2005
Regulation of cyclic nucleotides in the urinary tract
Wheeler MA, Ayyagari RR, Wheeler GL, Weiss RM. Regulation of cyclic nucleotides in the urinary tract. Journal Of Smooth Muscle Research 2005, 41: 1. PMID: 15855736, DOI: 10.1540/jsmr.41.1.Peer-Reviewed Original ResearchConceptsUrinary tractRelaxation responseLow compliance bladderSmooth muscle functionG proteinsCyclic AMP productionStimulatory G proteinCyclic nucleotide levelsG protein isoformsUrge incontinenceTreatment optionsProstate cancerMuscle functionDisease processFamily of phosphodiesterasesSpecific PDE inhibitorsAMP productionPDE inhibitorsBladderAdenylyl cyclasePDE isoformsTractPharmacological potentialCancerPDE expression
2000
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Derweesh I, Wheeler M, Weiss R. Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 969-74. PMID: 10945848.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAdenylate Cyclase ToxinAdenylyl CyclasesAdrenergic beta-AgonistsAgingAnimalsBlotting, WesternCarbazolesColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsGTP-Binding ProteinsIndolesIsoproterenolMuscle, SmoothPertussis ToxinPyrrolesRatsReceptors, Adrenergic, betaUrinary BladderVirulence Factors, BordetellaConceptsPertussis toxin-catalyzed ADP-ribosylationToxin-catalyzed ADP-ribosylationRat bladderPertussis toxin-sensitive G proteinToxin-sensitive G proteinResponses of bladdersRat urinary bladderAdenylyl cyclaseTreatment of bladderBeta-adrenergic stimulationADP-ribosylationG proteinsAdenylyl cyclase activityResponsive adenylyl cyclaseAge-dependent declineWestern blot analysisG-protein contentUrinary bladderPertussis toxinBladderIsoproterenol stimulationRelaxation responseCyclase activityFunctional activityBlot analysis
1997
Neurokinin Induced Inositol Phosphate Production in Guinea Pig Bladder
Martin T, Wheeler M, Weiss R. Neurokinin Induced Inositol Phosphate Production in Guinea Pig Bladder. Journal Of Urology 1997, 157: 1098-1102. PMID: 9072551, DOI: 10.1016/s0022-5347(01)65149-8.Peer-Reviewed Original ResearchConceptsGuinea pig bladder
1990
Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders.
Wheeler M, Pontari M, Nishimoto T, Weiss R. Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 277-83. PMID: 2366184.Peer-Reviewed Original Research
1986
Age dependence of adenylate cyclase in guinea pig ureter homogenate.
Wheeler M, Housman A, Cho Y, Weiss R. Age dependence of adenylate cyclase in guinea pig ureter homogenate. Journal Of Pharmacology And Experimental Therapeutics 1986, 239: 99-103. PMID: 3761201.Peer-Reviewed Original ResearchRelaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP
Morita T, Wheeler M, Weiss R. Relaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP. Journal Of Urology 1986, 135: 1293-1295. PMID: 3012124, DOI: 10.1016/s0022-5347(17)46077-0.Peer-Reviewed Original ResearchConceptsDetrusor muscleRelaxant effectRabbit detrusor muscle stripsDetrusor muscle relaxationDetrusor muscle stripsRabbit detrusor muscleConcentration-dependent relaxationDetrusor smooth muscleRabbit detrusor smooth muscleBeta-adrenergic antagonistsBeta-adrenergic receptorsCyclic AMPCyclic AMP levelsAdenylate cyclase inhibitorRabbit detrusorMuscle stripsMuscle relaxationSmooth muscleCyclase inhibitorPhosphodiesterase inhibitorRelaxation responseAMP levelsAdenylate cyclaseDependent relaxationForskolin