1997
Muscarinic Receptor Subtypes and Receptor‐Coupled Phosphatidylinositol Hydrolysis in Rat Bladder Smooth Muscle
Mimata H, Nomura Y, Emoto A, Latifpour J, Wheeler M, Weiss R. Muscarinic Receptor Subtypes and Receptor‐Coupled Phosphatidylinositol Hydrolysis in Rat Bladder Smooth Muscle. International Journal Of Urology 1997, 4: 591-596. PMID: 9477190, DOI: 10.1111/j.1442-2042.1997.tb00315.x.Peer-Reviewed Original ResearchConceptsRat bladder smooth muscleBladder smooth muscleMuscarinic receptor subtypesSmooth muscleM3 receptorsReceptor subtypesPI hydrolysisCarbachol stimulationBladder smooth muscle contractionPhosphatidylinositol hydrolysisN-methylpiperidine methiodideRat urinary bladderSubtype-specific antagonistsSmooth muscle contractionProduction of IP3Expression of mRNAContractile responseUrinary bladderSpecific antagonistMuscle contractionBasal levelsInhibitory effectSubtypesReceptorsMuscle
1995
Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder
Mimata H, Wheeler M, Fukumoto Y, Takigawa H, Nishimoto T, Weiss R, Latifpour J. Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder. Molecular And Cellular Biochemistry 1995, 152: 71-76. PMID: 8609914, DOI: 10.1007/bf01076465.Peer-Reviewed Original ResearchConceptsDiabetic bladderRat bladderAltered functional responseControl rat bladdersCarbachol-induced increaseMuscarinic receptor densityPhosphatidyl inositol hydrolysisMuscarinic agonist stimulationSucrose-fed animalsRat detrusorContractile responseInositol phosphate productionMuscarinic receptorsMuscarinic agonistsReceptor densityBladderAgonist stimulationPhosphatidylinositol metabolismInositol uptakeEC50 valuesSignal transduction pathwaysPhosphate productionTransduction pathwaysDetrusorStreptozotocinEffect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract
Wheeler M, Martin T, Weiss R. Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract. Journal Of Urology 1995, 153: 2044-2049. PMID: 7752391, DOI: 10.1016/s0022-5347(01)67399-3.Peer-Reviewed Original ResearchConceptsPhosphatidyl inositol hydrolysisPI hydrolysisCyclic AMP levelsCAMP levelsBladder domeAMP levelsUrinary tract functionEffect of carbacholGuinea-pig ureterAgonist-induced changesBasal cAMP levelsUrinary tractMuscarinic cholinergicTract functionSecond messenger systemsCarbacholNorepinephrinePig ureterSustained increaseUreterUrethraSecond messenger levelsMessenger systemsForskolinTransitory increase
1981
Resistance of a separated form of canine ureteral phosphodiesterase activity to inhibition by xanthines and papaverine
Weiss R, Hardman J, Wells J. Resistance of a separated form of canine ureteral phosphodiesterase activity to inhibition by xanthines and papaverine. Biochemical Pharmacology 1981, 30: 2371-2374. PMID: 6271142, DOI: 10.1016/0006-2952(81)90117-9.Peer-Reviewed Original Research