman bladder tumorsXenograft mouse modelBladder cancer progressionCell linesBladder tumor cellsCurative potentialOptimal treatmentTumor gradePatient outcomesReduced cell migrationTumor volumeTumor categoryMouse modelTherapeutic targetTumor aggressivenessCancer growth
2004
Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
Kang WS, Tamarkin FJ, Wheeler MA, Weiss RM. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation. Journal Of Pharmacology And Experimental Therapeutics 2004, 310: 452-458. PMID: 15082754, DOI: 10.1124/jpet.104.066506.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary cyclic GMPNitric oxide synthaseEscherichia coli lipopolysaccharideLPS treatmentNOS activityColi lipopolysaccharideNitric oxideEndothelial nitric oxide synthaseDependent NOS activityCyclic GMPInduction of inflammationPhosphorylation of eNOSBladder inflammationLPS injectionHuman eNOSENOS proteinIntraperitoneal injectionFemale miceBladder urotheliumInflammatory responseMolecule nitric oxideMouse modelInflammationENOS phosphorylation
2001
Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model
Wheeler M, Yoon J, Olsson L, Weiss R. Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model. European Journal Of Pharmacology 2001, 417: 239-248. PMID: 11334856, DOI: 10.1016/s0014-2999(01)00911-6.Peer-Reviewed Original ResearchAdministration, IntravesicalAnimalsBlotting, WesternCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDinoprostoneFemaleInflammationInjections, IntraperitonealIsoenzymesLipopolysaccharidesMembrane ProteinsNiflumic AcidNitratesNitric OxideNitric Oxide DonorsNitric Oxide SynthaseOxidantsPenicillamineProstaglandin-Endoperoxide SynthasesProtaminesRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionRNA, MessengerUp-RegulationUrinary Bladder
2000
Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment
Saito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalEndothelin Receptor AntagonistsEndothelin-1InsulinIodine RadioisotopesMaleOrgan SizeProstateProtein IsoformsRadioligand AssayRandom AllocationRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneUp-RegulationConceptsInduction of diabetesET receptorsReverse transcription-polymerase chain reactionRat prostateInsulin treatmentDiabetic animalsReceptor subtypesDiabetes-induced upregulationET receptor densityEndothelin receptor subtypesET receptor subtypesSTZ-injected ratsSerum testosterone levelsRadioligand receptor bindingDiabetic rat prostateTranscription-polymerase chain reactionDiabetic ratsETB receptorsSmaller prostatesEndothelin receptorsProstatic stromaTestosterone levelsReceptor densityPharmacological profileAutoradiographic study
1999
Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter
Saito M, Weiss R, Latifpour J. Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter. International Journal Of Urology 1999, 6: 361-368. PMID: 10445306, DOI: 10.1046/j.1442-2042.1999.00074.x.Peer-Reviewed Original Research
1998
Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder.
Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 1203-8. PMID: 9495884.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary tract infectionIntravesical instillationLocalized inflammatory responseInflammatory responseRat bladderSystemic bacterial lipopolysaccharideInstillation of lipopolysaccharideRat urinary bladderNitric oxide synthaseIL-6 mRNATract infectionsBladder instillationIL-10Urinary nitrateRegulate cytokinesINOS activityIntraperitoneal injectionNOS activityOxide synthaseUrinary bladderImportance of lipopolysaccharideINOS proteinInstillationCGMP levels
1997
Experimental Diabetes Upregulates the Expression of Uretereral Endothelin Receptors
Nakamura I, Saito M, Fukumoto Y, Yoshida M, Nishi K, Weiss R, Latifpour J. Experimental Diabetes Upregulates the Expression of Uretereral Endothelin Receptors. Peptides 1997, 18: 1091-1093. PMID: 9357071, DOI: 10.1016/s0196-9781(97)00026-0.Peer-Reviewed Original Research
1996
Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens
Saito M, Nishi K, Fukumoto Y, Weiss R, Latifpour J. Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens. Biochemical Pharmacology 1996, 52: 1593-1598. PMID: 8937475, DOI: 10.1016/s0006-2952(96)00565-5.Peer-Reviewed Original ResearchConceptsET receptorsAge-matched controlsRat vasa deferentiaIRL 1620BQ-610Vasa deferentiaET-1ET-3ETA receptor subtypeGroups of ratsDiabetic ratsExperimental diabetesEndothelin receptorsPlasma levelsReceptor subtypesInsulin treatmentPeripheral tissuesRat vasPharmacological profileReceptor characteristicsFmol/StreptozotocinReceptorsWeeksEndothelin
1994
Diabetes-Induced Alterations in the Properties of Muscarinic Cholinergic Receptors in Rat Vas Deferens
Kamai T, Fukumoto Y, Gousse A, Yoshida M, Davenport T, Weiss R, Latifpour J. Diabetes-Induced Alterations in the Properties of Muscarinic Cholinergic Receptors in Rat Vas Deferens. Journal Of Urology 1994, 152: 1017-1021. PMID: 8051725, DOI: 10.1016/s0022-5347(17)32646-0.Peer-Reviewed Original ResearchConceptsMuscarinic cholinergic receptorsRat vasVas deferensCholinergic receptorsMuscarinic receptorsDiabetic insulin-treated ratsMuscarinic cholinergic receptor subtypesMuscarinic cholinergic receptor densityMembrane particulatesCholinergic receptor densityDiabetes-Induced AlterationsAF-DX 116Cholinergic receptor subtypesMuscarinic cholinergic antagonistAdministration of insulinInsulin-treated ratsAge-matched controlsRat vas deferensRank orderAdditional pharmacological studiesDiabetic ratsBladder domeCerebral cortexCholinergic antagonistsReceptor subtypesReversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors
Fukomoto Y, Yoshida M, Weiss R, Latifpour J. Reversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors. Diabetes 1994, 43: 819-826. PMID: 8194669, DOI: 10.2337/diab.43.6.819.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBody WeightCell MembraneDiabetes Mellitus, ExperimentalDiaminesDiuresisDrinking BehaviorInsulinKineticsMaleMyocardiumOrgan SizeParasympatholyticsPiperidinesPirenzepineProstateQuinuclidinyl BenzilateRatsRats, Sprague-DawleyReceptors, MuscarinicSucroseTestosteroneUp-RegulationUrinary BladderConceptsAge-matched control ratsMuscarinic receptorsRat bladder domeBladder domeDiuretic ratsDiabetic ratsControl ratsSTZ-induced diabetic ratsInsulin-treated diabetic ratsDiabetes-induced upregulationEarly insulin treatmentSucrose-fed ratsGroups of ratsIncreased water intakeBladder hypertrophyUrine outputInsulin treatmentRadioligand receptorRatsDiabetesDiuretic stateReceptorsWater intakeWeeksUpregulation
1992
Effect of Insulin and Dietary Myoinositol on Muscarinic Receptor Alterations in Diabetic Rat Bladder
Latifpour J, Gousse A, Yoshida M, Weiss R. Effect of Insulin and Dietary Myoinositol on Muscarinic Receptor Alterations in Diabetic Rat Bladder. Journal Of Urology 1992, 147: 760-763. PMID: 1538479, DOI: 10.1016/s0022-5347(17)37374-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalInositolInsulinReceptors, MuscarinicUp-RegulationUrinary BladderConceptsDietary myoinositolBladder domeMuscarinic receptorsReceptor densityLower serum insulin levelsDiabetic rat bladderMuscarinic receptor alterationsStreptozotocin-injected ratsMuscarinic receptor densitySerum insulin levelsHigher serum glucoseGroups of ratsRadioligand receptor binding assaysEffect of insulinReceptor binding assaysHigh water intakeUrine outputDiabetic ratsReceptor alterationsInsulin levelsSerum glucoseRat bladderRatsInsulinInduced abnormalities