2021
Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer
Liu Q, Liu G, Martin DT, Xing YT, Weiss RM, Qi J, Kang J. Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer. Asian Journal Of Andrology 2021, 23: 472-478. PMID: 33762478, PMCID: PMC8451484, DOI: 10.4103/aja.aja_20_21.Peer-Reviewed Original ResearchConceptsDNA methylationRisk lociGene expressionGenome-wide association analysisExpression quantitative trait loci (eQTL) analysisQuantitative trait locus (QTL) analysisMethylation-regulated genesEpigenetic association studiesSingle nucleotide polymorphism analysisNucleotide polymorphism analysisTranscript regulationGenomic regionsCancer Genome AtlasEpigenetic changesEpigenetic alterationsLocus analysisAssociation studiesAssociation analysisProgression of tumorsCpG sitesGenesLociMethylationGenome AtlasImportant locusDown-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis
He S, Li G, Schätzlein AG, Humphrey PA, Weiss RM, Uchegbu IF, Martin DT. Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis. Cellular Signalling 2021, 81: 109931. PMID: 33529758, DOI: 10.1016/j.cellsig.2021.109931.Peer-Reviewed Original ResearchConceptsBladder cancer cellsCancer cellsHuman bladder cancer specimensCisplatin-based chemotherapyBladder cancer treatmentBladder cancer specimensChemoresistant bladder cancer cellsBreast cancer cellsCell viabilityBladder cancerCancer specimensSmall molecule inhibitorsLevels of Ku70Cancer treatmentKu70 expression
2019
Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth
Li X, He S, Tian Y, Weiss RM, Martin DT. Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth. Cellular Signalling 2019, 63: 109381. PMID: 31374291, DOI: 10.1016/j.cellsig.2019.109381.Peer-Reviewed Original ResearchMeSH KeywordsButadienesCarcinoma, Transitional CellCell Line, TumorCell MovementCell SurvivalDrug Resistance, NeoplasmDrug SynergismEnzyme InhibitorsGene Expression Regulation, NeoplasticGlycoproteinsHumansHydrazinesMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1NitrilesQuinoxalinesUrinary Bladder NeoplasmsConceptsChemoresistant bladder cancerBladder cancer cellsBladder cancerInterleukin-6Clinical outcomesMultidrug resistanceGemcitabine-resistant bladder cancer cellsBladder cancer cell growthMajor treatment obstacleMetastatic bladder cancerPI3K/Akt/mTOR signalingCancer cellsResistant bladder cancer cellsPoor clinical outcomeAkt/mTOR SignalingSynergistic inhibitionNovel therapeutic strategiesPotential therapeutic targetMEK/ERK signalingCancer cell growthRaf/MEK/ERK signalingRole of gp130Therapeutic strategiesTreatment obstaclesTherapeutic targetGlycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target
Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM. Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target. Molecular Cancer Therapeutics 2019, 18: molcanther.1079.2017. PMID: 30381445, PMCID: PMC6363894, DOI: 10.1158/1535-7163.mct-17-1079.Peer-Reviewed Original ResearchConceptsBladder cancer cell linesBladder tumorsBladder cancerCancer cell linesHigh-grade bladder cancer cell linesCancer xenograft mouse modelBladder cancer growthAggressive bladder cancerPotential therapeutic targetHuman bladder tumorsXenograft mouse modelBladder cancer progressionCell linesBladder tumor cellsCurative potentialOptimal treatmentTumor gradePatient outcomesReduced cell migrationTumor volumeTumor categoryMouse modelTherapeutic targetTumor aggressivenessCancer growth
2014
Surface-Modified Nanoparticles Enhance Transurothelial Penetration and Delivery of Survivin siRNA in Treating Bladder Cancer
Martin DT, Steinbach JM, Liu J, Shimizu S, Kaimakliotis HZ, Wheeler MA, Hittelman AB, Saltzman W, Weiss RM. Surface-Modified Nanoparticles Enhance Transurothelial Penetration and Delivery of Survivin siRNA in Treating Bladder Cancer. Molecular Cancer Therapeutics 2014, 13: 71-81. PMID: 24222663, PMCID: PMC3924597, DOI: 10.1158/1535-7163.mct-13-0502.Peer-Reviewed Original ResearchConceptsBladder permeability barrierSurvivin siRNAChitosan delivery systemBladder cancerBladder diseaseTherapeutic responseTumor volumeXenograft tumorsMouse bladderTumor siteSurvivin expressionIntravesical deliveryHuman ureterTumor cell uptakeSiRNATumorsUnmodified nanoparticlesCell uptakeDelivery system
2013
Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer
Martin DT, Hoimes CJ, Kaimakliotis HZ, Cheng CJ, Zhang K, Liu J, Wheeler MA, Kelly WK, Tew GN, Saltzman WM, Weiss RM. Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. Nanomedicine Nanotechnology Biology And Medicine 2013, 9: 1124-1134. PMID: 23764660, PMCID: PMC3815967, DOI: 10.1016/j.nano.2013.05.017.Peer-Reviewed Original ResearchConceptsHistone deacetylase inhibitor belinostatBladder cancerBladder permeability barrierNon-invasive bladder cancerCultured bladder cancer cellsBladder cancer cellsChemotherapy efficacyIntravesical drug deliveryXenograft tumorsMouse bladderMouse modelConvincing dataHuman ureterBelinostatCancerCancer cellsLower IC50TumorsAcetyl-H4Tissue penetrationCLINICAL EDITORIntracellular uptakeDeliveryCellsPatients
2008
Prostate expression of endothelins and their receptors in rat growth
Wada Y, Takahashi W, Latifpour J, Weiss RM, Matsumoto K, Matsui K, Yamada, Imamura T. Prostate expression of endothelins and their receptors in rat growth. Reproduction Fertility And Development 2008, 20: 750-759. PMID: 18842177, DOI: 10.1071/rd08052.Peer-Reviewed Original ResearchConceptsET-1Receptors ETAProstate growthProstate lobesET-3Role of ETAVentral prostate lobeReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMultiplex reverse transcription-polymerase chain reactionMRNA expression levelsProstate expressionEndothelinMitogenic effectProstate cellsMRNA expressionMembrane particulatesHigh expressionMonthsWeeksEnzyme 1Chain reactionExpression levelsRat growthRatsInitial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele
Reiner E, Pollak JS, Henderson KJ, Weiss RM, White RI. Initial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele. Journal Of Vascular And Interventional Radiology 2008, 19: 207-210. PMID: 18341950, DOI: 10.1016/j.jvir.2007.08.013.Peer-Reviewed Original ResearchConceptsInternal spermatic veinSodium tetradecyl sulfate foamSTS foamAdolescent patientsPampiniform plexusSI jointLeft internal spermatic veinRight femoral veinResults of treatmentSurgical recurrenceScrotal discomfortTesticular atrophyCollateral vesselsPhysical examinationFemoral veinSpermatic veinSacroiliac jointAdolescent varicoceleFibered coilsPatientsInitial experienceVaricoceleAdolescent subjectsDeliberate passagePlexus
2006
Pacemaker activity in the upper urinary tract
Weiss RM, Tamarkin FJ, Wheeler MA. Pacemaker activity in the upper urinary tract. Journal Of Smooth Muscle Research 2006, 42: 103. PMID: 17099294, DOI: 10.1540/jsmr.42.103.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsTypical smooth muscle cellsMuscle cellsUreteral peristalsisCapsaicin-sensitive sensory afferentsAlpha-smooth muscle actinNormal ureteral peristalsisUpper urinary tractUreteral peristaltic activityUrinary collecting systemTyrosine kinase receptorsSensory afferentsUrinary tractEndogenous releasePeristaltic activityPacemaker activityMuscle actinAction potentialsPacemaker siteC-kitPacemaker cellsProximal portionCollecting systemSparse immunoreactivityElectrical activity
2005
CLINICAL AND HISTOLOGICAL SIGNIFICANCE OF THE TESTICULAR REMNANT FOUND ON INGUINAL EXPLORATION AFTER DIAGNOSTIC LAPAROSCOPY IN THE ABSENCE OF A PATENT PROCESSUS VAGINALIS
RENZULLI JF, SHETTY R, MANGRAY S, ANDERSON KR, WEISS RM, CALDAMONE AA. CLINICAL AND HISTOLOGICAL SIGNIFICANCE OF THE TESTICULAR REMNANT FOUND ON INGUINAL EXPLORATION AFTER DIAGNOSTIC LAPAROSCOPY IN THE ABSENCE OF A PATENT PROCESSUS VAGINALIS. Journal Of Urology 2005, 174: 1584-1586. PMID: 16148657, DOI: 10.1097/01.ju.0000179541.92934.17.Peer-Reviewed Original ResearchConceptsGerm cell elementsPatent processus vaginalisInternal inguinal ringProcessus vaginalisClosed processus vaginalisInguinal explorationTesticular remnantsNonpalpable testisHistological findingsInguinal ringSpermatic vesselsClosed internal inguinal ringVas deferensClosed internal ringPresence of hemosiderinCell elementsDiagnostic laparoscopyLaparoscopic explorationRetrospective reviewHistological significancePatientsLeft sideCord structuresRight sideIncidenceA Survivin Gene Signature Predicts Aggressive Tumor Behavior
Salz W, Eisenberg D, Plescia J, Garlick DS, Weiss RM, Wu XR, Sun TT, Altieri DC. A Survivin Gene Signature Predicts Aggressive Tumor Behavior. Cancer Research 2005, 65: 3531-3534. PMID: 15867343, DOI: 10.1158/0008-5472.can-04-4284.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButylhydroxybutylnitrosamineCarcinogensDisease ProgressionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansInhibitor of Apoptosis ProteinsMembrane ProteinsMiceMice, TransgenicMicrotubule-Associated ProteinsNeoplasm ProteinsPolymerase Chain ReactionSurvivinTransgenesTumor Suppressor Protein p53Urinary BladderUrinary Bladder NeoplasmsUroplakin IIConceptsTransgenic expressionGene signatureGlobal transcriptional changesDominant negative mutantGene expression profilesSuch genesTumor progressionTranscriptional changesCell divisionEssential regulatorGene expressionExpression profilesTransgenic animalsExtracellular matrixTissue microenvironmentAggressive tumor behaviorPreferential incidenceGenesInflammatory genesSurvivinExpressionTumor behaviorSurvivin expressionAssociated gene signaturesTransgenic modelRegulation of cyclic nucleotides in the urinary tract
Wheeler MA, Ayyagari RR, Wheeler GL, Weiss RM. Regulation of cyclic nucleotides in the urinary tract. Journal Of Smooth Muscle Research 2005, 41: 1. PMID: 15855736, DOI: 10.1540/jsmr.41.1.Peer-Reviewed Original ResearchConceptsUrinary tractRelaxation responseLow compliance bladderSmooth muscle functionG proteinsCyclic AMP productionStimulatory G proteinCyclic nucleotide levelsG protein isoformsUrge incontinenceTreatment optionsProstate cancerMuscle functionDisease processFamily of phosphodiesterasesSpecific PDE inhibitorsAMP productionPDE inhibitorsBladderAdenylyl cyclasePDE isoformsTractPharmacological potentialCancerPDE expression
2003
Urinary interleukin-8 levels are elevated in subjects with transitional cell carcinoma
Sheryka E, Wheeler MA, Hausladen DA, Weiss RM. Urinary interleukin-8 levels are elevated in subjects with transitional cell carcinoma. Urology 2003, 62: 162-166. PMID: 12837459, DOI: 10.1016/s0090-4295(03)00134-1.Peer-Reviewed Original ResearchConceptsUrinary IL-8 levelsIL-8 levelsTransitional cell carcinomaBacille Calmette-GuérinIL-8Cell carcinomaCalmette-GuérinProstate cancerHealthy subjectsActive transitional cell carcinomaUrinary interleukin-8 levelsLow stage transitional cell carcinomaInterleukin-8 levelsBladder cancer cell linesBladder cancer cellsEnzyme-linked immunosorbentCancer cell linesIntravesical therapyInflammatory processInvasive tumorsAngiogenic factorsMitomycin CElevated levelsCancer cellsMitomycin C.Effect of Intravesical Treatment of Transitional Cell Carcinoma With Bacillus Calmette-Guerin and Mitomycin C on Urinary Survivin Levels and Outcome
HAUSLADEN DA, WHEELER MA, ALTIERI DC, COLBERG JW, WEISS RM. Effect of Intravesical Treatment of Transitional Cell Carcinoma With Bacillus Calmette-Guerin and Mitomycin C on Urinary Survivin Levels and Outcome. Journal Of Urology 2003, 170: 230-234. PMID: 12796695, DOI: 10.1097/01.ju.0000063685.29339.24.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, IntravesicalAgedAged, 80 and overAntibiotics, AntineoplasticAntigens, NeoplasmBCG VaccineBiomarkers, TumorCarcinoma, Transitional CellFemaleHumansImmunoblottingInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedMitomycinNeoplasm ProteinsNeoplasm Recurrence, LocalPredictive Value of TestsPrognosisSurvivinTreatment OutcomeUrinary Bladder NeoplasmsConceptsTransitional cell carcinomaCompletion of treatmentBacillus Calmette-GuerinUrinary survivin levelsSurvivin levelsTCC recurrenceCalmette-GuerinUrine survivinIntravesical treatmentIntravesical instillationCell carcinomaMitomycin CRecurrent transitional cell carcinomaPrognostic molecular markersHigher survivin levelsUrinary survivinPosttreatment valuesRecurrenceMonthsHigher likelihoodSurvivinRemissionUrineTreatmentInstillation
2002
Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer
Wheeler MA, Hausladen DA, Yoon JH, Weiss RM. Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer. Journal Of Urology 2002, 168: 1568-1573. PMID: 12352459, DOI: 10.1016/s0022-5347(05)64522-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBCG VaccineCyclooxygenase 1Cyclooxygenase 2DinoprostoneEnzyme InductionFemaleGene Expression Regulation, EnzymologicHumansIsoenzymesMaleMembrane ProteinsMiddle AgedProstaglandin-Endoperoxide SynthasesRNA, MessengerUreterUrinary BladderUrinary Bladder NeoplasmsUrinary Tract InfectionsUrogenital NeoplasmsUrotheliumConceptsUrinary prostaglandin E2 levelsUrinary tract infectionProstaglandin E2 levelsUrinary prostaglandin E2Tract infectionsBladder cancerProstaglandin E2 productionBCG treatmentCOX-2 mRNAUrogenital cancersE2 levelsUrine particulatesBladder muscleInflammatory processProstaglandin E2E2 productionBacillus Calmette-Guerin treatmentCOX-2 protein levelsCOX-2 protein expressionHuman urinary tract infectionsUrinary prostaglandin levelsCOX-2 expressionHuman bladder muscleBladder cancer casesCyclooxygenase-2 inductionBladder cancer detection with urinary survivin, an inhibitor of apoptosis.
Sharp JD, Hausladen DA, Maher MG, Wheeler MA, Altieri DC, Weiss RM. Bladder cancer detection with urinary survivin, an inhibitor of apoptosis. Frontiers In Bioscience-Landmark 2002, 7: e36-41. PMID: 11815300, DOI: 10.2741/sharp.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBiomarkersCarcinoma, Transitional CellChromosomal Proteins, Non-HistoneCystoscopyCytodiagnosisHumansImmunoblottingInhibitor of Apoptosis ProteinsMicrotubule-Associated ProteinsNeoplasm ProteinsNeoplasm Recurrence, LocalSensitivity and SpecificitySurvivinUrinary Bladder NeoplasmsPrognostic value of urodynamic testing in myelodysplastic patients
McGuire EJ, Woodside JR, Borden TA, Weiss RM. Prognostic value of urodynamic testing in myelodysplastic patients. Journal Of Urology 2002, 167: 1049-1053. PMID: 11905876, DOI: 10.1016/s0022-5347(02)80338-x.Peer-Reviewed Original ResearchConceptsUrethral closure pressureMyelodysplastic patientsIntravesical pressureIntermittent catheterizationUrinary controlDetrusor responseUreteral dilatationVesicoureteral refluxExcretory urographyUrethral leakageVesical outletExternal urethral sphincter electromyographyHigh urethral closure pressureUpper urinary tract deteriorationClosure pressureGood urinary controlReflex detrusor activityUrethral sphincter electromyographyUrinary tract deteriorationCent of patientsFluoroscopic voiding cystourethrographyLow-pressure groupUrethral pressure profilometryAnticholinergic therapyCoordinated micturition
2001
Urine Detection of Survivin and Diagnosis of Bladder Cancer
Smith SD, Wheeler MA, Plescia J, Colberg JW, Weiss RM, Altieri DC. Urine Detection of Survivin and Diagnosis of Bladder Cancer. JAMA 2001, 285: 324-328. PMID: 11176843, DOI: 10.1001/jama.285.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorBlotting, WesternFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalPrognosisProteinsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityStatistics, NonparametricSurvivinUrinary Bladder NeoplasmsUrogenital NeoplasmsUrologic DiseasesConceptsRecurrent bladder cancerUrinary tract diseaseBladder cancerUrine samplesTract diseaseHealthy volunteersSurvivin levelsProstate-specific antigen levelLow-grade bladder cancerPrognostic molecular markersNoninvasive diagnostic testTranscriptase-polymerase chain reactionCommon human cancersUrine survivinGenitourinary cancersProgression of cancerAggressive diseaseAntigen levelsCervical cancerUrology clinicPolymerase chain reactionUnfavorable outcomeCystoscopy resultsRT-PCR methodSurvivin detection
2000
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients
Smith S, Wheeler M, Lorber M, Weiss R. Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients. Kidney International 2000, 58: 829-837. PMID: 10916108, DOI: 10.1046/j.1523-1755.2000.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultCreatinineCyclic GMPCytokinesFemaleFollow-Up StudiesGraft RejectionHumansInterleukin-10Interleukin-2Interleukin-6Interleukin-8Kidney Failure, ChronicKidney TransplantationMaleMiddle AgedNitratesNitric OxideNitritesPredictive Value of TestsTime FactorsTumor Necrosis Factor-alphaUrinary Tract InfectionsConceptsUrinary tract infectionRenal transplant patientsAcute rejectionTransplant patientsCyclic GMPIL-2Nitric oxideNitric oxide synthase activityAdditional urine specimensUrine cytokine levelsUrine nitrate levelsNitric oxide productsMonths of transplantationOxide synthase activityUrine nitrateSoluble interleukinCytokine levelsTract infectionsIL-10IL-6IL-8Tumor necrosisUrine specimensPatientsClinical diagnosis
1999
Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer
Swana H, Grossman D, Anthony J, Weiss R, Altieri D. Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer. New England Journal Of Medicine 1999, 341: 452-453. PMID: 10438269, DOI: 10.1056/nejm199908053410614.Peer-Reviewed Original ResearchAgedApoptosisBiomarkers, TumorCarcinoma, Transitional CellDisease ProgressionFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalProteinsProto-Oncogene Proteins c-bcl-2SurvivinTumor Suppressor Protein p53Urinary Bladder Neoplasms