2000
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients
Smith S, Wheeler M, Lorber M, Weiss R. Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients. Kidney International 2000, 58: 829-837. PMID: 10916108, DOI: 10.1046/j.1523-1755.2000.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultCreatinineCyclic GMPCytokinesFemaleFollow-Up StudiesGraft RejectionHumansInterleukin-10Interleukin-2Interleukin-6Interleukin-8Kidney Failure, ChronicKidney TransplantationMaleMiddle AgedNitratesNitric OxideNitritesPredictive Value of TestsTime FactorsTumor Necrosis Factor-alphaUrinary Tract InfectionsConceptsUrinary tract infectionRenal transplant patientsAcute rejectionTransplant patientsCyclic GMPIL-2Nitric oxideNitric oxide synthase activityAdditional urine specimensUrine cytokine levelsUrine nitrate levelsNitric oxide productsMonths of transplantationOxide synthase activityUrine nitrateSoluble interleukinCytokine levelsTract infectionsIL-10IL-6IL-8Tumor necrosisUrine specimensPatientsClinical diagnosis
1998
Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder.
Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 1203-8. PMID: 9495884.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary tract infectionIntravesical instillationLocalized inflammatory responseInflammatory responseRat bladderSystemic bacterial lipopolysaccharideInstillation of lipopolysaccharideRat urinary bladderNitric oxide synthaseIL-6 mRNATract infectionsBladder instillationIL-10Urinary nitrateRegulate cytokinesINOS activityIntraperitoneal injectionNOS activityOxide synthaseUrinary bladderImportance of lipopolysaccharideINOS proteinInstillationCGMP levels
1997
EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITIS
Wheeler M, Smith S, Saito N, Foster H, Weiss R. EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITIS. Journal Of Urology 1997, 158: 2045-2050. PMID: 9366309, DOI: 10.1016/s0022-5347(01)68150-3.Peer-Reviewed Original ResearchConceptsInterstitial cystitis patientsNitric oxide synthase activityOral L-arginineOxide synthase activityInterstitial cystitisCystitis patientsL-arginineIL-8Oral L-arginine treatmentLong-term oral administrationInducible nitric oxide synthase (iNOS) proteinNitric oxideNitric oxide synthase proteinCyclic guanosine monophosphate levelsNitric oxide synthase pathwayUrinary nitric oxideInterstitial cystitis symptomsL-arginine treatmentInterleukin-8 levelsCytokine IL-8Nitric oxide synthaseSmooth muscle relaxationUrine of patientsGuanosine monophosphate levelsOxide synthase pathwayAge-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle
Wheeler M, Pontari M, Dokita S, Nishimoto T, Cho Y, Hong K, Weiss R. Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle. Molecular And Cellular Biochemistry 1997, 169: 115-124. PMID: 9089638, DOI: 10.1023/a:1006823611864.Peer-Reviewed Original ResearchConceptsSoluble guanylyl cyclase activityAdult guinea pigsGuanylyl cyclase activityCyclase activityBladder domeSodium nitroprussideGuinea pigsUrinary tract smooth muscleGuanylyl cyclaseAtrial natriuretic factorParticulate guanylyl cyclaseAge-dependent changesAge-specific differencesUrinary tractNatriuretic factorSmooth muscleUreterUrethraRelaxation responseBladderInduced activationNitroprussideTissueRank orderAge
1996
Nitric oxide synthase induction with renal transplant rejection or infection
Smith S, Wheeler M, Zhang R, Weiss E, Lorber M, Sessa W, Weiss R. Nitric oxide synthase induction with renal transplant rejection or infection. Kidney International 1996, 50: 2088-2093. PMID: 8943494, DOI: 10.1038/ki.1996.533.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRenal transplant patientsNitric oxide synthaseCyclic GMP levelsTransplant patientsTract infectionsNOS activityPost-renal transplantation patientsGMP levelsInducible nitric oxide synthaseNitric oxideRenal allograft rejectionRenal transplant rejectionNitric oxide synthase inductionInducible NOS (iNOS) mRNAUrine of patientsRenal transplantationTransplantation patientsAllograft rejectionTransplant rejectionInducible NOSOxide synthaseNOS mRNAPatientsSynthase inductionUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMP
1994
Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation
Dokita S, Smith S, Nishimoto T, Wheeler M, Weiss R. Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation. European Journal Of Pharmacology 1994, 266: 269-275. PMID: 7513645, DOI: 10.1016/0922-4106(94)90136-8.Peer-Reviewed Original ResearchConceptsNitric oxide synthase activityTransmural nerve stimulationOxide synthase activityRabbit urethraNerve stimulationNOS activityL-arginineSoluble nitric oxide synthaseNitric oxide synthase inhibitorRelaxation responseNitric oxideCyclic GMPOxide synthase inhibitorNitric oxide synthaseCyclic GMP levelsUrethral relaxationNG-nitroRank orderOxide synthaseSynthase activityNG-methylSynthase inhibitorElectrical stimulationUrethraSame rank order
1988
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments.
Weiss R, Wheeler M. Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments. Journal Of Pharmacology And Experimental Therapeutics 1988, 247: 630-4. PMID: 2846825.Peer-Reviewed Original Research
1981
Resistance of a separated form of canine ureteral phosphodiesterase activity to inhibition by xanthines and papaverine
Weiss R, Hardman J, Wells J. Resistance of a separated form of canine ureteral phosphodiesterase activity to inhibition by xanthines and papaverine. Biochemical Pharmacology 1981, 30: 2371-2374. PMID: 6271142, DOI: 10.1016/0006-2952(81)90117-9.Peer-Reviewed Original Research