2008
Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats
Yono M, Mane SM, Lin A, Weiss RM, Latifpour J. Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats. Life Sciences 2008, 83: 192-197. PMID: 18619471, DOI: 10.1016/j.lfs.2008.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Gene Expression ProfilingInsulinMaleProstateRatsRats, Inbred BBReverse Transcriptase Polymerase Chain ReactionStreptozocinConceptsProstate growthMRNA expression levelsBio-BreedingDiabetic groupExpression levelsVentral prostateSTZ-diabetic ratsReal-time reverse transcription-polymerase chain reactionSTZ-induced diabeticReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMicroarray analysisHyperglycemic diabetes
2004
Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens
Yono M, Latifpour J, Takahashi W, Pouresmail M, Afiatpour P, Weiss RM. Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens. Journal Of Receptors And Signal Transduction 2004, 24: 53-66. PMID: 15344879, DOI: 10.1081/rrs-120034106.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAspartic Acid EndopeptidasesDNA PrimersDown-RegulationEndothelin-1Endothelin-3Endothelin-Converting EnzymesKineticsMaleMetalloendopeptidasesPolymerase Chain ReactionProtein BindingRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerVas DeferensConceptsEndothelin receptor systemET receptor systemAge-related changesWeek old ratsET receptorsMonth old ratsOld ratsET-1Receptor systemVas deferensReceptor subtypesRat vasET-3MRNA levelsAge groupsFunctional ET receptorsTotal ET receptorsReceptor subtype mRNAsReal-time reverse transcription-polymerase chain reactionRadioligand receptor bindingReverse transcription-polymerase chain reactionPredominant mRNA expressionRat vas deferensTranscription-polymerase chain reactionRadioligand receptor binding assays
2003
Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle
Takahashi W, Yono M, Wada Y, Ikeda K, Weiss R, Latifpour J. Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle. BJU International 2003, 92: 803-809. PMID: 14616470, DOI: 10.1046/j.1464-410x.2003.04466.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesAutoradiographyCastrationEndothelin-Converting EnzymesEndothelinsMaleMetalloendopeptidasesRatsRats, Sprague-DawleyReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionSeminal VesiclesConceptsExpression of endothelinETB receptor subtypesET receptorsECE-1 mRNARat seminal vesicleReceptor subtypesSeminal vesiclesET-1Slide-mounted frozen sectionsET receptor systemET-3 mRNATotal ET receptorsETA receptor subtypeSprague-Dawley ratsReverse transcription-polymerase chain reactionExpression levelsExpression of ETAEffects of castrationEndothelin-converting enzymeMultiplex reverse transcription-polymerase chain reactionPolymerase chain reactionSmooth muscleET-3Autoradiographic studyFrozen sectionsDevelopmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
Afiatpour P, Latifpour J, Takahashi W, Yono M, Foster HE, Ikeda K, Pouresmail M, Weiss RM. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 2003, 367: 462-472. PMID: 12700883, DOI: 10.1007/s00210-003-0715-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyBinding SitesEndothelin-1Gene ExpressionIodine RadioisotopesMuscle ContractionMuscle, SmoothRadioligand AssayRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsUrinary BladderConceptsETA receptor subtypeSmooth muscle layerReceptor subtypesRat detrusorEndothelin receptorsET receptorsET-1Muscle layerSelective ETA receptor antagonistET receptor systemLarger contractile responsesTotal ET receptorsReceptor subtype mRNAsETA receptor antagonistETB receptor subtypesReal-time reverse transcription-polymerase chain reactionMuscle bath techniqueBladder smooth muscleReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAge-dependent decreaseAge-dependent alterationsReal-time RT-PCRContractile responseSubtype mRNAs
2002
Quantification of endothelins, their receptors, and endothelin-converting enzyme mRNA in rat genitourinary tract using real-time RT-PCR
Yono M, Takahashi W, Pouresmail M, Johnson DR, Foster HE, Weiss RM, Latifpour J. Quantification of endothelins, their receptors, and endothelin-converting enzyme mRNA in rat genitourinary tract using real-time RT-PCR. Journal Of Pharmacological And Toxicological Methods 2002, 48: 87-95. PMID: 14565565, DOI: 10.1016/s1056-8719(03)00022-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesDNA PrimersEndothelin-Converting EnzymesEndothelinsIn Vitro TechniquesMaleMetalloendopeptidasesRatsRats, Inbred F344Receptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerUrogenital SystemConceptsRat genitourinary tractGenitourinary tractET-1MRNA expressionET-3Receptor subtype mRNA expressionReceptor subtype mRNAsETA receptor subtypeReal-time reverse transcription-polymerase chain reactionSubtype mRNA expressionReverse transcription-polymerase chain reactionReceptor-mediated mechanismTranscription-polymerase chain reactionReal-time RT-PCRSubtype mRNAsPolymerase chain reactionReceptor subtypesRat bladderReal-time PCRDorsolateral prostateReceptor mRNAVentral prostateECE-1Computer-assisted programVas deferensThe effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate
Takahashi W, Afiatpour P, Foster H, Ikeda K, Wada Y, Weiss RM, Latifpour J. The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate. Naunyn-Schmiedeberg's Archives Of Pharmacology 2002, 366: 166-176. PMID: 12122504, DOI: 10.1007/s00210-002-0575-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesAutoradiographyDiabetes Mellitus, ExperimentalDNA PrimersEndothelin-1Endothelin-3Endothelin-Converting EnzymesGene ExpressionMaleMetalloendopeptidasesMicroscopyOrchiectomyOrgan SizeProstateProtein BindingRadioligand AssayRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsReceptor subtype mRNAsET receptor subtypesSerum testosterone levelsET receptorsRat prostateEffects of castrationReceptor subtypesSubtype mRNAsDorsolateral regionTestosterone levelsET-1Three-month-old SpraguePharmacological propertiesDiabetes-induced reductionET receptor systemET-3 mRNAETB receptor subtypesPost-operative dayReverse transcription-polymerase chain reactionVentral regionECE-1 mRNATranscription-polymerase chain reactionLight microscopy autoradiographyEnzyme-1 mRNAMultiplex reverse transcription-polymerase chain reaction
2001
Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model
Wheeler M, Yoon J, Olsson L, Weiss R. Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model. European Journal Of Pharmacology 2001, 417: 239-248. PMID: 11334856, DOI: 10.1016/s0014-2999(01)00911-6.Peer-Reviewed Original ResearchAdministration, IntravesicalAnimalsBlotting, WesternCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDinoprostoneFemaleInflammationInjections, IntraperitonealIsoenzymesLipopolysaccharidesMembrane ProteinsNiflumic AcidNitratesNitric OxideNitric Oxide DonorsNitric Oxide SynthaseOxidantsPenicillamineProstaglandin-Endoperoxide SynthasesProtaminesRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionRNA, MessengerUp-RegulationUrinary BladderUrine Detection of Survivin and Diagnosis of Bladder Cancer
Smith SD, Wheeler MA, Plescia J, Colberg JW, Weiss RM, Altieri DC. Urine Detection of Survivin and Diagnosis of Bladder Cancer. JAMA 2001, 285: 324-328. PMID: 11176843, DOI: 10.1001/jama.285.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorBlotting, WesternFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalPrognosisProteinsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityStatistics, NonparametricSurvivinUrinary Bladder NeoplasmsUrogenital NeoplasmsUrologic DiseasesConceptsRecurrent bladder cancerUrinary tract diseaseBladder cancerUrine samplesTract diseaseHealthy volunteersSurvivin levelsProstate-specific antigen levelLow-grade bladder cancerPrognostic molecular markersNoninvasive diagnostic testTranscriptase-polymerase chain reactionCommon human cancersUrine survivinGenitourinary cancersProgression of cancerAggressive diseaseAntigen levelsCervical cancerUrology clinicPolymerase chain reactionUnfavorable outcomeCystoscopy resultsRT-PCR methodSurvivin detectionRegulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland
Ikeda K, Wada Y, Sanematsu H, Foster HE, Shin D, Weiss RM, Latifpour J. Regulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland. Journal Of Endocrinology 2001, 168: 163-175. PMID: 11139780, DOI: 10.1677/joe.0.1680163.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAnimalsAutoradiographyBinding, CompetitiveDiabetes Mellitus, ExperimentalEndothelin-1Endothelin-3Gene ExpressionMaleProtein BindingRatsRats, Sprague-DawleyReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsEndothelin-converting enzyme-1Rat adrenal glandET receptor subtypesInduction of diabetesAdrenal glandReceptor subtypesETB receptorsExperimental diabetesAge-matched control ratsECE-1 mRNA levelsET-3 mRNAPredominant receptor subtypeDiabetes-induced changesEndothelin receptor subtypesInsulin-treated diabeticsSecretion of steroidsReceptor subtypes ETARadioligand receptor bindingAdrenal gland sizeET-1 mRNAExpression levelsRegulatory effectsVascular toneET receptorsEndothelin action
2000
Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment
Saito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalEndothelin Receptor AntagonistsEndothelin-1InsulinIodine RadioisotopesMaleOrgan SizeProstateProtein IsoformsRadioligand AssayRandom AllocationRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneUp-RegulationConceptsInduction of diabetesET receptorsReverse transcription-polymerase chain reactionRat prostateInsulin treatmentDiabetic animalsReceptor subtypesDiabetes-induced upregulationET receptor densityEndothelin receptor subtypesET receptor subtypesSTZ-injected ratsSerum testosterone levelsRadioligand receptor bindingDiabetic rat prostateTranscription-polymerase chain reactionDiabetic ratsETB receptorsSmaller prostatesEndothelin receptorsProstatic stromaTestosterone levelsReceptor densityPharmacological profileAutoradiographic study
1999
INDUCIBLE NITRIC OXIDE SYNTHASE WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER
SWANA H, SMITH S, PERROTTA P, SAITO N, WHEELER M, WEISS R. INDUCIBLE NITRIC OXIDE SYNTHASE WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER. Journal Of Urology 1999, 161: 630-634. PMID: 9915473, DOI: 10.1016/s0022-5347(01)61985-2.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Transitional CellHumansImmunohistochemistryNitric Oxide SynthaseReverse Transcriptase Polymerase Chain ReactionUrinary Bladder NeoplasmsConceptsTransitional cell carcinomaNitric oxide synthaseInducible nitric oxide synthaseReverse transcriptase-polymerase chain reactionBladder tissueCell carcinomaInflammatory cellsNOS activityOxide synthaseNitric oxideTumor cellsGrades of TCCDistribution of iNOSImmunoreactive iNOS proteinHuman bladder tumorsTranscriptase-polymerase chain reactionIndividual tumor cellsControl bladder tissueCytostatic mediatorsINOS antibodyTumor immunoreactivityWestern blot analysisBladder tumorsTumor gradeImmune stimulation