2004
Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
Kang WS, Tamarkin FJ, Wheeler MA, Weiss RM. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation. Journal Of Pharmacology And Experimental Therapeutics 2004, 310: 452-458. PMID: 15082754, DOI: 10.1124/jpet.104.066506.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCystitisDisease Models, AnimalEscherichia coliFemaleLipopolysaccharidesMiceMice, Inbred C57BLNitric Oxide SynthaseNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIUp-RegulationConceptsInducible nitric oxide synthaseUrinary cyclic GMPNitric oxide synthaseEscherichia coli lipopolysaccharideLPS treatmentNOS activityColi lipopolysaccharideNitric oxideEndothelial nitric oxide synthaseDependent NOS activityCyclic GMPInduction of inflammationPhosphorylation of eNOSBladder inflammationLPS injectionHuman eNOSENOS proteinIntraperitoneal injectionFemale miceBladder urotheliumInflammatory responseMolecule nitric oxideMouse modelInflammationENOS phosphorylation
1999
Induction of Nitric Oxide Synthase with Urinary Tract Infections
Wheeler M, Smith S, Weiss R. Induction of Nitric Oxide Synthase with Urinary Tract Infections. Advances In Experimental Medicine And Biology 1999, 462: 359-369. PMID: 10599439, DOI: 10.1007/978-1-4615-4737-2_28.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnzyme InductionHumansInflammationNitric Oxide SynthaseNitric Oxide Synthase Type IIUrinary BladderUrinary Tract InfectionsConceptsNitric oxide synthaseOxide synthaseNitric oxideEnzyme nitric oxide synthaseUrinary tract infectionCyclic GMPNon-cholinergic neuronsGuanylyl cyclase enzymeTract infectionsL-arginineL-citrullineCyclase enzymeSecond messengerMammalian tissuesSynthaseFunctional responseNeutrophilsInfectionGMPMacrophagesNeurons
1998
Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note
Smith S, Wheeler M, Weiss R. Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note. Kidney International 1998, 54: 1331-1336. PMID: 9767552, DOI: 10.1046/j.1523-1755.1998.00102.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNitric oxide synthaseNegative predictive accuracyDismutase/catalaseNitrite dipstickTract infectionsPresence of UTINOS cofactorUrine pelletsInducible nitric oxide synthaseHigh negative predictive accuracyHigh positive predictive accuracyUrine screening testsUrine culture resultsNBT reductionInducible NOS activityLeukocyte esterase dipstickNitroblue tetrazolium reductionPositive predictive accuracyNOS inhibitorNOS activityOxide synthaseEarly predictorCulture resultsScreening testBladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder.
Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 1203-8. PMID: 9495884.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary tract infectionIntravesical instillationLocalized inflammatory responseInflammatory responseRat bladderSystemic bacterial lipopolysaccharideInstillation of lipopolysaccharideRat urinary bladderNitric oxide synthaseIL-6 mRNATract infectionsBladder instillationIL-10Urinary nitrateRegulate cytokinesINOS activityIntraperitoneal injectionNOS activityOxide synthaseUrinary bladderImportance of lipopolysaccharideINOS proteinInstillationCGMP levels