2004
Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
Kang WS, Tamarkin FJ, Wheeler MA, Weiss RM. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation. Journal Of Pharmacology And Experimental Therapeutics 2004, 310: 452-458. PMID: 15082754, DOI: 10.1124/jpet.104.066506.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary cyclic GMPNitric oxide synthaseEscherichia coli lipopolysaccharideLPS treatmentNOS activityColi lipopolysaccharideNitric oxideEndothelial nitric oxide synthaseDependent NOS activityCyclic GMPInduction of inflammationPhosphorylation of eNOSBladder inflammationLPS injectionHuman eNOSENOS proteinIntraperitoneal injectionFemale miceBladder urotheliumInflammatory responseMolecule nitric oxideMouse modelInflammationENOS phosphorylation
2001
Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model
Wheeler M, Yoon J, Olsson L, Weiss R. Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model. European Journal Of Pharmacology 2001, 417: 239-248. PMID: 11334856, DOI: 10.1016/s0014-2999(01)00911-6.Peer-Reviewed Original ResearchAdministration, IntravesicalAnimalsBlotting, WesternCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDinoprostoneFemaleInflammationInjections, IntraperitonealIsoenzymesLipopolysaccharidesMembrane ProteinsNiflumic AcidNitratesNitric OxideNitric Oxide DonorsNitric Oxide SynthaseOxidantsPenicillamineProstaglandin-Endoperoxide SynthasesProtaminesRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionRNA, MessengerUp-RegulationUrinary Bladder
1999
INDUCIBLE NITRIC OXIDE SYNTHASE WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER
SWANA H, SMITH S, PERROTTA P, SAITO N, WHEELER M, WEISS R. INDUCIBLE NITRIC OXIDE SYNTHASE WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER. Journal Of Urology 1999, 161: 630-634. PMID: 9915473, DOI: 10.1016/s0022-5347(01)61985-2.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Transitional CellHumansImmunohistochemistryNitric Oxide SynthaseReverse Transcriptase Polymerase Chain ReactionUrinary Bladder NeoplasmsConceptsTransitional cell carcinomaNitric oxide synthaseInducible nitric oxide synthaseReverse transcriptase-polymerase chain reactionBladder tissueCell carcinomaInflammatory cellsNOS activityOxide synthaseNitric oxideTumor cellsGrades of TCCDistribution of iNOSImmunoreactive iNOS proteinHuman bladder tumorsTranscriptase-polymerase chain reactionIndividual tumor cellsControl bladder tissueCytostatic mediatorsINOS antibodyTumor immunoreactivityWestern blot analysisBladder tumorsTumor gradeImmune stimulationInduction of Nitric Oxide Synthase with Urinary Tract Infections
Wheeler M, Smith S, Weiss R. Induction of Nitric Oxide Synthase with Urinary Tract Infections. Advances In Experimental Medicine And Biology 1999, 462: 359-369. PMID: 10599439, DOI: 10.1007/978-1-4615-4737-2_28.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnzyme InductionHumansInflammationNitric Oxide SynthaseNitric Oxide Synthase Type IIUrinary BladderUrinary Tract InfectionsConceptsNitric oxide synthaseOxide synthaseNitric oxideEnzyme nitric oxide synthaseUrinary tract infectionCyclic GMPNon-cholinergic neuronsGuanylyl cyclase enzymeTract infectionsL-arginineL-citrullineCyclase enzymeSecond messengerMammalian tissuesSynthaseFunctional responseNeutrophilsInfectionGMPMacrophagesNeurons
1998
Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note
Smith S, Wheeler M, Weiss R. Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note. Kidney International 1998, 54: 1331-1336. PMID: 9767552, DOI: 10.1046/j.1523-1755.1998.00102.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNitric oxide synthaseNegative predictive accuracyDismutase/catalaseNitrite dipstickTract infectionsPresence of UTINOS cofactorUrine pelletsInducible nitric oxide synthaseHigh negative predictive accuracyHigh positive predictive accuracyUrine screening testsUrine culture resultsNBT reductionInducible NOS activityLeukocyte esterase dipstickNitroblue tetrazolium reductionPositive predictive accuracyNOS inhibitorNOS activityOxide synthaseEarly predictorCulture resultsScreening testBladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder.
Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 1203-8. PMID: 9495884.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary tract infectionIntravesical instillationLocalized inflammatory responseInflammatory responseRat bladderSystemic bacterial lipopolysaccharideInstillation of lipopolysaccharideRat urinary bladderNitric oxide synthaseIL-6 mRNATract infectionsBladder instillationIL-10Urinary nitrateRegulate cytokinesINOS activityIntraperitoneal injectionNOS activityOxide synthaseUrinary bladderImportance of lipopolysaccharideINOS proteinInstillationCGMP levels
1997
EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITIS
Wheeler M, Smith S, Saito N, Foster H, Weiss R. EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITIS. Journal Of Urology 1997, 158: 2045-2050. PMID: 9366309, DOI: 10.1016/s0022-5347(01)68150-3.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralArginineCyclic GMPCystitis, InterstitialFemaleHumansNitratesNitric Oxide SynthaseNitritesTime FactorsConceptsInterstitial cystitis patientsNitric oxide synthase activityOral L-arginineOxide synthase activityInterstitial cystitisCystitis patientsL-arginineIL-8Oral L-arginine treatmentLong-term oral administrationInducible nitric oxide synthase (iNOS) proteinNitric oxideNitric oxide synthase proteinCyclic guanosine monophosphate levelsNitric oxide synthase pathwayUrinary nitric oxideInterstitial cystitis symptomsL-arginine treatmentInterleukin-8 levelsCytokine IL-8Nitric oxide synthaseSmooth muscle relaxationUrine of patientsGuanosine monophosphate levelsOxide synthase pathwayBacterial infection induces nitric oxide synthase in human neutrophils.
Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. Journal Of Clinical Investigation 1997, 99: 110-116. PMID: 9011564, PMCID: PMC507774, DOI: 10.1172/jci119121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsArginineBacterial InfectionsBlotting, WesternCanavanineCell MembraneCitrullineFemaleGuanidinesHumansImmunohistochemistryIsoenzymesLeukocyte Common AntigensMaleMiddle AgedNeutrophilsNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitroarginineOmega-N-MethylarginineOrnithinePolymerase Chain ReactionRNA, MessengerSulfonamidesThioureaTrifluoperazineUrinary Tract InfectionsConceptsInducible nitric oxide synthaseUrinary tract infectionNitric oxide synthaseNitric oxide synthase activityTract infectionsOxide synthase activityOxide synthaseInducible nitric oxide synthase activityNitric oxide synthase proteinNitric oxide synthase isoformsInduces nitric oxide synthaseMajor nitric oxide synthase isoformHuman inflammatory cellsHuman inducible nitric oxide synthaseExtended elevationInflammatory cellsProinflammatory functionsAntibiotic treatmentInflammatory processSynthase activityImmunocytochemical evidenceHuman neutrophilsInfectionCalcium independentSynthase isoforms
1996
Nitric oxide synthase induction with renal transplant rejection or infection
Smith S, Wheeler M, Zhang R, Weiss E, Lorber M, Sessa W, Weiss R. Nitric oxide synthase induction with renal transplant rejection or infection. Kidney International 1996, 50: 2088-2093. PMID: 8943494, DOI: 10.1038/ki.1996.533.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRenal transplant patientsNitric oxide synthaseCyclic GMP levelsTransplant patientsTract infectionsNOS activityPost-renal transplantation patientsGMP levelsInducible nitric oxide synthaseNitric oxideRenal allograft rejectionRenal transplant rejectionNitric oxide synthase inductionInducible NOS (iNOS) mRNAUrine of patientsRenal transplantationTransplantation patientsAllograft rejectionTransplant rejectionInducible NOSOxide synthaseNOS mRNAPatientsSynthase inductionUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMP
1994
Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation
Dokita S, Smith S, Nishimoto T, Wheeler M, Weiss R. Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation. European Journal Of Pharmacology 1994, 266: 269-275. PMID: 7513645, DOI: 10.1016/0922-4106(94)90136-8.Peer-Reviewed Original ResearchConceptsNitric oxide synthase activityTransmural nerve stimulationOxide synthase activityRabbit urethraNerve stimulationNOS activityL-arginineSoluble nitric oxide synthaseNitric oxide synthase inhibitorRelaxation responseNitric oxideCyclic GMPOxide synthase inhibitorNitric oxide synthaseCyclic GMP levelsUrethral relaxationNG-nitroRank orderOxide synthaseSynthase activityNG-methylSynthase inhibitorElectrical stimulationUrethraSame rank orderNitric oxide synthase: An endogenous source of elevated nitrite in infected urine
Smith S, Wheeler M, Weiss R. Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine. Kidney International 1994, 45: 586-591. PMID: 7513034, DOI: 10.1038/ki.1994.76.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNon-infected urineTract infectionsL-arginineUrine nitriteInfected urineUrinary nitric oxide synthase activityNitric oxide synthase activityUrinary nitrite levelsEndogenous sourcesOxide synthase activitySynthase activityMin/Exogenous L-arginineNG-nitroNG-monomethylGriess methodParticulate fractionNitrite levelsUrine fractionsEndogenous productionNitrite productionUrineInfectionElevated nitrite