2005
Regulation of cyclic nucleotides in the urinary tract
Wheeler MA, Ayyagari RR, Wheeler GL, Weiss RM. Regulation of cyclic nucleotides in the urinary tract. Journal Of Smooth Muscle Research 2005, 41: 1. PMID: 15855736, DOI: 10.1540/jsmr.41.1.Peer-Reviewed Original ResearchConceptsUrinary tractRelaxation responseLow compliance bladderSmooth muscle functionG proteinsCyclic AMP productionStimulatory G proteinCyclic nucleotide levelsG protein isoformsUrge incontinenceTreatment optionsProstate cancerMuscle functionDisease processFamily of phosphodiesterasesSpecific PDE inhibitorsAMP productionPDE inhibitorsBladderAdenylyl cyclasePDE isoformsTractPharmacological potentialCancerPDE expression
2004
Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens
Yono M, Latifpour J, Takahashi W, Pouresmail M, Afiatpour P, Weiss RM. Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens. Journal Of Receptors And Signal Transduction 2004, 24: 53-66. PMID: 15344879, DOI: 10.1081/rrs-120034106.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAspartic Acid EndopeptidasesDNA PrimersDown-RegulationEndothelin-1Endothelin-3Endothelin-Converting EnzymesKineticsMaleMetalloendopeptidasesPolymerase Chain ReactionProtein BindingRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerVas DeferensConceptsEndothelin receptor systemET receptor systemAge-related changesWeek old ratsET receptorsMonth old ratsOld ratsET-1Receptor systemVas deferensReceptor subtypesRat vasET-3MRNA levelsAge groupsFunctional ET receptorsTotal ET receptorsReceptor subtype mRNAsReal-time reverse transcription-polymerase chain reactionRadioligand receptor bindingReverse transcription-polymerase chain reactionPredominant mRNA expressionRat vas deferensTranscription-polymerase chain reactionRadioligand receptor binding assays
2003
Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
Afiatpour P, Latifpour J, Takahashi W, Yono M, Foster HE, Ikeda K, Pouresmail M, Weiss RM. Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 2003, 367: 462-472. PMID: 12700883, DOI: 10.1007/s00210-003-0715-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyBinding SitesEndothelin-1Gene ExpressionIodine RadioisotopesMuscle ContractionMuscle, SmoothRadioligand AssayRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsUrinary BladderConceptsETA receptor subtypeSmooth muscle layerReceptor subtypesRat detrusorEndothelin receptorsET receptorsET-1Muscle layerSelective ETA receptor antagonistET receptor systemLarger contractile responsesTotal ET receptorsReceptor subtype mRNAsETA receptor antagonistETB receptor subtypesReal-time reverse transcription-polymerase chain reactionMuscle bath techniqueBladder smooth muscleReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAge-dependent decreaseAge-dependent alterationsReal-time RT-PCRContractile responseSubtype mRNAs
2001
Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis
Wada Y, Latifpour J, Saito M, Afiatpour P, Weiss R. Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis. BJU International 2001, 88: 950-959. PMID: 11851620, DOI: 10.1046/j.1464-4096.2001.2441.x.Peer-Reviewed Original ResearchConceptsRabbit renal pelvisTotal ET receptorsETA receptor subtypeRenal pelvisET receptorsET-1Age groupsContractile responseEndothelin receptorsPelvic regionReceptor subtypesSpontaneous activityET-1-induced contractile responseOld rabbitsDensities of ETAYoung rabbitsPresence of ETASubtype-selective compoundsReceptor-binding techniquesConcentration-dependent mannerETB subtypeEffect of ageETA receptorsETB receptorsMuscle strips
2000
AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. PMID: 10953160, DOI: 10.1097/00005392-200009010-00054.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile responseAlterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Derweesh I, Wheeler M, Weiss R. Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 969-74. PMID: 10945848.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAdenylate Cyclase ToxinAdenylyl CyclasesAdrenergic beta-AgonistsAgingAnimalsBlotting, WesternCarbazolesColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsGTP-Binding ProteinsIndolesIsoproterenolMuscle, SmoothPertussis ToxinPyrrolesRatsReceptors, Adrenergic, betaUrinary BladderVirulence Factors, BordetellaConceptsPertussis toxin-catalyzed ADP-ribosylationToxin-catalyzed ADP-ribosylationRat bladderPertussis toxin-sensitive G proteinToxin-sensitive G proteinResponses of bladdersRat urinary bladderAdenylyl cyclaseTreatment of bladderBeta-adrenergic stimulationADP-ribosylationG proteinsAdenylyl cyclase activityResponsive adenylyl cyclaseAge-dependent declineWestern blot analysisG-protein contentUrinary bladderPertussis toxinBladderIsoproterenol stimulationRelaxation responseCyclase activityFunctional activityBlot analysisAGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. DOI: 10.1016/s0022-5347(05)67319-3.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile response
1999
Developmental aspects of endothelin receptors in rabbit lower urinary tract
Saito M, Latifpour J, Weiss R. Developmental aspects of endothelin receptors in rabbit lower urinary tract. Neurourology And Urodynamics 1999, 19: 71-85. PMID: 10602249, DOI: 10.1002/(sici)1520-6777(2000)19:1<71::aid-nau8>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsLower urinary tractRabbit lower urinary tractEndothelin receptorsUrinary tractBladder baseBladder domeMale rabbitsEndothelin receptor subtypesAge-related alterationsOld male rabbitsET receptorsReceptor subtypesPharmacological characterizationPharmacological profileAged rabbitsSubtype specificityReceptorsTractDevelopment-related changesSimilar proportionsWeeksReceptor compoundsUrethraRabbitsRank order
1997
Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle
Wheeler M, Pontari M, Dokita S, Nishimoto T, Cho Y, Hong K, Weiss R. Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle. Molecular And Cellular Biochemistry 1997, 169: 115-124. PMID: 9089638, DOI: 10.1023/a:1006823611864.Peer-Reviewed Original ResearchConceptsSoluble guanylyl cyclase activityAdult guinea pigsGuanylyl cyclase activityCyclase activityBladder domeSodium nitroprussideGuinea pigsUrinary tract smooth muscleGuanylyl cyclaseAtrial natriuretic factorParticulate guanylyl cyclaseAge-dependent changesAge-specific differencesUrinary tractNatriuretic factorSmooth muscleUreterUrethraRelaxation responseBladderInduced activationNitroprussideTissueRank orderAge
1995
Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705. PMID: 7715014, DOI: 10.1016/s0022-5347(01)67508-6.Peer-Reviewed Original ResearchConceptsElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsBladder detrusor
1993
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract
Yoshida M, Latifpour J, Weiss R. Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract. European Journal Of Pharmacology 1993, 232: 159-167. PMID: 8385616, DOI: 10.1016/0014-2999(93)90769-e.Peer-Reviewed Original ResearchConceptsLower urinary tractBladder baseBladder domeUrinary tractChannel antagonistsRabbit lower urinary tractBay K 8644Channel antagonist receptorsAge-dependent changesDensity of Ca2Age-related changesAntagonist binding sitesReceptor densityPharmacological profileAntagonist receptorsRabbit urethraUrethraAge groupsBmax valuesDays rabbitsAntagonistTractWeeksRank orderBinding sites
1992
Age-related changes in calcium antagonist receptors in rabbit ureter.
Yoshida M, Latifpour J, Weiss R. Age-related changes in calcium antagonist receptors in rabbit ureter. Neonatology 1992, 18: 100-7. PMID: 1483355, DOI: 10.1159/000480603.Peer-Reviewed Original Research
1991
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra.
Yoshida M, Latifpour J, Nishimoto T, Weiss R. Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 1100-8. PMID: 1675287.Peer-Reviewed Original ResearchConceptsConcentration-response curvesFemale rabbit urethraContractile responseAdrenergic receptorsRabbit urethraAge groupsAlpha-2 adrenergic receptorsED50 valuesEmax valuesConcentration-dependent contractionsMaximum contractile responsePhenylephrine-induced contractionAlpha-adrenergic receptorsAlpha 1B subtypeMuscle bath techniqueYounger age groupsAge-dependent differencesPharmacological characterizationClonidinePharmacological characteristicsOxymetazolinePhenylephrineNorepinephrineFree bufferAlpha 1
1990
Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders.
Wheeler M, Pontari M, Nishimoto T, Weiss R. Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 277-83. PMID: 2366184.Peer-Reviewed Original ResearchAutonomic receptors in urinary tract: sex and age differences.
Latifpour J, Kondo S, O'Hollaren B, Morita T, Weiss R. Autonomic receptors in urinary tract: sex and age differences. Journal Of Pharmacology And Experimental Therapeutics 1990, 253: 661-7. PMID: 2338651.Peer-Reviewed Original ResearchConceptsAlpha-2 adrenergic receptorsBladder domeBladder baseBeta-adrenergic receptorsAdrenergic receptorsCholinergic receptorsMuscarinic receptorsUrinary tractAlpha-2 adrenergic receptor densityLower urinary tract smooth muscleUrinary tract smooth muscleRabbit bladder baseAlpha 2A subtypeMuscarinic cholinergic receptorsAdrenergic receptor densityLower urinary tractSelective adrenergic agonistsAdult rat cortexNeonatal rat lungBeta-2 adrenergic receptorsAutonomic receptorsAge-related differencesRat cortexAdrenergic agonistsMale urethra
1988
Ontogeny of Cyclic AMP and Cyclic GMP Phosphodiesterase Activities and of Calmodulin Levels in Guinea Pig Ureter
Cho Y, Wheeler M, Weiss R. Ontogeny of Cyclic AMP and Cyclic GMP Phosphodiesterase Activities and of Calmodulin Levels in Guinea Pig Ureter. Journal Of Urology 1988, 139: 1095-1098. PMID: 2834569, DOI: 10.1016/s0022-5347(17)42794-7.Peer-Reviewed Original Research
1987
Age-Related Changes in Contractile Force of Rabbit Detrusor Muscle to Prostaglandin E1, E2 and F2α
Morita T, Wheeler M, Weiss R. Age-Related Changes in Contractile Force of Rabbit Detrusor Muscle to Prostaglandin E1, E2 and F2α. Urologia Internationalis 1987, 42: 44-48. PMID: 3473790, DOI: 10.1159/000281848.Peer-Reviewed Original Research
1986
Age dependence of adenylate cyclase in guinea pig ureter homogenate.
Wheeler M, Housman A, Cho Y, Weiss R. Age dependence of adenylate cyclase in guinea pig ureter homogenate. Journal Of Pharmacology And Experimental Therapeutics 1986, 239: 99-103. PMID: 3761201.Peer-Reviewed Original Research
1984
Force-Velocity Relationships of Guinea Pig Ureter
Biancani P, Onyski J, Zabinski M, Weiss R. Force-Velocity Relationships of Guinea Pig Ureter. Journal Of Urology 1984, 131: 988-991. PMID: 6708244, DOI: 10.1016/s0022-5347(17)50745-4.Peer-Reviewed Original Research
1979
Clinical Implications of Ureteral Physiology
Weiss R. Clinical Implications of Ureteral Physiology. Journal Of Urology 1979, 121: 401-413. PMID: 374751, DOI: 10.1016/s0022-5347(17)56799-3.Peer-Reviewed Original Research