2010
Effect of mitomycin C on concentrations of vascular endothelial growth factor and its receptors in bladder cancer cells and in bladders of rats intravesically instilled with mitomycin C
Verma A, DeGrado J, Hittelman AB, Wheeler MA, Kaimakliotis HZ, Weiss RM. Effect of mitomycin C on concentrations of vascular endothelial growth factor and its receptors in bladder cancer cells and in bladders of rats intravesically instilled with mitomycin C. BJU International 2010, 107: 1154-1161. PMID: 20735383, DOI: 10.1111/j.1464-410x.2010.09543.x.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorVascular endothelial growth factor receptor 2Bladder cancer cellsVEGF receptor 1Bladder of ratsEndothelial growth factorVEGFR-2 mRNAMitomycin CVEGFR-2 proteinCancer cellsSurvivin siRNAVEGF concentrationsMMC concentrationsUrinary vascular endothelial growth factorGrowth factorVEGFR-2 concentrationsGrowth factor receptor 2Superficial bladder cancerTransitional cell carcinomaMMC treatmentEndothelial growth factor receptor 2Factor receptor 2Interleukin-6 mRNAEffective intravesical treatmentLower MMC concentrations
2003
Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle
Takahashi W, Yono M, Wada Y, Ikeda K, Weiss R, Latifpour J. Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle. BJU International 2003, 92: 803-809. PMID: 14616470, DOI: 10.1046/j.1464-410x.2003.04466.x.Peer-Reviewed Original ResearchConceptsExpression of endothelinETB receptor subtypesET receptorsECE-1 mRNARat seminal vesicleReceptor subtypesSeminal vesiclesET-1Slide-mounted frozen sectionsET receptor systemET-3 mRNATotal ET receptorsETA receptor subtypeSprague-Dawley ratsReverse transcription-polymerase chain reactionExpression levelsExpression of ETAEffects of castrationEndothelin-converting enzymeMultiplex reverse transcription-polymerase chain reactionPolymerase chain reactionSmooth muscleET-3Autoradiographic studyFrozen sections
2002
The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate
Takahashi W, Afiatpour P, Foster H, Ikeda K, Wada Y, Weiss RM, Latifpour J. The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate. Naunyn-Schmiedeberg's Archives Of Pharmacology 2002, 366: 166-176. PMID: 12122504, DOI: 10.1007/s00210-002-0575-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesAutoradiographyDiabetes Mellitus, ExperimentalDNA PrimersEndothelin-1Endothelin-3Endothelin-Converting EnzymesGene ExpressionMaleMetalloendopeptidasesMicroscopyOrchiectomyOrgan SizeProstateProtein BindingRadioligand AssayRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsReceptor subtype mRNAsET receptor subtypesSerum testosterone levelsET receptorsRat prostateEffects of castrationReceptor subtypesSubtype mRNAsDorsolateral regionTestosterone levelsET-1Three-month-old SpraguePharmacological propertiesDiabetes-induced reductionET receptor systemET-3 mRNAETB receptor subtypesPost-operative dayReverse transcription-polymerase chain reactionVentral regionECE-1 mRNATranscription-polymerase chain reactionLight microscopy autoradiographyEnzyme-1 mRNAMultiplex reverse transcription-polymerase chain reaction
2001
Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model
Wheeler M, Yoon J, Olsson L, Weiss R. Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model. European Journal Of Pharmacology 2001, 417: 239-248. PMID: 11334856, DOI: 10.1016/s0014-2999(01)00911-6.Peer-Reviewed Original ResearchAdministration, IntravesicalAnimalsBlotting, WesternCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDinoprostoneFemaleInflammationInjections, IntraperitonealIsoenzymesLipopolysaccharidesMembrane ProteinsNiflumic AcidNitratesNitric OxideNitric Oxide DonorsNitric Oxide SynthaseOxidantsPenicillamineProstaglandin-Endoperoxide SynthasesProtaminesRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionRNA, MessengerUp-RegulationUrinary BladderRegulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland
Ikeda K, Wada Y, Sanematsu H, Foster HE, Shin D, Weiss RM, Latifpour J. Regulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland. Journal Of Endocrinology 2001, 168: 163-175. PMID: 11139780, DOI: 10.1677/joe.0.1680163.Peer-Reviewed Original ResearchConceptsEndothelin-converting enzyme-1Rat adrenal glandET receptor subtypesInduction of diabetesAdrenal glandReceptor subtypesETB receptorsExperimental diabetesAge-matched control ratsECE-1 mRNA levelsET-3 mRNAPredominant receptor subtypeDiabetes-induced changesEndothelin receptor subtypesInsulin-treated diabeticsSecretion of steroidsReceptor subtypes ETARadioligand receptor bindingAdrenal gland sizeET-1 mRNAExpression levelsRegulatory effectsVascular toneET receptorsEndothelin action
2000
Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment
Saito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalEndothelin Receptor AntagonistsEndothelin-1InsulinIodine RadioisotopesMaleOrgan SizeProstateProtein IsoformsRadioligand AssayRandom AllocationRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneUp-RegulationConceptsInduction of diabetesET receptorsReverse transcription-polymerase chain reactionRat prostateInsulin treatmentDiabetic animalsReceptor subtypesDiabetes-induced upregulationET receptor densityEndothelin receptor subtypesET receptor subtypesSTZ-injected ratsSerum testosterone levelsRadioligand receptor bindingDiabetic rat prostateTranscription-polymerase chain reactionDiabetic ratsETB receptorsSmaller prostatesEndothelin receptorsProstatic stromaTestosterone levelsReceptor densityPharmacological profileAutoradiographic studyEXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-β
IKEDA K, WADA Y, FOSTER H, WANG Z, WEISS R, LATIFPOUR J. EXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-β. Journal Of Urology 2000, 164: 180-185. PMID: 10840456, DOI: 10.1016/s0022-5347(05)67491-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalMaleProstateRatsRats, Sprague-DawleyRNA, MessengerTransforming Growth Factor betaConceptsSerum testosterone levelsDiabetic rat prostateTestosterone levelsRat prostateProstatic weightProtein levelsStromal cellsAge-matched control ratsGrowth factorInsulin-treated diabeticsInduction of diabetesProstatic stromal cellsSemi-quantitative Western blottingTGF-beta expressionTGF-beta2 expressionTransforming Growth FactorAndrogen-dependent processesExperimental diabetesMultiplex RT-PCRControl ratsImmunohistochemical studyTGF-beta2TGF-beta1Prostate glandProstateExpression and localization of basic fibroblast growth factor in diabetic rat prostate
Wang Z, Ikeda K, Wada Y, Foster H, Weiss R, Latifpour J. Expression and localization of basic fibroblast growth factor in diabetic rat prostate. BJU International 2000, 85: 945-952. PMID: 10792180, DOI: 10.1046/j.1464-410x.2000.00597.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternDiabetes Mellitus, ExperimentalFibroblast Growth Factor 2ImmunohistochemistryMaleProstateRatsRats, Sprague-DawleyConceptsBenign prostatic hyperplasiaDiabetic ratsExpression of FGF2Testosterone levelsRat prostateLow serum testosterone levelsHuman benign prostatic hyperplasiaAge-matched control ratsWestern blottingSerum testosterone levelsPolymerase chain reaction studiesDiabetic rat prostateReverse transcriptase-polymerase chain reaction studiesGroups of ratsBasic fibroblast growth factorImmuno-histochemical studyFibroblast growth factor-2Fibroblast growth factorProstatic sectionsFGF-2 mRNAGrowth factor 2Smaller prostatesProstatic hyperplasiaProstatic sizeProstatic growthGene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
Saito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.Peer-Reviewed Original ResearchConceptsRat bladder domeEndothelin receptorsBladder domeInsulin treatmentReceptor subtypesFunctional endothelin receptorsMammalian urinary tractEndothelin receptor subtypesInduction of diabetesAge-matched controlsReceptor alterationsExperimental diabetesUrinary tractPharmacological characterizationPharmacological profileMuscular layerMRNA upregulationAutoradiographic studyTranscription-polymerase chain reaction dataReceptorsExpression levelsDiabetesTissue componentsSubtypesTreatment
1999
Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter
Saito M, Weiss R, Latifpour J. Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter. International Journal Of Urology 1999, 6: 361-368. PMID: 10445306, DOI: 10.1046/j.1442-2042.1999.00074.x.Peer-Reviewed Original Research
1998
Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder.
Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 1203-8. PMID: 9495884.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary tract infectionIntravesical instillationLocalized inflammatory responseInflammatory responseRat bladderSystemic bacterial lipopolysaccharideInstillation of lipopolysaccharideRat urinary bladderNitric oxide synthaseIL-6 mRNATract infectionsBladder instillationIL-10Urinary nitrateRegulate cytokinesINOS activityIntraperitoneal injectionNOS activityOxide synthaseUrinary bladderImportance of lipopolysaccharideINOS proteinInstillationCGMP levelsProperties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes
Nishi K, Wada Y, Saito M, Foster H, Weiss R, Latifpour J. Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes. Urologia Internationalis 1998, 61: 147-153. PMID: 9933834, DOI: 10.1159/000030311.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AntagonistsAnalysis of VarianceAnimalsBinding SitesCulture TechniquesDiabetes Mellitus, ExperimentalDisease Models, AnimalDown-RegulationLinear ModelsMaleProstateRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReference ValuesSpleenStreptozocinSubmandibular GlandVas DeferensConceptsRat prostateAlpha-1 adrenergic receptorsInduction of diabetesSTZ-induced diabetesWeeks of streptozotocinDiabetic rat prostateSimilar pharmacological profileReceptor subtype specificityExperimental diabetesAlpha1A-subtypeRat submaxillary glandReceptor-binding experimentsRat vasPharmacological profileDiabetesProstateSubtype specificityPharmacological propertiesKi valuesSubmaxillary glandRat spleenPrazosinWB4101BMY7378Spiperone
1997
Muscarinic Receptor Subtypes and Receptor‐Coupled Phosphatidylinositol Hydrolysis in Rat Bladder Smooth Muscle
Mimata H, Nomura Y, Emoto A, Latifpour J, Wheeler M, Weiss R. Muscarinic Receptor Subtypes and Receptor‐Coupled Phosphatidylinositol Hydrolysis in Rat Bladder Smooth Muscle. International Journal Of Urology 1997, 4: 591-596. PMID: 9477190, DOI: 10.1111/j.1442-2042.1997.tb00315.x.Peer-Reviewed Original ResearchConceptsRat bladder smooth muscleBladder smooth muscleMuscarinic receptor subtypesSmooth muscleM3 receptorsReceptor subtypesPI hydrolysisCarbachol stimulationBladder smooth muscle contractionPhosphatidylinositol hydrolysisN-methylpiperidine methiodideRat urinary bladderSubtype-specific antagonistsSmooth muscle contractionProduction of IP3Expression of mRNAContractile responseUrinary bladderSpecific antagonistMuscle contractionBasal levelsInhibitory effectSubtypesReceptorsMuscle
1996
Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens
Saito M, Nishi K, Fukumoto Y, Weiss R, Latifpour J. Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens. Biochemical Pharmacology 1996, 52: 1593-1598. PMID: 8937475, DOI: 10.1016/s0006-2952(96)00565-5.Peer-Reviewed Original ResearchConceptsET receptorsAge-matched controlsRat vasa deferentiaIRL 1620BQ-610Vasa deferentiaET-1ET-3ETA receptor subtypeGroups of ratsDiabetic ratsExperimental diabetesEndothelin receptorsPlasma levelsReceptor subtypesInsulin treatmentPeripheral tissuesRat vasPharmacological profileReceptor characteristicsFmol/StreptozotocinReceptorsWeeksEndothelinEffect of experimental diabetes on rat prostate endothelin receptors
Saito M, Nishi K, Foster H, Weiss R, Latifpour J. Effect of experimental diabetes on rat prostate endothelin receptors. European Journal Of Pharmacology 1996, 310: 197-200. PMID: 8884217, DOI: 10.1016/0014-2999(96)00422-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightDiabetes Mellitus, ExperimentalMaleOrgan SizeProstateRatsRats, Sprague-DawleyReceptors, Endothelin
1995
Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder
Mimata H, Wheeler M, Fukumoto Y, Takigawa H, Nishimoto T, Weiss R, Latifpour J. Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder. Molecular And Cellular Biochemistry 1995, 152: 71-76. PMID: 8609914, DOI: 10.1007/bf01076465.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalHydrolysisMalePhosphatidylinositolsRatsRats, Sprague-DawleyReceptors, MuscarinicSignal TransductionUrinary BladderConceptsDiabetic bladderRat bladderAltered functional responseControl rat bladdersCarbachol-induced increaseMuscarinic receptor densityPhosphatidyl inositol hydrolysisMuscarinic agonist stimulationSucrose-fed animalsRat detrusorContractile responseInositol phosphate productionMuscarinic receptorsMuscarinic agonistsReceptor densityBladderAgonist stimulationPhosphatidylinositol metabolismInositol uptakeEC50 valuesSignal transduction pathwaysPhosphate productionTransduction pathwaysDetrusorStreptozotocin
1994
Diabetes-Induced Alterations in the Properties of Muscarinic Cholinergic Receptors in Rat Vas Deferens
Kamai T, Fukumoto Y, Gousse A, Yoshida M, Davenport T, Weiss R, Latifpour J. Diabetes-Induced Alterations in the Properties of Muscarinic Cholinergic Receptors in Rat Vas Deferens. Journal Of Urology 1994, 152: 1017-1021. PMID: 8051725, DOI: 10.1016/s0022-5347(17)32646-0.Peer-Reviewed Original ResearchConceptsMuscarinic cholinergic receptorsRat vasVas deferensCholinergic receptorsMuscarinic receptorsDiabetic insulin-treated ratsMuscarinic cholinergic receptor subtypesMuscarinic cholinergic receptor densityMembrane particulatesCholinergic receptor densityDiabetes-Induced AlterationsAF-DX 116Cholinergic receptor subtypesMuscarinic cholinergic antagonistAdministration of insulinInsulin-treated ratsAge-matched controlsRat vas deferensRank orderAdditional pharmacological studiesDiabetic ratsBladder domeCerebral cortexCholinergic antagonistsReceptor subtypesReversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors
Fukomoto Y, Yoshida M, Weiss R, Latifpour J. Reversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors. Diabetes 1994, 43: 819-826. PMID: 8194669, DOI: 10.2337/diab.43.6.819.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBody WeightCell MembraneDiabetes Mellitus, ExperimentalDiaminesDiuresisDrinking BehaviorInsulinKineticsMaleMyocardiumOrgan SizeParasympatholyticsPiperidinesPirenzepineProstateQuinuclidinyl BenzilateRatsRats, Sprague-DawleyReceptors, MuscarinicSucroseTestosteroneUp-RegulationUrinary BladderConceptsAge-matched control ratsMuscarinic receptorsRat bladder domeBladder domeDiuretic ratsDiabetic ratsControl ratsSTZ-induced diabetic ratsInsulin-treated diabetic ratsDiabetes-induced upregulationEarly insulin treatmentSucrose-fed ratsGroups of ratsIncreased water intakeBladder hypertrophyUrine outputInsulin treatmentRadioligand receptorRatsDiabetesDiuretic stateReceptorsWater intakeWeeksUpregulation
1993
The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate
Fukumoto Y, Yoshida M, Dokita S, Kamai T, Weiss R, Latifpour J. The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate. Journal Of Urology 1993, 149: 1602-1606. PMID: 8388963, DOI: 10.1016/s0022-5347(17)36459-5.Peer-Reviewed Original ResearchConceptsMuscarinic cholinergic receptorsBeta adrenergicRat prostateCholinergic receptorsInsulin treatmentMuscarinic receptorsInsulin-treated diabetic animalsEarly insulin treatmentDiabetes-induced alterationsInduction of diabetesInsulin-treated diabeticsOnset of diabetesAdministration of streptozotocinDiabetes-induced downregulationDiabetic rat prostateGroups of ratsBeta-adrenergic agonistsHigh-affinity agonistDiabetic animalsMuscarinic agonistsAdrenergic agonistsAdrenergicProstateDiabetesAgonists